2026年7月25日（星期六）
本日收錄 36 篇文獻Comparison of non-insulin glucose-lowering therapies on coronary atherosclerotic plaque progression in diabetes.
本研究利用冠狀動脈電腦斷層血管攝影追蹤880名第二型糖尿病患者，比較五類非胰島素降糖藥物對冠狀動脈斑塊進展的影響。結果顯示GLP-1受體促效劑在延緩冠狀動脈粥狀硬化進展方面表現最優，為GLP-1藥物的心血管保護機制提供直接影像學證據。此發現對於糖尿病合併心血管疾病高風險患者的用藥選擇具有重要臨床指導意義。
AI and Chatbot-Supported Interventions for Physical Activity and Obesity-Related Lifestyle Behaviors: Scoping Review With Attention to Family Involvement.
本範圍性審查探討AI與聊天機器人在兒童青少年體能活動及肥胖相關行為介入的設計與實施，特別關注家長與家庭的參與程度。研究發現AI工具具備提供個人化、可擴展支持潛力，但目前證據仍有限，且家庭參與模式尚未被明確特徵化。此研究為數位健康工具在兒童肥胖防治的應用提供重要發展藍圖。
One receptor, two opposite approaches: efficacy and tolerability of GIPR agonism and antagonism in obesity pharmacotherapy.
GLP-1受體促效劑改寫了肥胖治療，但胃腸道副作用限制劑量遞增。雙重GLP-1/GIP受體促效劑的成功引發對GIP生物學的重新關注，卻揭露一個根本矛盾：GIP受體激動與拮抗兩種相反策略皆顯示減重效果。本文深入探討此悖論，分析Tirzepatide與MariTide等藥物的作用機制，為下一代肥胖藥物開發提供關鍵理論基礎。
Semaglutide for prevention of type 2 diabetes in women with postpartum prediabetes after gestational diabetes: protocol for a Belgian multicentre double-blind randomised placebo-controlled trial.
妊娠糖尿病後產後前期糖尿病女性發展為第二型糖尿病的風險極高，而傳統生活型態介入在此時期成效有限。SERENA試驗旨在評估Semaglutide在早期產後期預防T2DM進展的療效、安全性與成本效益。此研究將為高風險女性族群提供重要的藥物預防策略證據，具備重大公共衛生意義。
Comparison of lifestyle, surgery, and semaglutide for weight management in endometrial cancer: a prospective observational study.
本研究比較袖狀胃切除術、Semaglutide治療與DEAR體重管理計畫在子宮內膜癌保留生育力治療患者中的減重效果。一年追蹤顯示袖狀胃切除術減重幅度最大，三組皆達到體重下降。此研究為癌症患者提供不同減重策略的實證比較，有助臨床團隊與患者進行共享決策，整合腫瘤學與肥胖醫學。
Oral-gut strain sharing after Roux-en-Y gastric bypass: A canonical oral microbiome signature in the gut linked to hepatic and glycemic remodeling.
本研究追蹤25名接受RYGB手術患者術前及術後12個月的口腔與糞便樣本，發現手術促進口腔菌株轉移至遠端腸道並擴增。這些口腔典型菌株與肝臟及血糖代謝改善相關，機器學習模型證實其具預測價值。此發現揭示減重手術後腸道微生物重組的新機制，為理解手術代謝效益開闢新視角。
A survey of primary care physicians' views on supporting patients who lose insurance coverage for Glucagon-Like Peptide-1-based drugs for weight management.
調查美國中西部學術醫療中心基層醫師對患者失去GLP-1藥物保險覆蓋時的準備度，發現醫師對替代療法認知有限，可能影響體重維持。
Bitter hop nutraceutical stimulates fat mass loss while preserving muscle mass in a cohort of individuals with overweight or obesity receiving diet and exercise advice.
隨機雙盲試驗顯示苦味啤酒花補充劑可提升GLP-1與CCK，作為生活型態介入的輔助療法，能有效減脂且保留肌肉質量。
AI and Chatbot-Supported Interventions for Physical Activity and Obesity-Related Lifestyle Behaviors: Scoping Review With Attention to Family Involvement.
探討AI與聊天機器人在兒童肥胖防治的應用現況，發現證據有限且家庭參與模式待明確化，為數位健康工具發展提供藍圖。
[Management of elevated blood pressure and hypertension : Focus on risk reduction].
