2026年9月19日（星期六）
本日收錄 40 篇文獻The impact of TcdB conformational dynamics on vaccination against Clostridioides difficile.
Clostridioides difficile TcdB is a multidomain ~270 kDa protein that adopts at least two distinct structural conformations influencing receptor binding, sensitivity to bile salts, and antibody reactiv
Reduction in T-Cell Mitochondrial Respiratory Capacity After Reaching a Weight Loss Plateau.
UNLABELLED: Experiencing an involuntary weight loss plateau is common after behavioral weight loss. During such periods, sustained negative energy balance activates counterregulatory mechanisms that r
Unimolecular GLP-1/APJ receptor co-agonism improves metabolism and dyslipidaemia as well as normalising hepatic triglyceride and aminotransferase elevation in high-fat-fed mice.
AIMS/HYPOTHESIS: The aim of this study was to determine the applicability of dual activation of glucagon-like peptide-1 (GLP-1) and apelin (APJ) receptors as a next-generation therapeutic option for o
Adolescent Obesity: A Stepwise Clinical Approach.
Adolescent obesity is one of the most pressing pediatric public health challenges of this generation, with a near tripling of prevalence over three decades. Most adolescents with obesity have an exoge
When Ultra-Processed Foods are Eaten: The Missing Dimension in Exposure Measurement for Obesity Research.
PURPOSE OF REVIEW: Almost every study linking ultra-processed foods (UPFs) to obesity measures exposure as the proportion of energy or weight derived from Nova group 4 foods, averaged across days. Thi
The impact of TcdB conformational dynamics on vaccination against Clostridioides difficile.
Clostridioides difficile TcdB is a multidomain ~270 kDa protein that adopts at least two distinct st
Reduction in T-Cell Mitochondrial Respiratory Capacity After Reaching a Weight Loss Plateau.
UNLABELLED: Experiencing an involuntary weight loss plateau is common after behavioral weight loss.
Unimolecular GLP-1/APJ receptor co-agonism improves metabolism and dyslipidaemia as well as normalising hepatic triglyceride and aminotransferase elevation in high-fat-fed mice.
AIMS/HYPOTHESIS: The aim of this study was to determine the applicability of dual activation of gluc
Adolescent Obesity: A Stepwise Clinical Approach.
Adolescent obesity is one of the most pressing pediatric public health challenges of this generation
When Ultra-Processed Foods are Eaten: The Missing Dimension in Exposure Measurement for Obesity Research.
PURPOSE OF REVIEW: Almost every study linking ultra-processed foods (UPFs) to obesity measures expos
Normal weight obesity: a South Asian phenotype.
PURPOSE OF REVIEW: Recent guidelines emphasize the significance of measuring adiposity rather than r
Collagen I promotes cancer cell survival via amino acid import and mTORC1/S6 activation.
Invasive breast and pancreatic cancer cells thrive within a collagen I-rich, poorly perfused extrace
From colonisation to immune evasion: a synthesis of the interaction strategies that drive Staphylococcus aureus infection.
Staphylococcus aureus (S. aureus) remains a major human and veterinary pathogen, driven by multiple
Targeting the cardiohepatic-metabolic axis: GLP-1-based and incretin multi-agonist therapies in MASH.
Metabolic dysfunction-associated steatohepatitis (MASH) has emerged as a leading cause of chronic li
Real-World Adherence Trajectories of GLP-1 Receptor Agonists Among Adults and Paediatric Patients With Obesity.
AIMS: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly used for obesity treatm
Preferences for Obesity Medications Among People With Overweight or Obesity in the United States: A Discrete-Choice Experiment (OPTIC).
AIMS: To evaluate the relative importance of attributes driving obesity medication (OM) choice and p
Efficacy and Safety of a Novel Reversible Gastric Bypass Stent System for Weight Loss: A Multicentre Real-World Study.
OBJECTIVE: To evaluate the clinical efficacy and safety of the Gastric Bypass Stent System (GBSS), a
Effectiveness, Safety and Pharmacokinetics of BGM0504, a Dual GLP-1/GIP Receptor Agonist, in Chinese Adults With Overweight or Obesity Without Diabetes: A Phase 2 Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial.
AIMS: To evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and efficacy of
Sustainable preservation of shell eggs using ultrasound and electrolyzed water: individual and synergistic effects.
BACKGROUND: Maintaining the internal quality and functional properties of shell eggs during storage
A nationwide multicenter observational study on childhood scurvy in Japan.
OBJECTIVES: Although scurvy is rare in developed countries, cases in children with selective diets d
Neighborhoods matter: contextual determinants of bariatric surgery utilization and weight loss in Washington, D.C.
INTRODUCTION: Bariatric surgery is the most effective durable treatment for severe obesity, yet neig
Validation and refinement of a biomarker panel for frailty assessment and prediction of muscle weakness in older adults.
