Vascular Dementia Daily Research Report
2026年7月31日
VasCog-2-WSO Criteria for Vascular Cognitive Impairment and Dementia: A Revised Standard Put to the Test.
Neurology
最新 VasCog‑2‑WSO 標準在臨床驗證中提升診斷特異性與感受性，推動 VCI/VCI 診斷的一致性與實務應用。
💡 標準化診斷工具可直接應用於臨床篩選與研究設計
查看原文 →Association of combined physical and cognitive rehabilitation with post-stroke dementia: a U.S. multicenter retrospective cohort study.
Arch Phys Med Rehabil
多中心回顧研究顯示，合併身體與認知復健可降低中風後認知衰退風險 28%，建議將其納入標準護理路徑。
💡 證實多模式復健能實質降低中風後失智風險，具可操作性。
查看原文 →The role of glymphatic dysfunction in cerebral small vessel disease and vascular cognitive impairment, and therapeutic implications.
Int J Stroke
闡明 glymphatic 失調在小血管病變與 VCI 中的核心機制，探討清除途徑調節劑作為潛在治療方向。
💡 機制發現為後續治療開發提供生物標記與藥物目標。
查看原文 →Advances in pharmacotherapy for vascular cognitive impairment and vascular dementia: An update of 2025.
Alzheimers Dement (N Y)
系統性細目檢視彙總近五年新藥物（如 TLR4 抑制劑、PARP1 抑制劑）對 VCI/VCI 的臨床試驗進展與安全性。
💡 為臨床研發提供候選藥物，但需更多大型試驗驗證。
查看原文 →Correction: Altered T1w/T2w-FLAIR Ratio in White Matter Hyperintensities as an Indicator of Structural Integrity Loss: Association with Alzheimer's Disease and Vascular Dementia
提出 T1w/T2w-FLAIR 量測作為白質病變結構完整性指標，與 AD 與 VCI 病情顯著相關，具潛在影像生物標記價值。
💡 簡單影像參數即可預測混合型與血管型失智風險，易於臨床檢驗。
查看原文 →Animal models of ischemic cerebral small vessel disease: A narrative review of pathological phenotypes, challenges, and future directions.
Exp Neurol
全面評論目前小血管病變模型的生理病理差異，凸顯缺乏標準化血流量與血管重塑評估，提出未來需整合多模態 MRI 的新模型。
💡 可指引更具預測價值的動物模型設計，減少資源浪費。
查看原文 →The role of glymphatic dysfunction in cerebral small vessel disease and vascular cognitive impairment, and therapeutic implications.
Neurobiol Dis
證實 glymphatic 障礙與血管負荷驅動認知衰退，探討刺激 glymphatic 以減緩 VCI 的潛在療法。
💡 仍屬前期實驗階段，臨床應用尚未成熟。
查看原文 →Prediction Model for Mild Cognitive Impairment in Older Chinese Patients With Cerebral Small Vessel Disease Based on XGBoost Algorithms and Shapley Additive Explanations.
CNS Neurosci Ther
利用機器學習建置 XGBoost 診斷模型，可在 6 個月內預測 MCI 風險，並透過 SHAP 解讀關鍵危險因子。
💡 可協助早期篩選與個體化預防，但需要外部驗證。
查看原文 →Advances in pharmacotherapy for vascular cognitive impairment and vascular dementia: An update of 2025.
Alzheimers Dement (N Y)
細目檢視彙總新近抗發炎、免疫調節劑的臨床試驗。
查看原文 →Association of combined physical and cognitive rehabilitation with post-stroke dementia: a U.S. multicenter retrospective cohort study.
Arch Phys Med Rehabil
中風後接受多模式復健可降低 28% 失智風險。
查看原文 →The role of glymphatic dysfunction in cerebral small vessel disease and vascular cognitive impairment, and therapeutic implications.
Int J Stroke
glymphatic 失調與小血管病變、VCI 的關聯，探討治療策略。
查看原文 →Pentoxifylline targets TLR4/MyD88/NF-κB signaling to ameliorate neuroinflammation and metabolic dysfunction in a rat model of chronic hypoperfusion-induced vascular cognitive impairment.
Metab Brain Dis
Pentoxifylline 抑制 TLR4/MyD88/NF‑κB 抑制腦部發炎與代謝紊亂。
查看原文 →A Study on the Effects of Intranasally Administered Liquid Crystalline Nanoparticles Loaded with Salvianolic Acid B in Vascular Dementia.
Mol Neurobiol
液晶納米粒子鼻內給藥改善血管性痴呆之神經行為。
查看原文 →PARP1–FOXO3a–Depp1 signaling axis Drives Blood–Brain Barrier Disruption Under Chronic Cerebral Hypoperfusion by Triggering Excessive Autophagy Initiation
發現新機制，解釋慢性腦供血不足下 BBB 破壞與自體磁動作過度。
查看原文 →Subcutaneous transplantation of lung organoids ameliorates vascular dementia via the IGFBP7-Ago2 mediated lung-brain axis.
J Neuroinflammation
肺類器官移植改善血管性痴呆，透過 IGFBP7‑Ago2 軸。
查看原文 →Research progress on horticultural therapy in patients with post-stroke cognitive impairment: a narrative review.
Top Stroke Rehabil
園藝療法對中風後認知障礙的效益與實作方案。
查看原文 →Protecting the brain from post-stroke cognitive impairment and dementia with multimodal exercise training: study protocol for a Bayesian adaptive trial (PROTECT).
BMJ Open
多模式運動訓練的 Baynesian 設計試驗方案。
查看原文 →Better cardiovascular health, measured by Life's Simple 7, is associated with lower white matter hyperintensity burden and greater cerebral blood flow over time.
J Alzheimers Dis
Life's Simple 7 高分與 WMH 較少、腦血流較高，支持心血管風險管理。
查看原文 →Automated quantification of white matter hyperintensity confluence: A measure of spatial organisation beyond volume and visual rating scales
提出自動化 WMI 聚集度指標，提供比傳統量化更細緻的脈絡。
查看原文 →