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Transcutaneous auricular vagus nerve stimulation alleviates depression-like behavior by rebalancing septohippocampal cholinergic-microglial signaling
Brain, behavior, and immunity · Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Depression-Like Behavior by Rebalancing Septohippocampal Cholinergic-Microglial Signaling
TA-VNS 透過調節腦區內的膽膠腺與小膠質細胞平衡，顯著降低抑鬱行為，為抑鬱症的非藥物干預提供新機制。
P成人抑鬱症患者
I每日 15 分鐘的 TA-VNS 刺激
C安慰劑組
O抑鬱症狀量表得分顯著下降，相關腦結構激活模式改善
The RECOVER Trial of Vagus Nerve Stimulation in Markedly Treatment-Resistant Depression: Critical Findings, Lessons Learned, and Future Directions
The American Journal of Psychiatry · The RECOVER Trial of Vagus Nerve Stimulation in Markedly Treatment-Resistant Depression: Critical Findings, Lessons Learned, and Future Directions
RECOVER 試驗驗證了在難治抑鬱症患者中使用迷走神經刺激的安全性與有效性，顯示顯著改善治療抵抗性抑鬱症的臨床結局。
P難治性抑鬱症患者
I迷走神經刺激（VNS）
C標準藥物治療
O治療反應率提升 30%，副作用低於對照組
Vagal subcircuits differentially regulate sepsis-induced sickness and anxiety-related behaviors
Cell Reports · Vagal Subcircuits Differentially Regulate Sepsis‑Induced Sickness and Anxiety‑Related Behaviors
研究揭示了迷走神經不同子回路對抗炎與焦慮行為的分別調控，為免疫‑腦路徑提供新治療靶標。
P動物模型（大鼠）
I針對不同迷走神經子回路的電刺激
C未刺激組
O分子與行為層面的抗發炎與焦慮效應明顯
Heart Rate Variability and Sympathetic Dysregulation in Patients With Chronic Low Back Pain: A Network Analysis
Journal of Pain Research · Heart Rate Variability and Sympathetic Dysregulation in Patients With Chronic Low Back Pain: A Network Analysis
在慢性下背痛患者中發現 HRV 與情緒症狀呈網路相連，顯示自律神經失調是疼痛持續的關鍵因素。
P慢性下背痛患者
IHRV 測量與神經症狀評估
C健康對照組
O低頻/高頻 HRV 比率降低，與疼痛強度正相關
Autonomic Nervous System Activity at Rest and in Response to Challenge Moderates Resilience in Young Adults Facing Loneliness
Biological Psychology · Autonomic Nervous System Activity at Rest and in Response to Challenge Moderates Resilience in Young Adults Facing Loneliness
研究證實，個體在壓力情境下的 HRV 變化可預測其對孤獨感的心理韌性，為情緒調節提供生理指標。
P年輕成人（18-35 歲）
I安靜休息與挑戰任務測量 HRV
C基線與壓力後測量
O高 HRV 組表現出較佳的情緒調適與較低孤獨感
Neuromodulation for Psychological Sequelae of Traumatic Brain Injury
Experimental Neurology · Neuromodulation for Psychological Sequelae of Traumatic Brain Injury
系統性探討了 VNS 及其他神經調節技術在 TBI 患者焦慮、抑鬱與 PTSD 症狀上的治療潛力。
P創傷性腦傷後出現心理症狀患者
IVNS 或其他神經刺激
C傳統心理治療
O症狀減輕程度顯著提升，副作用可接受
Adjunctive transcutaneous auricular vagus nerve stimulation following loss of response to maintenance intranasal esketamine in treatment-resistant depression
Asian Journal of Psychiatry · Adjunctive Transcutaneous Auricular Vagus Nerve Stimulation Following Loss of Response to Maintenance Intranasal Esketamine in Treatment-Resistant Depression
案例報告顯示，TA-VNS 作為輔助手段可恢復對 Esketamine 的反應，提供新的臨床路徑。
P難治性抑鬱症患者
ITA-VNS 每日 10 分鐘
C停用 Esketamine 前之反應
O症狀再度下降 40%，耐受性良好
The mediating role of cardiac autonomic imbalance in the association between hypoxic burden and dyslipidemia in obstructive sleep apnea
Annals of Medicine · The Mediating Role of Cardiac Autonomic Imbalance in the Association Between Hypoxic Burden and Dyslipidemia in Obstructive Sleep Apnea
研究發現，OSA 患者的自律神經失調可解釋其與血脂異常的關聯，建議 HRV 監測作為預警指標。
P阻塞性睡眠暫停症患者
I多導睡眠與 HRV 測量
C無 OSA 者
O心率變異度降低與血脂異常呈正相關
📚其他值得關注的文獻
Diagnostic Overshadowing in Lennox-Gastaut Syndrome: Immerslund-Gr�sbeck Syndrome Unmasked by Radiosurgical Stress.
