2026年5月14日（星期四）
本日收錄 40 篇文獻Pasteurized Akkermansia muciniphila Mucfor weight loss maintenance in people with overweight and obesity: a controlled randomized trial.
本研究發表於Nature Medicine，探討腸道共生菌Akkermansia muciniphila（經巴氏殺菌處理）在體重維持期的效果。90名過重/肥胖成人先進行8週低熱量飲食減重≥8%，隨後24週隨機分組每日補充Muc或安慰劑。結果顯示Muc組體重反彈顯著低於安慰劑組（1.2±0.7 kg vs 3.2±0.4 kg，P=0.012），且從基線到維持期結束的淨減重更多。此研究為微生態調節作為體重維持策略提供重要臨床證據。
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial.
本研究發表於Nature Medicine，評估口服非胜肽GLP-1受體激動劑Orforglipron在體重維持期的效果。研究納入先前接受Tirzepatide或Semaglutide治療的受試者，隨機分配至Orforglipron或安慰劑組。結果顯示，達到體重高原期的Tirzepatide隊列受試者，轉換至Orforglipron後可維持74.7%的減重效果。此研究證實口服GLP-1 RA可作為注射劑型停藥後的替代維持方案，提升治療便利性。
Tirzepatide for maintenance of bodyweight reduction in people with obesity in the USA (SURMOUNT-MAINTAIN): a multicentre, double-blind, randomised, placebo-controlled trial.
此Lancet發表的3b期試驗評估Tirzepatide不同劑量策略的體重維持效果。受試者先以最大耐受劑量（10或15 mg）治療60週後，隨機分配至繼續MTD、降至5 mg或安慰劑組進行52週維持期。研究證實繼續MTD可最佳維持減重效果，降階至5 mg仍有部分維持效益，而停藥則導致顯著體重反彈。此結果為臨床劑量調整策略提供重要依據。
Pharmacological interventions for the treatment of obesity in children and adolescents.
此Cochrane系統性回顧全面評估兒童青少年肥胖藥物治療的效益與風險。搜尋至2025年6月的文獻，涵蓋減重效果、生活品質及長期不良事件等結果。在生長發育動態變化的兒少族群中，藥物角色仍具不確定性。此回顧為兒科肥胖用藥決策提供最高等級證據基礎，對臨床實務具重要指導意義。
Endoluminal device induces insulin sensitivity and greater weight control than semaglutide in pigs.
此Gut期刊研究報告一種新創內視鏡裝置，在豬隻模型中顯示優於Semaglutide的體重控制效果及胰島素敏感性改善。這項創新治療內視鏡技術為不願或無法接受手術的患者提供潛在的非藥物替代方案。若人體試驗成功，將顛覆現有減重治療格局，具高度臨床轉譯價值。
Integrating Obesity Treatment into Cancer Care: From Missed Opportunity to Standard of Care.
此Annals of Surgery文章探討將肥胖治療（含減重手術與GLP-1藥物）整合至腫瘤護理的必要性。肥胖為多種癌症的風險因子，且影響治療效果與存活率。文章從實施科學角度分析障礙與促進因素，呼籲建立跨科別合作模式。此觀點對腫瘤醫學與減重醫學的整合發展具重要政策意義。
Health Care Costs and Use of Patients Prescribed Four Different Obesity Medications.
此研究利用商業保險理賠資料，比較Phentermine、Phentermine-Topiramate-ER、Naltrexone-Bupropion-SR及Liraglutide四種減重藥物的醫療成本與利用。納入超過22萬名新用藥者，追蹤3年。結果顯示三種較新藥物的處方與總醫療成本均高於Phentermine。此真實世界資料為醫療資源分配與保險給付決策提供重要參考。
Paragonimus proliferus Metacercaria-derived antigens mitigate DSS-Induced Ulcerative Colitis via immunomodulation and gut microbiota reconfiguration.
探討寄生蟲抗原在潰瘍性結腸炎小鼠模型中的保護效果，發現可減少體重流失、降低發炎因子並修復腸道屏障完整性。
Psychosocial outcomes of the Fast Track to Health clinical trial in adolescents with obesity.
評估青少年肥胖者接受4週極低熱量飲食後續接間歇或持續熱量限制的心理社會影響，追蹤52週。
Clinical Presentation and Management Outcomes of Pancreatic Cancer in African Countries: A Scoping Review.
