Vascular Dementia Daily Research Report
2026年5月22日
TDCS Modulates Inflammatory Markers to Improve Post-Stroke Cognitive Impairment and Depression: An Exploratory Randomized Trial.
Neurorehabil Neural Repair
本項隨機試驗證實經顱直流電刺激不僅能改善中風後患者的認知功能與憂鬱症狀，還顯著調節了發炎生物標記，為非侵入性腦刺激治療提供了抗炎機制證據。
💡 隨機對照試驗證實了 tDCS 的臨床療效並闡明其免疫機制，具有直接轉化至復健臨床的潛力。
查看原文 →Deep Learning for Classifying and Cognitive Profiling of Subcortical Vascular Cognitive Impairment.
Cyborg Bionic Syst
研究開發了一種深度學習演算法，能精準分類皮質下血管型認知障礙並建立患者的認知特徵檔案，展現了 AI 在輔助複雜神經退行性疾病診斷的強大能力。
💡 雖仍處於驗證階段，但該技術未來可大幅提升診斷效率並個別化評估認知損傷模式。
查看原文 →Plasma extracellular vesicle proteins biomarker for cerebral small vessel disease related cognitive impairment.
Alzheimers Res Ther
研究鑑定出血漿胞外囊泡中的特定蛋白質，作為腦小血管疾病相關認知障礙的潛在生物標記，為早期篩檢與疾病監測提供無創新工具。
💡 血液生物標記是早期診斷的關鍵趨勢，此研究朝向臨床液態活检邁進一步，但需更多驗證。
查看原文 →Adiponectin Fortifies White Matter After Chronic Hypoperfusion-Induced Vascular Dementia.
Stroke
動物研究顯示脂聯素具有神經保護作用，能減緩慢性腦血流不足引起的白質損傷。
查看原文 →Identifying targets at the blood-brain barrier for treating vascular cognitive impairment and dementia.
Expert Opin Ther Targets
綜述文章探討血腦屏障作為治療血管型認知障礙與失智症的關鍵藥物靶點。
查看原文 →Neuroprotective effects of piracetam in vascular dementia: a review of toll-like receptor 4 -mediated neuroinflammatory pathways.
Inflammopharmacology
文章探討吡拉西坦如何透過調節 TLR4 介導的神經發炎通路來發揮神經保護作用。
查看原文 →Peripheral biomarkers of neuroinflammation in Alzheimer's disease and vascular dementia.
Biochem Pharmacol
分析比較阿茲海默症與血管型失智症中，反映神經發炎狀態的周邊血液生物標記。
查看原文 →Role of disturbed structural connectivity network in patients with white matter lesions and cognitive impairment revealed by diffusion-tensor magnetic resonance imaging.
J Int Med Res
利用 DTI 影像技術分析白質病變患者腦部結構連接網絡的異常及其與認知障礙的關聯。
查看原文 →Overexpressing GPX4 attenuates cognitive decline in chronic cerebral hypoperfusion via suppression of ferroptosis-driven neuroinflammation and white matter injury.
Brain Res Bull
研究發現提升 GPX4 表現可抑制鐵死亡與發炎反應，從而保護慢性腦缺血下的認知功能。
查看原文 →Transcriptomic Evidence of MAS1 Receptor Dysregulation and a Failed Compensatory State in Human Vascular Cognitive Impairment
medRxiv
轉錄組分析揭示 MAS1 受體在人類 VCI 中調控異常，且疾病狀態下代償機制失敗。
查看原文 →Aspects of providing care for individuals with vascular dementia - a caregiver's perspective.
BMC Geriatr
探討照護者對於血管型失智症患者照護過程中的經驗、挑戰與需求。
查看原文 →The lung-brain axis mediates the neuroprotective effects of nasally administered L. salivarius and its EV-delivered metabolite in vascular dementia.
J Neuroinflammation
研究提出透過鼻內給予特定益生菌及其胞外囊泡代謝物，經由肺-腦軸發揮神經保護功效。
查看原文 →Correction: Genetic Evidence Supports a Potential Role of WTAP-related m6A Regulation in Vascular Dementia: Insights from Mendelian Randomization and Multi-omics Analyses.