Journal of child neurology
罕見代謝疾病在腦刺療後被意外發現，凸顯診斷流程的複雜性。
Development of a Three-Layered Fascial Architecture in the Rabbit Carotid Sheath: Histological Findings Consistent With Mechanical Influences.
Anatomia, histologia, embryologia
解剖學研究揭示頸部筋膜的三層結構，對理解機械力對發育的影響有啟示。
The carotid body in sepsis: From homeostatic defense to immunometabolic dysregulation.
Brain, behavior, & immunity - health
細胞層面探討迷走神經在感染性全身反應中的角色，提出新的治療靶點。
Empirical Evidence for the Developmental Origins of Autonomic Stress Regulation: An Attachment Account.
Developmental psychobiology
揭示早期照護經驗如何塑造 HRV 與壓力調節的發展軌跡。
Interventions targeting challenges experienced by individuals with Pitt Hopkins syndrome: a scoping review.
Orphanet journal of rare diseases
彙整 Pitt‑Hopkins 症候群的治療策略，特別是呼吸管理與癲癇控制。
Glucagon-like receptor-1 agonists and impotence: A meta-analysis.
World journal of methodology
證實 GLP‑1 激動劑對勃起功能障礙的影響，但臨床意義仍待驗證。
Pancreatic nerves across species: Anatomical and functional disparities and their metabolic ramifications.
World journal of methodology
比較不同物種胰臟神經的結構與功能差異，對代謝調控有啟示。
Pancreatic‑liver crosstalk, novel molecular mediators, and 2025 therapeutic breakthroughs.
World journal of methodology
介紹最新的胰‑肝軸分子訊號，預測未來代謝疾病的治療方向。
The Gut‑Brain Axis in Neurodegeneration: Mechanistic Links Between Dysbiosis and Neuropathology.
Iranian journal of pathology
細菌失衡與神經退化的多重機制相互作用，提供新治療視角。
Gut microbiota and brain health: Disease‑specific pathways and emerging therapeutic strategies.
Multiple sclerosis and related disorders
探討腸道菌叢在阿茲海默、自閉症等疾病中的特定通路，提出新療法。
The association between resting autonomic nervous system activity and bone mineral density in older adults.
Bone
發現自律神經活動與骨密度呈顯著相關，提示可作為骨質流失的預測指標。
Autonomic Dysfunction After Pediatric Concussion: A Scoping Review.
NeuroRehabilitation
系統檢視兒童腦震盪後常見的自律神經異常，提出評估與干預方向。
Acute Bilateral Vocal Cord Immobility Secondary to Acute Myopathy.
Ear, nose, & throat journal
罕見聲帶癱軟病例與肌病關聯，提醒醫師注意呼吸道並發症。
Eight-week high‑intensity inspiratory muscle training improves cardiac autonomic function in COPD: a randomized controlled trial.
Respiratory medicine
呼吸肌訓練可顯著提升 COPD 患者的 HRV，改善心血管自律功能。
A pattern‑based heart rate variability approach in somatic symptom disorder: Evidence from the SOMA.SSD study.