回顧1995-2023年非洲26,850例胰臟癌資料，發現研究分布不均，多集中於南非，揭示報告缺口。
Orlistat potentiates the gemcitabine effect in inhibiting the malignant biological behavior of nasopharyngeal carcinoma by downregulating PKM2.
體內外實驗證實減重藥Orlistat作為FASN抑制劑可增強吉西他濱對鼻咽癌的治療效果。
Implications of Glucagon-Like Peptide-1 Receptor Agonists in Otolaryngology - Head and Neck Surgery: A Review.
回顧GLP-1 RA在頭頸部的影響，包括延遲胃排空導致術中吸入風險，以及治療阻塞型睡眠呼吸暂停的潛力。
Pharmacological interventions for the treatment of obesity in children and adolescents.
Cochrane系統性回顧評估兒少肥胖藥物治療的效益與風險，涵蓋減重效果、生活品質及長期安全性。
Pasteurized Akkermansia muciniphila Mucfor weight loss maintenance in people with overweight and obesity: a controlled randomized trial.
Nature Medicine研究證實補充巴氏殺菌Akkermansia muciniphila可顯著減少體重反彈（1.2 kg vs 3.2 kg）。
Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial.
證實口服GLP-1 RA Orforglipron可作為注射劑型停藥後的替代方案，維持約75%減重效果。
Binge eating, multimorbidity and sociodemographic characteristics are associated with a high prevalence of depression and anxiety in adults with class II and III obesity.
橫斷研究發現150名嚴重肥胖成人中，暴食障礙與多病共存為憂鬱焦慮的重要相關因素。
Sijunzi Decoction Reverses Metabolic Adaptation and Induces Ferroptosis in Cisplatin-Resistant Non-small Cell Lung Cancer: An Integrative Metabolomics-Pharmacology Analysis.
運用多組學整合分析探討四君子湯克服肺癌化療抗藥性的機制，與減重無直接關聯。
Metabolic Dysfunction-Associated Steatotic Liver Disease and Cardiovascular Disease: Shared Mechanisms and Therapeutic Opportunities.
回顧MASLD與心血管疾病的共同病理機制，探討GLP-1 RA、SGLT2抑制劑等藥物的治療潛力。
Associations Between Weight Loss Prior to Knee and Hip Arthroplasty and Peri- and Post-Operative Outcomes: A Systematic Review and Meta-Analysis.
評估術前減重是否可降低關節置換術後併發症風險，結果顯示減重對改善部分結果有限。
Bio-based sulfur copolymers from unsaturated oils: comparative study of safflower and linseed oils for Reactive Black 5 removal.
開發廢水處理用生物基吸附材料，與減重主題無關。
AZD6738 overcomes acquired olaparib resistance in BRCA1 mutation triple-negative breast cancer through down-regulation of BRCA2 and RAD51.
探討ATR抑制劑與PARP抑制劑聯合治療乳癌抗藥性的機制，與減重無直接關聯。
Health Care Costs and Use of Patients Prescribed Four Different Obesity Medications.
超過22萬名患者的真實世界資料顯示，三種較新減重藥物成本均高於Phentermine。
Tirzepatide for maintenance of bodyweight reduction in people with obesity in the USA (SURMOUNT-MAINTAIN): a multicentre, double-blind, randomised, placebo-controlled trial.
3b期試驗證實繼續Tirzepatide MTD可最佳維持減重效果，降階至5 mg仍有部分效益。
Biomaterial-Driven Therapeutic Strategies for the Integrated Management of Obesity.
回顧奈米載體、巨載體等生醫材料平台在抗肥胖治療中的最新進展與設計原則。
Single Anastomosis Sleeve Ileal Bypass Could Be the Future of Redo Surgery? A Single-Center Cohort Study.
評估SASI作為初次減重手術後體重復胖或效果不佳患者的修復手術選擇，顯示良好效果。
Sex-specific systemic and brain metabolic responses to a standardized ketogenic diet in mice.
發現雌雄小鼠對生酮飲食反應顯著不同，雌鼠較瘦、基礎酮體較高且減重變異性大。
Determinants of obesity: The role of sociodemographic factors, health behaviors, and quality of life in Spanish workers.
橫斷研究分析10萬名西班牙工作者的肥胖相關因素，比較BMI與其他脂肪指標的預測價值。
Participatory methodologies in food and nutrition education: perceptions of healthy habits and eating behavior in children and their families.
探討對話式參與方法在營養教育中的應用，發現可增強家庭參與及行為改變效果。
Integrative analysis of the mouse cecal microbiome across diet, age, and weight in the diverse BXD population.