J Mol Neurosci
對先前關於 WTAP 與 m6A 調控在血管型失智症中作用的遺傳學研究進行更正。
查看原文 →Tripeptidyl peptidase II is essential for maintaining cerebrovascular homeostasis of female mice and represents a novel therapeutic target for vascular dementia
Preprint
發現 TPP2 對維持雌性小鼠腦血管恆定性不可或缺，是潛在的 VaD 治療標的。
查看原文 →Attenuated Task-Related Changes of Heart-Brain Coupling During Cognitive Load in Post-Stroke Cognitive Impairment: An EEG-ECG Maximal Information Coefficient Study.
IEEE Trans Neural Syst Rehabil Eng
研究指出中風後認知障礙患者在進行認知任務時，心腦耦合動態變化減弱。
查看原文 →High-definition Transcranial Direct Current Stimulation Improves Cognitive Function in Patients with Cerebral Small Vessel Disease: An Open-label Pilot Study Informed by Cross-sectional Analysis.
Curr Neuropharmacol
先導性研究顯示 HD-tDCS 能有效改善 CSVD 患者的認知功能，且效果受特定神經影像特徵指導。
查看原文 →Association between individual cerebral small vessel disease MRI markers and neuropsychological performance in amnestic mild cognitive impairment: an exploratory study.
J Neurol
探索不同 CSVD 的 MRI 標記與遺忘型輕度認知障礙患者神經心理學測驗結果的具體關聯。
查看原文 →Clinical factors associated with cognitive impairment in cerebral small vessel disease: a retrospective study.
BMC Neurol
回顧分析確認了與腦小血管疾病患者認知障礙發生相關的臨床危險因子。
查看原文 →Authors' reply to: 'High-Risk Carotid Plaque and Cognition: Cerebral Small Vessel Disease, Statin Intensity, and the Asymptomatic Paradox'.
Eur J Prev Cardiol
作者針對頸動脈斑塊、腦小血管疾病與認知功能之間的關聯及他汀類藥物角色進行回覆討論。
查看原文 →Progression of cerebral small vessel disease in maintenance hemodialysis patients: a prospective cohort study
Preprint
前瞻性隊列研究追蹤接受維持性血液透析患者其 CSVD 的進展情況。
查看原文 →HTRA1 deficiency in <i>COL4A1</i> mutant hiPSC-derived astrocytes, a convergent mechanism of cerebral small vessel disease
Preprint
利用 iPSC 模型發現 COL4A1 突變導致的星形膠質細胞 HTRA1 缺陷是 CSVD 的共同致病路徑。
查看原文 →White Matter Hyperintensity Burden and Short-Interval Change Associated With Sleep Apnoea in the UK Biobank.
Ann Clin Transl Neurol
基於大數據分析顯示睡眠呼吸中止症與白質高強度負荷及其快速進展顯著相關。
查看原文 →White Matter Hyperintensities Moderate the Association Between Diabetes and Non-AD Brain Atrophy.
Diabetes Care
研究指出白質高強度在糖尿病導致非阿茲海默型腦萎縮的過程中扮演調節角色。
查看原文 →Benchmarking automated segmentation tools for white matter hyperintensities quantification to inform stroke and dementia risk stratification
J Clin Transl Sci
比較並評估多種自動分割工具在量化白質高強度方面的效能，以應用於中風與失智症風險評估。
Wasteosomes accumulate in periventricular white matter hyperintensities and exhibit complex relationships with mixed pathology, sclerotic index, and perivascular space.
Brain Pathol
病理研究發現腦部類淋巴系統的 wasteosomes 積聚於腦室周圍 WMH，且與混合病理密切相關。
查看原文 →Holmes Tremor in CADASIL Responsive to Multi-Targeting Deep Brain Stimulation (DBS): An Educational Case with Video and Electrophysiology.
Tremor Other Hyperkinet Mov (N Y)
病例報告展示多目標 DBS 對治療 CADASIL 患者罕見的 Holmes 震顯著有效。
查看原文 →Role of Electroencephalographic Biomarkers as Predictors of Post-Stroke Cognitive Outcomes in Patients with Cerebral Infarction: Literature Review.
Neuropsychiatr Dis Treat
回顧文獻探討 EEG 生物標記在預測腦梗塞患者中風後認知結果中的應用價值。
查看原文 →