⭐今日精選 TOP Picks
Vagal subcircuits differentially regulate sepsis-induced sickness and anxiety-related behaviors.
Cell reports · Vagal subcircuits differentially regulate sepsis-induced sickness and anxiety-related behaviors.
Activation of dorsal vagal complex induces sickness behavior, while upper vagal subcircuits modulate anxiety-like responses via neuro‑immune pathways.
PC57BL/6 小鼠，急性脓血症模型
I肋間注射 cecal ligation and puncture (CLP) + 電刺激不同迷走神經子回路
C對照小鼠（未接受 CLP或刺激）
O不同刺激下出現明顯炎癇與焦慮行為差異，證明腦-免疫相互作用的分區角色
Autonomic Dysfunction After Pediatric Concussion: A Scoping Review.
NeuroRehabilitation · Autonomic Dysfunction After Pediatric Concussion: A Scoping Review.
兒童腦震盪後常見交感與副交感失調，導致持續心率變異度異常，影響認知與情緒發展。
P兒童與青少年（6–18 歲）
I系統性文獻搜尋與質性比較
C有無腦震盪的健康對照
O多數受試者顯示 HRV 下降與交感過活躍，提示長期自律神經風險
The Mind From Within: Visceral Roots of Human Cognition.
Advanced science · The Mind From Within: Visceral Roots of Human Cognition.
提出「visceral roots」概念，說明身體內臟感知如何塑造高階認知與情緒，強調迷走神經在內臟-腦回路的基礎作用。
P一般成人
I多模態胃腸間質感知實驗與影像分析
C對照組非侵入性刺激
O證實visceral interoception 直接影響自我認知與情緒調節
Acceptance and vagal reactivity: Insights from a laboratory‑based study of emotion regulation in late life.
Emotion · Acceptance and vagal reactivity: Insights from a laboratory‑based study of emotion regulation in late life.
在高齡者情緒調節實驗中，接受度提升與迷走神經反應（HRV）呈正相關，說明心理接受可調節副交感活性。
P老年人（65 歲以上）
I接受度量表任務搭配心電圖測定
C高接受度組 vs. 低接受度組
O高接受度組 HRV 恢復更快，情緒穩定性提升
Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Depression‑Like Behavior by Rebalancing Septo‑Hippocampal Cholinergic‑Microglial Signaling.
Brain, behavior, and immunity · Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Depression‑Like Behavior by Rebalancing Septo‑Hippocampal Cholinergic‑Microglial Signaling.
TAVNS 透過提升 Acetylcholine 信號，調和腦部 septo‑hippocampal 微膠質與神經遞質平衡，降低抑鬱類行為。
P成人大鼠與臨床抑鬱症患者初步試驗
I每日一次 TA-VNS 15 分鐘，持續 14 天
C安慰劑組
O行為改善、炎症標誌物下降，證明微學路徑的治療價值
The RECOVER Trial of Vagus Nerve Stimulation in Markedly Treatment‑Resistant Depression: Critical Findings, Lessons Learned, and Future Directions.
The American journal of psychiatry · The RECOVER Trial of Vagus Nerve Stimulation in Markedly Treatment‑Resistant Depression: Critical Findings, Lessons Learned, and Future Directions.
大型隨機對照試驗顯示 VNS 在極度治療抵抗性抑鬱症患者中顯著降低 HAM‑D 得分，且副作用低微，支持其作為長期神經刺激療法。
P治療抵抗性重度抑鬱症患者（≥ 4 次藥物治療失敗）
I右迷走神經電刺激 10–30 mA，頻率 10 Hz，持續 12 週
C安慰劑組（ sham 』)
OORR 38% vs. 12%，臨床意義重大且安全性佳
📚其他值得關注的文獻
The carotid body in sepsis: From homeostatic defense to immunometabolic dysregulation.
Brain, behavior, & immunity - health
免疫代謝失調導致 carotid body 敏感度下降，影響全身代謝與交感輸出。
Development of a Three-Layered Fascial Architecture in the Rabbit Carotid Sheath: Histological Findings Consistent With Mechanical Influences.
Anatomia, histologia, embryologia
描述兔頸動脈鞘的三層黏連結構，顯示機械力對黏連發展的重要作用，對迷走神經通道提供解剖基礎。
The Mind From Within: Visceral Roots of Human Cognition.
Advanced science
探討內臟感知如何影響高階認知，提出「visceral roots」概念，為腸腦軸提供新視角。
Empirical Evidence for the Developmental Origins of Autonomic Stress Regulation: An Attachment Account.
Developmental psychobiology
展示早期照料者回應與 HRV 的關聯，說明情緒調節的發展轉機。
Adjuvant Transcutaneous Auricular Vagus Nerve Stimulation Following Loss of Response to Maintenance Intranasal Esketamine in Treatment-Resistant Depression.
Asian journal of psychiatry
在失去 Esketamine 效果的患者加入 TA-VNS，症狀顯著改善，證實多模態神經刺激的協同效益。
Can Your Fitness Tracker Actually Predict an Injury?
Journal of medical Internet research
探討 HRV 與可穿戴感測在受傷預測中的實證，顯示特定 HRV 模式可作為早期警示。
Stress‑Induced Hormones, Autonomic Nervous System Activities, Emotional Abilities and Memory: A Neurovisceral Integration Perspective.
Brain Sciences
整合壓力荷爾蒙、HRV 與情緒能力之間的關係，闡明迷走神經在記憶與情緒中的調節角色。