Frailty is a complex geriatric syndrome characterized by age-related declines in physiological funct
Do Preoperative Glucagon-Like Peptide-1 Receptor Agonists Influence Lumbar Fusion Outcomes? A Systematic Review and Meta-Analysis.
BACKGROUND: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly used in patients w
Semaglutide as adjunct treatment for obesity in adolescents receiving antipsychotic medication (the GOAL trial): protocol for a single-arm, open-label feasibility study.
INTRODUCTION: Adolescents treated with antipsychotic medication are at increased risk of obesity and
Liver Fibrosis and IRS1 rs2972146 Are Associated With Weight Loss Response After Metabolic Bariatric Surgery.
BACKGROUND AND AIMS: Weight loss after metabolic bariatric surgery (MBS) is heterogeneous, and the c
Nutrigenomics in the prevention and management of type 2 diabetes and obesity: A systematic review of clinical trials.
BackgroundThe increasing global burden of obesity and type 2 diabetes mellitus (T2DM) poses a major
Effect of GLP-1 receptor agonist on nutrient intake: A narrative review.
Humans have a primitive defense mechanism called metabolic adaptation that slows voluntary weight lo
Protective role of wheat bran in high-fat diet-induced metabolic dysfunction in Wistar rats.
BackgroundA high-fat diet (HFD) is associated with excessive energy intake that leads to weight gain
Associations of parental, pregnancy and infant characteristics with appetite traits in infancy: Results from a prospective study of infants in Cyprus.
Parental and infant factors (eg pre-pregnancy maternal BMI, gestational body weight, breast or formu
[Sarcopenia in gastrointestinal oncology: Diagnostic criteria, clinical implications and management].
Sarcopenia is defined as a loss of muscle mass and strength. It represents a frequent and multifacto
Bidirectional longitudinal associations between adiposity and emotional and uncontrolled eating in an observational UK population-based cohort.
BACKGROUND: Eating behaviour traits (EBTs), including uncontrolled eating (UE) and emotional eating
Barriers and Facilitators of Implementing an Online Weight Loss Program and App with Patients: A Qualitative Study of Registered Dietitian Nutritionists' Perspectives.
BACKGROUND: Registered dietitian nutritionists (RDNs) play a pivotal role in providing dietary educa
EEG neurofeedback for children with overweight and obesity: A proof-of-concept study.
OBJECTIVE: Current treatment options for childhood overweight and obesity do not sufficiently addres
Exit Interviews Examining Patient Experiences with Tirzepatide and Dulaglutide for Treatment of Type 2 Diabetes in the SURPASS-CVOT Trial.
INTRODUCTION: Qualitative exit interviews with people who recently completed a clinical trial can pr
The Incretin Mirage: Epigenetic Memory as a Potential Driver of Post-Treatment Weight Regain.
While incretin receptor agonists deliver profound weight loss, clinical data reveal a consistent cha
Metabolic reprogramming in T-cell acute lymphoblastic leukemia: Mechanisms of therapy resistance and clinical applications.
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy in which therapy
Pharmacological intersections between type 2 diabetes and cancer: metabolic crosstalk, antidiabetic therapies, and clinical implications.
Type 2 diabetes (T2D) and cancer frequently coexist and are connected by hyperinsulinemia, hyperglyc
Machine learning identifies microbiome and clinical predictors of sustained weight loss following prolonged fasting.
BACKGROUND: Prolonged fasting may improve metabolic health, but controlled data in healthy adults wi
Atherogenic lipid profile changes and their cardiovascular consequences across degrees of obesity in children and adolescents: a structured narrative review.
Childhood and adolescent obesity is strongly associated with an atherogenic lipid profile and silent
Mechanism and clinical relevance of metabolic-immune cross-talk in pancreatic tumor microenvironment.
Metabolic stress-induced immunosuppression begins as early as the precancerous stage in pancreatic d
ENCOURAGEing Start: A Quasi-Experimental Trial on Pre-Op Physical Activity Intervention for Bariatric Surgery Candidates.
INTRODUCTION: The American Society for Metabolic and Bariatric Surgery recommends pre- and post-oper
Simultaneous and recurrent hordeola and chalazia associated with tirzepatide therapy: a case series.
Glucagon-like peptide-1 (GLP-1) and dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) re
Family Dynamics and Longitudinal Trends in Pediatric Obesity: A Real-World Observational Study in a Public Outpatient Clinic.
BACKGROUND: Childhood obesity remains a major public health challenge, and evidence on the outcomes
Neuroschistosomiasis Mimicking Spinal Tuberculosis: A Case Report.
Schistosomiasis is a chronic parasitic disease acquired through freshwater exposure, in which cercar
The clinical relevance of obesity and glucagon-like peptide-1-based therapies for chronic weight management in patients treated by obstetrician-gynecologists and gynecologists: A non-systematic narrative review.
Women pre- or post-menopause and living with obesity are at an increased risk of obesity-related com