Vascular Dementia Daily Research Report
2026年6月30日
Modifiable and clinically actionable exposures for vascular dementia: a structured evidence synthesis of Mendelian randomization studies.
J Neurol
透過孟德爾隨機化研究確認吸菸、高血壓等因子對血管型失智症的因果關係，為臨床預防提供高階證據。
💡 明確界定具有因果關係的預防因子，可直接指導高危險群患者的衛教與風險控制。
查看原文 →Developing a core outcome set for intervention studies in post stroke cognitive impairment (COS-PSCI): a protocol.
BMJ Open
制定中風後認知障礙介入研究的標準化評估指標，以利未來臨床試驗結果的比較與整合。
💡 標準化評估指標有助於提升臨床試驗品質，讓醫師更能準確判讀不同療法的有效性。
查看原文 →Hypertensive Disorders of Pregnancy Associated With Cerebral Small Vessel Disease Decades Later.
J Am Heart Assoc
揭示妊娠高血壓疾病是晚年腦小血管疾病的顯著風險因子，強調女性生命早期心血管健康的重要性。
💡 為神經內科與婦產科提供跨世代預防策略的依據，有助於早期識別高危險女性。
查看原文 →Joint association of a healthy low-carbohydrate diet and frailty with the risk of incident Alzheimer's disease and vascular dementia: a prospective cohort study
Front Public Health
顯示健康低碳水化合物飲食結合非虛弱狀態，能顯著降低失智症發生風險。
💡 提供具體且可執行的飲食與體能建議，強調營養與肌少症/虛弱預防在失智症防治中的角色。
Development and validation of a diagnostic model for mild cognitive impairment in patients with type 2 diabetes mellitus and concomitant white matter hyperintensities.
BMC Neurol
建立針對常見共病（糖尿病+腦白質病變）患者的 MCI 診斷預測模型，提升早期篩檢效率。
💡 糖尿病與腦白質病變高度共存，此模型可協助內科醫師在門診快速篩選需轉介認知評估的病患。
查看原文 →Incidental DWI-Positive Lesions in 2 Cohorts of CAA and CADASIL: Prevalence, Distribution, and Associations With Clinical Variables.
Neurology
比較腦類澱粉血管病變與 CADASIL 患者中無症狀急性微梗塞的影像特徵與臨床意義。
💡 有助於臨床醫師透過 MRI 影像區分不同類型的腦小血管疾病及其活動性。
查看原文 →Interleukin-6 is associated with white matter hyperintensities and cognition independent of Alzheimer's disease plasma biomarkers-HABS-HD.
J Alzheimers Dis
證實發炎指標 IL-6 與腦白質病變及認知下降直接相關，且此機制獨立於 AD 病理。
💡 強調控制全身性發炎對保護血管認知功能的重要性，支持抗發炎療法的潛力。
查看原文 →From artery to memory: a comparative review of vascular cognitive impairment surgical models
Front Aging Neurosci
回顧用於研究血管型認知障礙的各種動物手術模型，分析其病理機制與臨床相關性。
Mapping the multi-scale landscape of vascular cognitive impairment: from structural atrophy networks to cellular and neurochemical substrates.
J Neurol
整合宏觀腦結構網絡與微觀細胞變化，全面解析 VCI 的病理生理機制。
查看原文 →Gastrodin ameliorates cognitive impairment induced by a high-salt diet combined with chronic cerebral hypoperfusion by regulating cerebral blood flow and preserving BBB-related structural integrity.
J Ethnopharmacol
動物實驗顯示天麻素可透過保護血腦屏障與調節血流，改善由高鹽飲食與低灌流造成的認知損傷。
查看原文 →Electroacupuncture Ameliorates Neuroinflammatory Damage and Cognitive Impairment in Vascular Dementia by Promoting Shh Signaling-Mediated Microglial M2 Polarization.
Neurochem Res
研究證實電針透過調節神經發炎反應與小膠細胞極化狀態來改善血管型失智症。
查看原文 →Plasma miR-34a-5p outperforms miR-126-3p in predicting cognitive decline in cerebral small vessel disease patients with impaired glucose regulation
Front Aging Neurosci
發現 miR-34a-5p 是預測合併糖代謝異常之 CSVD 患者認知惡化的潛力生物標記。
Electroacupuncture treatment enhances hippocampal growth hormone level and restores mitochondrial function in vascular dementia rats.
Brain Res
探討電針改善血管型失智症認知功能的分子機制，涉及生長激素與線粒體功能修復。
查看原文 →Deep white matter injury and cognitive decline in cerebral small vessel disease: Mediation by a unified atrophy network.
J Alzheimers Dis
揭示腦萎縮網絡是連接深部白質損傷與認知功能下降的關鍵中介路徑。
查看原文 →Corrigendum to "Guipi Tang alleviates vascular dementia by regulating purine metabolism via gut microbiota-derived pantothenic acid" [Phytomedicine volume 148 (2025) 157297].
Phytomedicine
針對先前關於歸脾湯治療血管型失智症機制研究的勘誤聲明。
查看原文 →Disrupted white matter functional connectivity in post-stroke cognitive impairment: Insights from resting-state fMRI.
Brain Imaging Behav
利用 fMRI 分析中風後認知障礙患者白質功能連接的異常模式。
查看原文 →Norms for Automatic Estimation of White Matter Hyperintensities Burden: LST-AI Service in NeuGRID
提出利用 AI 工具自動量化白質高強度病灶的臨床規範值。
查看原文 →L-Arginine and Its Metabolites in Age-Related Cerebral Small Vessel Disease with Cognitive Impairment.
Biomolecules
探討 L-精氨酸代謝途徑在腦小血管疾病認知障礙病理中的變化。
查看原文 →Premature Aortic Stiffness in Relation to Cerebral Small Vessel Disease, Cognitive Decline, Major Cardiovascular Events and Mortality in Dialysis.
Am J Nephrol
指出透析患者的主動脈僵硬與腦部病變及認知衰退密切相關。
查看原文 →Clinical and neuroimaging correlates of motoric cognitive risk syndrome in cerebral small vessel disease: a cross-sectional study
Front Aging Neurosci
分析腦小血管疾病患者出現運動認知風險症候群的特徵與對應的腦部變化。
Myelin-driven structural network redundancy underlies cognition in cerebral small vessel disease.
Alzheimers Res Ther
強調髓鞘完整性與結構網絡冗餘度在維持 CSVD 患者認知功能中的重要性。
查看原文 →Impact of white matter hyperintensities on cognitive, motor and functional recovery in veterans following acute/subacute stroke: a prospective study.
BMJ Neurol Open
前瞻性研究顯示既有腦白質病變會惡化中風後的復原結果。
查看原文 →Obesity, White Matter Hyperintensities, and Cognitive Decline: Sex-Specific DTI-ALPS Index Mediation.
Stroke
探討肥胖透過影響類淋巴系統功能（ALPS 指數）導致白質病變與認知下降的性別差異。
查看原文 →