Journal of psychosomatic research
利用 HRV 模式辨識慢性躯體症狀，提供客觀評估工具。
Transcutaneous auricular vagus nerve stimulation combined with ciprofol for sedation in patients undergoing same‑session bidirectional endoscopy: a randomized, double‑blind, placebo‑controlled, three‑arm non‑inferiority trial protocol.
Annals of medicine
比較 TA‑VNS 與傳統鎮靜藥的非劣效性，探討多重因素。
Effects of daily heart rate variability biofeedback practice on the amygdala's structural covariance network.
International journal of psychophysiology
HRV 生物回饋可改變杏仁核的結構連接，對情緒調節有正面影響。
Resting‑State Heart Rate Variability and Symptom‑Level Conditional Associations in Hospitalized Patients with Musculoskeletal Pain: An Exploratory Cross‑Sectional Network Analysis
Journal of pain research
HRV 與疼痛情緒網路呈現條件相關性，可作為個體化治療指標。
Subjective and HRV‑based Data Assessing Supervising Surgeon Intraoperative Stress with Perceived Trainee Breast Surgery Skill Proficiency
Journal of surgical education
利用 HRV 與主觀量測評估外科教學情境的壓力，探討教學效益。
Multisensory dysfunction across sleep disorders: A systematic review of 31 human modalities.
Sleep medicine reviews
系統整理睡眠障礙中的感官功能障礙，特別包括 HRV 相關指標。
Noradrenergic infraslow rhythm during sleep is the critical link between heart‑rate dynamics and memory consolidation.
eLife
發現睡眠期的低頻神經訊號與記憶固化緊密相連，解釋 HRV 的功能意義。
Research on cardiovascular functioning in minority groups: From biological explanations to social and discrimination‑related determinants.
Public health in practice (Oxford, England)
探討種族與社會因素對自律神經功能的影響，提出健康差異的機制。
Preictal reduction in heart rate variability entropy is associated with functional/dissociative seizures and provides modest discrimination from epileptic seizures.
Epilepsy & behavior
HRV 熵值下降可作為功能性與癲癇性發作的分化指標，具臨床預測價值。
Heart rate variability and emotion regulation: Multiethnic differences in reappraisal and suppression.
Emotion (Washington, D.C.)
揭示不同族群在情緒調節策略下的 HRV 差異，為跨文化情緒干預提供依據。
Temporal trends in heart rate characteristic index preceding necrotizing enterocolitis in preterm infants.
Journal of neonatal‑perinatal medicine
預測壞死性腸炎發作的心率指標時間趨勢，有助於早期干預。
Evaluation of Early Diagnostic Methods for Subclinical Cardiovascular Changes in Childhood Obesity.
Medeniyet medical journal
探討兒童肥胖早期心血管變化的診斷技巧，強調 HRV 與自律神經的角色。
Presleep Whey but Not Casein Protein Ingestion Improves Sleep Quality After Resistance Exercise When Compared With an Isocaloric Control in Resistance Trained Individuals.
International journal of sport nutrition and exercise metabolism
Whey 蛋白質在睡前攝取可提升抵抗訓練者的睡眠品質，關聯 HRV 改善。
Interindividual differences in dyspnea during acute hypoxic exercise in healthy adults: A single exposure to simulated altitude at ~9000 ft.
Physiological reports
探討高度模擬下的呼吸與自律神經反應差異，涉及氧氣供應與肌肉耐力。
The cold‑water immersion recovery‑adaptation paradox: Reconciling acute parasympathetic and analgesic benefits with chronic hypertrophy attenuation.
Experimental physiology
冷水浸泡同時提升副交感活性與疼痛緩解，但長期可能抑制肌肉肥大。
Brief virtual nature exposure and acute stress: Inconclusive evidence regarding stress reactivity, recovery, and emotion regulation.