運用多組學方法解析飲食、年齡、遺傳對腸道菌群的交互影響及其與宿主表型的關聯。
Peripheral cholecystokinin promotes thermogenesis via vagal afferent signalling, hypothalamic oxytocin and sympathetic outflow to brown adipose tissue.
闡明腸道激素CCK活化迷走神經後，經下視丘催產素路徑促進棕色脂肪組織產熱的完整神經回路。
Glucagon-like peptide-1 receptor agonists improve hepatic histology and metabolic parameters in type 2 diabetes with MASLD: a meta-analysis of randomized controlled trials.
11項RCT薈萃分析證實GLP-1 RA可改善合併MASLD之2型糖尿病患者的肝脂肪、血糖控制與脂質代謝。
Prepregnancy GLP-1RA Exposure and Risk of Hypertensive Disorders of Pregnancy Among Women With Obesity and Diabetes.
回溯性隊列研究評估孕前使用GLP-1 RA對妊娠高血壓疾病的影響，提供用藥安全性資訊。
Epitranscriptomic control of cancer: the emerging roles of m5C and ac4C RNA modifications.
探討RNA胞嘧啶修飾在腫瘤代謝適應與免疫逃逸中的調控機制，與減重無直接關聯。
Sleep, lipids, and metabolic health in the Indian obesity epidemic: an integrative review of mechanisms, burden, and breakthroughs.
回顧印度族群睡眠健康與代謝疾病的關聯，強調「亞洲印度表型」在較低BMI即出現高代謝風險。
Cardiac computed tomography unmasks cardiac involvement in immune complex vasculitis in a patient with chest pain and shortness of breath.
病例報告描述血管炎患者合併體重減輕，與減重主題僅間接相關。
Effect of Different Modes of High Intensity Interval Training on Appetite-Related Hormones, Appetite Perception, and Anthropometric Measures in Overweight and Obese Men: A Randomized Controlled Trial.
隨機試驗比較HIIT與HIFT對食慾激素（Ghrelin、PYY、GLP-1）的影響，兩組均有正面效果。
Clinical Reasoning: A 55-Year-Old Man With Rapidly Progressive Weakness and Numbness.
神經系統病例報告，體重減輕為症狀之一，與減重主題僅間接相關。
Optimizing Breast Cancer Survivorship: Addressing Lifestyle, Weight Management, and Psychological Health.
探討乳癌存活者照護三大支柱：生活型態醫學、體重管理與心理福祉的實務策略。
Targeting Cancer Cachexia: A Mechanistic Evaluation of Anti-GDF-15 Antibody-Based Combination Therapies.
小鼠模型評估抗GDF-15抗體與肌肉合成代謝劑或食慾刺激劑聯合治療惡病質的效果。
Relationship between remission rate of type 2 diabetes and skeletal muscle after laparoscopic sleeve gastrectomy.
回溯性研究發現袖狀胃切除術後骨骼肌質量與2型糖尿病緩解率具相關性。
Molecular Dialogues in the Mitochondria-Microbiome Crosstalk: Metabolites, Signaling, and Immunity.
回顧線粒體-微生物組軸的雙向調控機制，及其在肥胖等代謝疾病的病理角色。
Aggregation-driven expression of liraglutide precursors using engineered mini-tags in Escherichia coli.
開發11種微型融合標籤提升利拉魯肽前體在大腸桿菌中的重組表達產量。
Integrating Obesity Treatment into Cancer Care: From Missed Opportunity to Standard of Care.
呼籲建立減重醫學與腫瘤學的跨科別合作模式，將肥胖治療納入癌症標準照護。
Correction to: Bariatric Surgery for Patients Living with Obesity and Left Ventricular Dysfunction: Evaluating Perioperative Safety and Postoperative Functional Outcomes.
文章修正通知，原始研究評估減重手術對心功能障礙肥胖患者的安全性。
Endoluminal device induces insulin sensitivity and greater weight control than semaglutide in pigs.
新創內視鏡裝置在豬隻模型顯示優於Semaglutide的體重控制與胰島素敏感性改善效果。
Challenges in mitigating weight regain with incretin-based therapy.
探討GLP-1等腸促胰島素藥物停用後體重反彈的挑戰與應對策略。
Intermittent Fasting and the Gut Microbiota: A Path to Reducing Obesity-Driven Gut Barrier Dysfunction: A Brief Review.
簡要回顧間歇性斷食透過調節腸道菌群改善肥胖相關腸道屏障功能障礙的機制。