2024年ESC高血壓指引引入「血壓升高」類別，強調早期預防，建議健康生活型態包括減重、運動、限鹽等作為基礎介入。
Intravenous placenta-derived mesenchymal stem cells enhance early survival as an adjunct to supportive care in severe burn: a preclinical study.
大鼠燒傷模型顯示胎盤衍生間質幹細胞具免疫調節特性，在資源有限環境下可作為支持性照護的輔助療法提升存活。
Glucagon-like Peptide-1 Receptor Agonists in Obese Left Ventricular Assist Device Recipients: A Propensity-Matched Real-World Cohort Study.
回顧性研究分析肥胖LVAD植入患者使用GLP-1 RA的效果，探討對全因死亡率、導線感染及心臟移植名單登錄的影響。
Pharmacologic and Non-Pharmacologic Interventions for Hypothalamic Obesity: An Updated Review.
回顧下丘腦肥胖治療策略，涵蓋新診斷標準、Setmelanotide等新藥、代謝減重手術及新興療法，強調長期管理挑戰。
Driving pressure-guided individualized PEEP versus fixed low PEEP in obese patients undergoing bariatric surgery: a randomized clinical trial.
116名減重手術患者隨機試驗，比較驅動壓導向個別化PEEP與傳統固定低PEEP對術後肺併發症的影響。
Registered Dietitian Nutritionists and Medical Nutrition Therapy: A Recipe for Improving Kidney Disease Care and Outcomes.
探討CKD營養教育從限制營養素轉向鼓勵植物性飲食模式，強調改善整體飲食品質可管理糖尿病、高血壓、肥胖等合併症。
EXPRESS: Investigating Body Image Disturbance among Syrian Refugees in Northern Jordan.
調查487名敘利亞難民的身體意象障礙與體重知覺，發現男性過重與肥胖率高於女性，反映弱勢族群獨特健康挑戰。
Hispanic Parent Preferences for Approaching the Weight of Their 8-12-Year-Old Child: A Qualitative Study.
訪談16名西語裔家長，發現家長會考量文化背景決定如何處理兒童體重，偏好融入家庭價值的溫和方式。
Cell-type-specific m1A dynamics are associated with microglial phenotypic transformation and neuronal metabolic adaptation during spinal cord injury.
分析脊髓損傷後m1A修飾變化，發現小膠質細胞與神經元變化最顯著，與細胞表型轉換及代謝適應相關。
Comparison of non-insulin glucose-lowering therapies on coronary atherosclerotic plaque progression in diabetes.
880名T2DM患者CCTA追蹤顯示GLP-1 RA在延緩冠狀動脈斑塊進展方面最優，提供心血管保護直接影像學證據。
BCAA metabolic reprogramming identifies BCKDK as a therapeutic target in cancer.
回顧BCKDK在BCAA分解代謝的調控角色，探討其作為腫瘤代謝重編程與治療抗性靶點的潛力與抑制劑開發進展。
BODY-Q-7D Measures Consensus-Based Patient-Reported Outcomes for the Management of Obesity Treatment.
開發BODY-Q-7D量表涵蓋自尊、身心理社會健康、飲食、污名化、身體意象及多餘皮膚等八個領域，供減重研究使用。
Finding Balance: Insights from Mexican Heritage Families on Living a Healthy Lifestyle in New York City.
聚焦組訪談31名紐約墨西哥裔家長，識別文化融合、家庭動態、環境障礙與社區資源四大主題，作為家族介入設計基礎。
Semaglutide for prevention of type 2 diabetes in women with postpartum prediabetes after gestational diabetes: protocol for a Belgian multicentre double-blind randomised placebo-controlled trial.
SERENA試驗評估Semaglutide在GDM後產後前期糖尿病女性預防T2DM的療效與安全性，為高風險族群提供藥物預防策略。
One receptor, two opposite approaches: efficacy and tolerability of GIPR agonism and antagonism in obesity pharmacotherapy.
探討GIP受體激動與拮抗皆顯減重效果的悖論，分析Tirzepatide與MariTide機制，為下一代肥胖藥物開發提供理論基礎。
[Transmesenteric Hernia: A Rare, Surgically Treatable Cause of Chronic Gastrointestinal Symptoms].
報告78歲女性兩年減重27公斤的案例，影像顯示漩渦徵象，腹腔鏡確認為腸繫膜裂孔疝氣，手術治療後症狀解除。
Exploring the Feasibility, Acceptability, and Safety of a 4:3 Intermittent Fasting Weight Loss Program Among Stage I-III Breast Cancer Survivors With Overweight or Obesity: Protocol for a 6-Month Proof-of-Concept Feasibility Trial.