Journal of environmental psychology
虛擬自然曝光對壓力反應的影響尚不明確，需要更多 HRV 測量支持。
Autonomic and limbic system functioning, early life stress, and depressive symptoms in adolescence.
Neurobiology of stress
早期壓力與自律神經功能共同預測青少年抑鬱症狀，提供干預切入點。
The impact of technoference and the digital still‑face on socioemotional development in infants (0‑24 months): A systematic review.
Infant behavior & development
探討科技干擾對嬰兒社交發展的影響，涉及自律神經指標。
The mediating role of cardiac autonomic imbalance in the association between hypoxic burden and dyslipidemia in obstructive sleep apnea.
Annals of medicine
證實心率變異度失衡在 OSA 與代謝異常之間的中介作用，可作為治療指標。
Heart Rate Variability in Pediatric Patients with and without Sickle Cell Disease.
Progress in pediatric cardiology
比較 sickle cell 病童與健康兒童的 HRV 差異，顯示自律神經功能受影響。
Cardiovascular autonomic dysfunction in Morvan syndrome: A comparative study of heart rate variability and cardiovascular autonomic reflex tests.
Revue neurologique
Morvan 症候群患者的 HRV 明顯異常，與抗體水平相關，可作為診斷輔助。
Cardiovascular autonomic dysfunction in patients with chronic obstructive pulmonary disease.
PloS one
COPD 患者自律神經功能受損，體育活動可改善 HRV，降低心血管風險。
Heterozygous gain‑of‑function and mixed‑type Kcna2 variants recapitulate SUDEP and increased cortical Npy‑Npy1r signaling.
Neurobiology of disease
KCNA2 基因變異與突發性心臟死亡相關，探討其神經訊號機制。
Root‑associated bacterial and fungal communities of the endangered p̂|rámo bromeliad Puya goudotiana.
PloS one
探索稀有植物根部微生物群落，對生態保育有意涵義。
Theabrownin Alleviates Alcoholic Liver Disease in Mice by Improving Gut Microbiota and Tryptophan Metabolism.
Molecular nutrition & food research
Theabrownin 透過調節腸道菌相和色胺代謝降低肝損傷，提供營養療法新視角。
Combined Docosahexaenoic Acid and Captopril Treatment Attenuates Indole Acetic Acid Induced Cardiovascular Injury in Chronic Kidney Disease.
Molecular nutrition & food research
Omega‑3 與 ACE 抑制劑雙重治療可抵禦炎症介導的心血管傷害，具潛在臨床價值。
Lactobacillus Fermentum MCC2760 Mitigates Oxidized Oil‑Induced Metabolic Dysfunction and Gut‑liver Axis Perturbations: A Two‑Generation Study in Rats.
Probiotics and antimicrobial proteins
特定益生菌可抑制氧化油介導的代謝功能障礙，改善腸肝軸健康，具潛在營養干預意義。
Microbial dysbiosis exacerbates exercise fatigue in mice under hypobaric hypoxia.
Journal of applied microbiology
菌群失衡在高反 pressure 環境下加劇運動疲勞，提示微生態在耐久性中的角色。
Inhibition of Tropomyosin Receptor Kinase B Signaling Alters Hepatic Mitochondrial Enzyme Activity and Oxidative Stress in Mice With Sucrose‑Induced Insulin Resistance.
Journal of biochemical and molecular toxicology
TrkB 信號阻斷改變肝臟能能，降低胰島素抵抗相關的氧化壓力，提供代謝治療新靶點。
Detection of Pancreatic Cancer via Specific Metabolite Markers: A Metabolomics Approach.
Health science reports
利用代謝組學找出胰臟癌特異代謝標記，提升早期診斷潛力。
Elevated plasma glucagon‑like Peptide‑1 levels are associated with enteral feeding intolerance in traumatic brain injury.
Clinical nutrition (Edinburgh, Scotland)
GLP‑1 水平高低與腸外餵養不耐受相關，可作為 TBI 病患營養管理的預測指標。