今日文獻聚焦於 etomidate-laced 電子煙之隱匿風險,首次揭示 4F-metomidate 在生體內代謝為 metomidate,凸显常規毒篩無法偵測力與麻醉科術前評估之緊急需求,具重要公共衛生與臨床政策啟示。
Legal medicine (Tokyo, Japan) · Detection and quantification of 4F-metomidate and its metabolites, metomidate, in human blood and urine by ultraperformance liquid chromatography with triple quadrupole mass spectrometry (UPLC-MS/MS).
開發出首個可同時偵測 4F-metomidate 及其代謝物 metomidate 的超高效液相層析串聯質譜法,證實電煙液中僅偵測到前體物,但生體樣本含代謝物,提醒藥檢須考慮代謝轉換以避免誤判。
Canadian journal of anaesthesia = Journal canadien d'anesthesie · Drug-laced vaping-implications and emerging perioperative challenges for the anesthesiologist: a narrative review.
揭露 etomidate-laced 電子煙可能導致術中腎上腺抑制、呼吸抑制與心血管不穩,且常見毒篩無法偵測,凸显麻醉科術前詳細史詢與症候群評估之必要性。