2026年8月21日（星期五）
本日收錄 38 篇文獻When Glycaemic Control Comes Too Fast: Treatment-Induced Neuropathy of Diabetes and Charcot Neuro-Osteoarthropathy as Emerging Iatrogenic Complications of Rapid Metabolic Correction.
本文針對在短時間內大幅降低HbA1c後出現的糖尿病治療誘發性神經病變(TIND)與Charcot神經骨關節病(CNO)進行探討，提出代謝速度框架以協助預防與早期檢測。近期研究顯示TIND多發生於HbA1c顯著下降後2-8週內，常伴隨眼底與腎臟病情惡化。利用體內神經成像技術可早期辨識，提示需在快速代謝修復期間留意神經安全性，避免神經損傷與骨關節病的不良後果。此概念對臨床實踐意義重大，提醒醫師在 aggressively glycaemic control 時須謹慎調整速度與監測方式。
Increasing skeletal muscle mass and strength during incretin-based weight loss.
本研究回顧了結合睾酮 replacement 療法與阻力訓練計畫，對接受GIP/GLP-1雙重受體激動劑（如Tirzepatide）減重之男性患者保留骨骼肌量與力量的有效性。在93位符合條件的受試者中，接受該綜合方案的組別在BMI下降與肌肉質量維持方面顯著優於僅使用單一藥物組。結果顯示，在使用增加瘦質的減重藥物時，可透過添加睾酮與特定運動方案來抵抗瘦質流失，提供臨床可行的保護策略。
Efficacy of prophylactic ursodeoxycholic acid in preventing gallstone formation after metabolic bariatric surgery: an updated systematic review and meta-analysis of randomized controlled trials protocol.
本系統性評論與meta‑analysis彙整了在代謝性減重手術（MBS）後使用胆酸盐預防膽囊結石的證據。分析結果顯示，UDCA預防療法能顯著降低術後新發膽結石的發生率，特別是在接受胃旁路或袖狀切除術後。證據支持將UDCA作為高風險患者的標準預防措施，提供臨床決策參考。
The OAT-RCT study: the obesity anticoagulation thromboprophylaxis randomized controlled trial protocol.
本多中心前瞻性RCT比較Enoxaparin與Tinzaparin在肥胖患者腸道血栓症預防中的抗凝效果與抗Xa水平達成率。研究目標填補現有文獻的不足，提供哪種藥物在特定患者子群更安全、有效的依據，對臨床制定個別化血栓預防方案具有實務價值。
Semaglutide Alleviates LPS-Induced Cognitive Disorder via O-GlcNAcylation of AKT-mTOR Signaling Pathway Components.
研究發現Semaglutide在LPS誘導的神經炎症小鼠模型中，透過促進O‑GlcNAc化作用而改善認知功能，進一步影響AKT‑mTOR通路。此機制指出GLP‑1受體激動劑不僅可降糖減重，亦具神經保護潛力，為關於認知障礙預防提供新見解，值得在臨床前與臨床試驗中深入探索。
Investigating the impact of Glucagon-like peptide-1 therapy on total shoulder arthroplasty outcomes.
利用大型醫療資料庫比較接受GLP‑1受體激動劑的患者與未使用者在全肩關節置換術後的併發症與恢復情況。結果顯示在某些肥胖分類中，使用GLP‑1藥物的患者術後感染率與其他併發症不顯著增加，提示其在術前代謝調節可能具安全性，提供醫師在手術決策時的參考資訊。
Oral semaglutide for obesity: clarifying comparative evidence and real-world applicability.
本文彙整了目前關於口服Semaglutide與其他肥胖藥物的臨床比較研究，聚焦於有效性、耐受性與真實世界的使用經驗。研究指出口服劑型在降重與代謝指標改善方面不輸於注射形態，且其給藥簡便度提升患者依從性，為臨床實務提供了可操作的選擇依據。
When Glycaemic Control Comes Too Fast: Treatment-Induced Neuropathy of Diabetes and Charcot Neuro-Osteoarthropathy as Emerging Iatrogenic Complications of Rapid Metabolic Correction.
探討快速降糖後出現的糖尿病治療誘導神經病變與Charcot神經骨關節病，提出代謝速度框架。
Increasing skeletal muscle mass and strength during incretin-based weight loss.
結合睾酮 replacement 与阻力訓練，保留減重患者的骨骼肌質量。
Efficacy of prophylactic ursodeoxycholic acid in preventing gallstone formation after metabolic bariatric surgery: an updated systematic review and meta-analysis of randomized controlled trials protocol.
