今日文獻聚焦於etomidate類似物(特別是4F-metomidate)在電子菸中的檢測與代謝轉換,顯示其經肝臟代謝產生具活性的metomidate,此現象 complicates forensic interpretation 並凸顯監測新興psychoactive substances在電子煙品中的必要性,對公共衛生與政策提出早期預警需求。
Legal medicine (Tokyo, Japan) · Detection and quantification of 4F-metomidate and its metabolites, metomidate, in human blood and urine by ultraperformance liquid chromatography with triple quadrupole mass spectrometry (UPLC-MS/MS)
首次建立靈敏且特異的UPLC-MS/MS方法同時定量4F-metomidate與metomidate於生物樣本,並證實其在人體肝微粒中可代謝轉換,提醒metomidate的檢出不一定代表直接攝取,可能來自類似物代謝,具有重要法醫與臨床解釋意義。
Drug testing and analysis · Etomidate Analogues in E-Cigarettes: Linking Structural Characterization to Regional Early Warning.
透過結構鑑定等omidate類似物於電子菸中,建議將其納入區域早期警示系統,以加速公共衛生對新興吸入式致醫性物質的偵測與回應。