針對約70%有過重或肥胖的乳癌存活者，設計6個月4:3間歇性斷食可行性試驗，尋求創新減重策略。
Exercise training attenuates high-fat diet-induced skeletal muscle atrophy by inhibiting Drp1-mediated cuproptosis in male mice.
小鼠實驗證實有氧運動可抑制Drp1介導的銅凋亡，改善高脂飲食造成的骨骼肌萎縮，為肥胖相關肌少症提供運動介入理論基礎。
Association of the sulfur microbial diet with metabolic profile, gut-related biomarkers, and adiposity indicators in adults with overweight and obesity.
探討高加工肉品、酒精與人工甜味劑的硫微生物飲食與腸道菌相失衡、LPS、NGF及代謝風險因子的關聯。
Adolescent food insecurity impairs gut signal sensitivity and cue-induced appetitive behaviours in female rats.
大鼠模型證實食物不安全感會損害腸道飽食信號敏感度並增強線索驅動的進食反應，解釋食物不安全與肥胖的因果機制。
Impact of semaglutide on cognitive function in patients with type 2 diabetes and mild cognitive impairment: a 24-month observational study.
24個月追蹤72名T2DM合併MCI患者，評估Semaglutide對認知功能的影響，探討GLP-1 RA的潛在神經保護效果。
Compartmental pH regulation in cancer and antitumor immunity: therapeutic opportunities and challenges.
探討腫瘤細胞pH穩態失衡特徵，分析pH調控如何影響腫瘤生長、免疫逃逸及治療抗性，以及相關治療策略。
Effects of Functional Training on Body Composition in Adults with Overweight or Obesity: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
系統性回顧分析功能性訓練包含高強度功能性訓練與CrossFit等對過重者身體組成的效果。
High-Protein Diet Combined With Improves Weight Loss, Lipid Metabolism, and Gut Microbiota in Obese Rats.
大鼠實驗顯示乳清蛋白高蛋白飲食結合乳酸桿菌可減少攝食量、促進體重下降、減少內臟脂肪並改善腸道菌相。
Phytochemical Profiling and Evaluation of Antioxidant and Enzyme Inhibitory Activities of Selected Endemic Species (Lamiaceae) From Türkiye.
分析土耳其特有鼠尾草屬植物的植化成分，評估其α-葡萄糖苷酶、α-澱粉酶與胰脂肪酶抑制活性，探討抗糖尿病與抗肥胖潛力。
Comparison of lifestyle, surgery, and semaglutide for weight management in endometrial cancer: a prospective observational study.
比較袖狀胃切除、Semaglutide與DEAR計畫於子宮內膜癌保留生育力患者的減重效果，袖狀胃減重幅度最大。
Partial substitution of organic trace minerals in sow diets over multiple parities and the impact on claw health, productivity, and longevity.
探討有機鋅、銅、錳部分替代無機形式對母豬爪部健康、活動評分、泌乳期體重減輕與淘汰率的影響。
Soy protein alleviates DKD by restraining inflammation via the MAPKs/PPAR-γ signaling pathway.
生資訊分析與實驗驗證大豆蛋白透過調節MAPK/PPAR-γ串話抑制發炎，緩解糖尿病腎病變進展。
Combined exercise for body composition and cardiometabolic health in obese young people meta analysis.
29項試驗1383名參與者的統合分析顯示，相較純有氧運動，結合運動在瘦體質量與胰島素抵抗指標改善上更優。
Oral-gut strain sharing after Roux-en-Y gastric bypass: A canonical oral microbiome signature in the gut linked to hepatic and glycemic remodeling.
發現RYGB促進口腔菌株轉移至腸道，這些菌株與肝臟及血糖改善相關，揭示減重手術代謝效益的新機制。
Reactive oxygen species (ROS) in cancer: from redox signaling and metabolic plasticity to therapeutic vulnerabilities.
探討ROS在腫瘤生物學的雙重角色，分析癌細胞抗氧化適應機制與「Nrf2成癮」現象，以及相關治療策略。
Tirzepatide-Induced Weight Loss and Exacerbation of Bipolar Disorder With Clozapine Treatment: A Case Report.
報告Tirzepatide減重期間合併Clozapine治療患者出現雙相情感障礙惡化的案例，提示藥物交互作用風險。
Correction: Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure.
此為前文之更正聲明，原文探討整合中樞食慾調節與周邊能量消耗的肥胖協同治療策略。