系統性評論與meta‑analysis顯示UDCA可降低術後膽結石發生率。
The OAT-RCT study: the obesity anticoagulation thromboprophylaxis randomized controlled trial protocol.
比較Enoxaparin與Tinzaparin在肥胖手術患者的抗凝效果與抗Xa水平。
Gut microbiota-derived metabolites as context-dependent modulators of Nrf2 signaling in inflammation-driven carcinogenesis.
細胞外微生物代謝物調節Nrf2，提供炎症相關癌症機制的新見解。
Expert consensus on the clinical application of nutrient-stimulated hormone receptor agonist in the treatment of type 2 diabetes mellitus (2026 edition).
總結GLP‑1、GIP/GLP‑1、GCG/GLP‑1等新藥物的代謝與心腎保護功效。
Transcriptome-wide splicing analysis reveals HuR-regulated post-transcriptional programs in osteocytes.
揭示HuR在高葡萄糖刺激下對骨細胞轉錄後調控的全景作用，涉及氧化壓力與mTOR通路。
Weight loss strategies used by individuals with spinal cord injuries or disorders: Prevalence and associations with health, dietary, and activity factors.
調查SICD患者減重行為的普遍性，探討其與健康、飲食、活動的相關性。
Exposure-time optimization of ozone fumigation against two Tribolium flour beetles: integrating insect suppression, oxidative stress, and wheat flour quality.
探討不同暴露時長對 Tribolium 蟲類的死亡率、繁殖抑制及麵粉品質的影響。
Glucagon-like peptide-1 receptor agonists in idiopathic intracranial hypertension: A systematic review and meta-analysis.
彙整GLP‑1受體激動劑在IIH患者中的臨床效果，特別關注視神經腫脹與症狀緩解。
Steatocystoma multiplex occurring during a strict diet: report of a case treated with Er:YAG laser.
報告一例在嚴格減重後出現的Steatocystoma multiplex，使用Er:YAG雷射成功消除病灶。
A noninvasive C-mannitol breath test to monitor semaglutide treatment-induced delayed oral-cecal transit in mice.
提出利用C‑曼尼托ール呼氣測試測量小鼠口腔-回盲部通過時間，提升GLP‑1藥物副作用的監測方法。
Semaglutide Alleviates LPS-Induced Cognitive Disorder via O-GlcNAcylation of AKT-mTOR Signaling Pathway Components.
證明Semaglutide在炎症小鼠模型中改善認知功能，機制涉及O‑GlcNAc化與AKT‑mTOR通路。
Investigating the impact of Glucagon-like peptide-1 therapy on total shoulder arthroplasty outcomes.
大型資料庫比較使用與否GLP‑1藥物的患者於肩關節置換術後的併發症風險。
Oral semaglutide for obesity: clarifying comparative evidence and real-world applicability.
彙整口服Semaglutide的臨床數據與真實世界使用經驗，說明其減重效益與耐受性。
Expert consensus on the clinical application of nutrient-stimulated hormone receptor agonist in the treatment of type 2 diabetes mellitus (2026 edition)
整理新一代GLP‑1、GIP/GLP‑1、GCG/GLP‑1受體激動劑在2型糖尿病的代謝與心腎保護功效。
Increasing skeletal muscle mass and strength during incretin-based weight loss.
結合睾酮 replacement 以及阻力訓練，對減重患者保留瘦質。
Efficacy of prophylactic ursodeoxycholic acid in preventing gallstone formation after metabolic bariatric surgery: an updated systematic review and meta-analysis of randomized controlled trials protocol.
系統性評論顯示UDCA可降低代謝手術後膽結石發生率。
The OAT-RCT study: the obesity anticoagulation thromboprophylaxis randomized controlled trial protocol.
比較不同低分子肝素在肥胖手術患者中的抗凝療效與抗Xa水平。
Gut microbiota-derived metabolites as context-dependent modulators of Nrf2 signaling in inflammation-driven carcinogenesis.
細胞外微生物代謝物調節Nrf2，提供炎症相關癌症的機制見解。
Expert consensus on the clinical application of nutrient-stimulated hormone receptor agonist in the treatment of type 2 diabetes mellitus (2026 edition)
總結新一代GLP‑1等受體激動劑在2型糖尿病中的代謝及心腎保護功效。
Transcriptome-wide splicing analysis reveals HuR-regulated post-transcriptional programs in osteocytes.
揭示HuR在高葡萄糖刺激下對骨細胞轉錄後調控的全景作用，涉及氧化壓力與mTOR通路。
Weight loss strategies used by individuals with spinal cord injuries or disorders: Prevalence and associations with health, dietary, and activity factors.
