今日文獻聚焦於針灸與中草藥在精神疾病中的神經生理機制,特別是腸腦軸、MAPK/JNK通路及前額葉功能調控,顯示中醫精神醫學正從經驗應用向分子機制與神影像證據邁進,臨床轉化潛力顯著。
Neuropsychiatric disease and treatment · Acupuncture Modulation of the Microbiota-Gut-Brain Axis in Major Depressive Disorder: Integrative Mechanisms, Emerging Evidence, and Future Therapeutic Perspectives.
首次系統闡釋針灸經由調節腸黏膜屏障、微生物代謝物、免疫與神內分泌通路改善憂鬱症,提供身心醫學與腸腦軸療法的理論橋樑,具高度整合性與臨床延伸性。
Neuropharmacology · Acupuncture improves depressive symptoms and prefrontal cortical function in mild to moderate depressive disorder: A randomized sham-controlled trial and fNIRS study.
真針灸組較假針灸組顯著改善HAMD評分,並經fNIRS證實增強背外側前額葉氧合動態,首次以客觀神影像證實針灸對憂鬱症的前額葉調節效應。
Journal of ethnopharmacology · Du-Shu-Wan alleviates Tau protein phosphorylation in Alzheimer's disease by regulating MAPK/JNK signaling pathway.
杜樹丸透過抑制 MAPK/JNK 通路降低 tau 蛋白過度磷酸化,揭示其改善認知功能的分子基礎,為中藥治療失智症提供新標的。
Journal of ethnopharmacology · San Wei Tan Xiang (SWTX) ameliorates depressive-like behaviors by modulating 6-phosphogluconate dehydrogenase (6PGD) activity in mice.
三味檀香透過調節 pentose phosphate phosphate 路徑關鍵酶 6PGD 的活性,改善 corticosterone 誘導之抑鬱様行為,首次連結代謝調節與中藥抗憂鬱效應。
Pain management nursing : official journal of the American Society of Pain Management Nurses · Auricular Acupuncture in Older Women With Knee Osteoarthritis: A Randomized Clinical Trial.
每週一次耳針,連續10週,顯著減輕老年女性膝關節疼痛、改善功能能力並緩解憂鬱症狀(GDS-15),證實耳針對身心共病具多重獲益。
Annals of medicine
擬評估紅外線艾灸對血脂、腸道菌群及腦灰質體積的影響,雖僅為方案論文,但擴展了艾灸在代謝-認知雙重風險干預的探索。
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
經皮耳部迷走神經刺激(tVNS)在透析患者中主要改善透析效率及症狀,對憂鬱等精神狀況之次級分析尚待進一步報告,屬神經調控類介入。