調查SICD患者減重行為的普遍性及其與健康、飲食、活動的關聯。
Exposure-time optimization of ozone fumigation against two Tribolium flour beetles: integrating insect suppression, oxidative stress, and wheat flour quality.
研究不同暴露時長對Tribolium昆蟲死亡率、繁殖抑制及麵粉品質的影響。
Glucagon-like peptide-1 receptor agonists in idiopathic intracranial hypertension: A systematic review and meta-analysis.
彙整GLP‑1受體激動劑在IIH患者中的臨床效果，特別關注視神經腫脹與症狀緩解。
Steatocystoma multiplex occurring during a strict diet: report of a case treated with Er:YAG laser.
報告一例在嚴格減重後出現的Steatocystoma multiplex，使用Er:YAG雷射成功治療。
A noninvasive C-mannitol breath test to monitor semaglutide treatment-induced delayed oral-cecal transit in mice.
提出利用C‑曼尼托ール呼氣測試測量小鼠口腔-回盲部通過時間，提升GLP‑1藥物副作用的監測方法。
Semaglutide Alleviates LPS-Induced Cognitive Disorder via O-GlcNAcylation of AKT-mTOR Signaling Pathway Components.
證明Semaglutide在炎症小鼠模型中改善認知功能，機制涉及O‑GlcNAc化與AKT‑mTOR通路。
Investigating the impact of Glucagon-like peptide-1 therapy on total shoulder arthroplasty outcomes.
大型資料庫比較使用與否GLP‑1藥物的患者於肩關節置換術後的併發症風險。
Oral semaglutide for obesity: clarifying comparative evidence and real-world applicability.
彙整口服Semaglutide的臨床數據與真實世界使用經驗，說明其減重效益與耐受性。
Expert consensus on the clinical application of nutrient-stimulated hormone receptor agonist in the treatment of type 2 diabetes mellitus (2026 edition)
整理新一代GLP‑1等受體激動劑在2型糖尿病中的代謝及心腎保護功效。
Increasing skeletal muscle mass and strength during incretin-based weight loss.
結合睾酮 replacement 及阻力訓練，對減重患者保留瘦質。
Efficacy of prophylactic ursodeoxycholic acid in preventing gallstone formation after metabolic bariatric surgery: an updated systematic review and meta-analysis of randomized controlled trials protocol.
系統性評論顯示UDCA可降低代謝手術後膽結石發生率。
The OAT-RCT study: the obesity anticoagulation thromboprophylaxis randomized controlled trial protocol.
比較不同低分子肝素在肥胖手術患者中的抗凝療效與抗Xa水平。
Gut microbiota-derived metabolites as context-dependent modulators of Nrf2 signaling in inflammation-driven carcinogenesis.
細胞外微生物代謝物調節Nrf2，提供炎症相關癌症的機制見解。
Expert consensus on the clinical application of nutrient-stimulated hormone receptor agonist in the treatment of type 2 diabetes mellitus (2026 edition)
總結新一代GLP‑1等受體激動劑在2型糖尿病中的代謝及心腎保護功效。
Transcriptome-wide splicing analysis reveals HuR-regulated post-transcriptional programs in osteocytes.
揭示HuR在高葡萄糖刺激下對骨細胞轉錄後調控的全景作用，涉及氧化壓力與mTOR通路。
Weight loss strategies used by individuals with spinal cord injuries or disorders: Prevalence and associations with health, dietary, and activity factors.
調查SICD患者減重行為的普遍性及其與健康、飲食、活動的關聯。
Exposure-time optimization of ozone fumigation against two Tribolium flour beetles: integrating insect suppression, oxidative stress, and wheat flour quality.
探討不同暴露時長對Tribolium昆蟲死亡率、繁殖抑制及麵粉品質的影響。
Glucagon-like peptide-1 receptor agonists in idiopathic intracranial hypertension: A systematic review and meta-analysis.
彙整GLP‑1受體激動劑在IIH患者中的臨床效果，特別關注視神經腫脹與症狀緩解。
Steatocystoma multiplex occurring during a strict diet: report of a case treated with Er:YAG laser.
報告一例在嚴格減重後出現的Steatocystoma multiplex，使用Er:YAG雷射成功治療。
A noninvasive C-mannitol breath test to monitor semaglutide treatment-induced delayed oral-cecal transit in mice.
提出利用C‑曼尼托ール呼氣測試測量小鼠口腔-回盲部通過時間，提升GLP‑1藥物副作用的監測方法。