TCM Psychiatry · 中醫精神醫學文獻日報

⭐今日精選 TOP Picks

#1 💪🧠 高實用性

Xiaoyaosan reactivates the muscle-brain axis via FNDC5/Irisin to ameliorate LPS-induced depression.

Phytomedicine : international journal of phytotherapy and phytopharmacology · Xiaoyaosan reactivates the muscle-brain axis via FNDC5/Irisin to ameliorate LPS-induced depression.

本研究揭示 Xiaoyaosan 透過激活肌肉 FNDC5/Irisin 路徑，修復肌腦軸並改善海馬突觸可塑性，從而緩解抑鬱樣行為，提供中醫抗抑鬱的具體分子機制。

PLPS誘導之抑鬱樣行為小鼠模型

IXiaoyaosan (XYS) 給予

C模型組未處理或安慰劑

O降低抑鬱樣行為，上調肌肉 FNDC5/Irisin 表達，增強海馬突觸可塑性及神經營養支持

中草藥抑鬱症腸腦軸BDNF網絡藥理學隨機對照試驗閱讀原文 →

#2 ⚖️🧠 高實用性

Treatment-related associations of nucleus accumbens connectivity within mesocorticolimbic circuits in depression.

Journal of affective disorders · Treatment-related associations of nucleus accumbens connectivity within mesocorticolimbic circuits in depression.

fluoxetine 與中醫方劑 Shugan Jieyu Capsule (SG) 均顯著改善輕中度抑鬱症狀，並伴隨伏隔核結構與功能連接性的正向變化，提示其共同神經機制。

P60 名輕中度抑鬱症患者 (MMD)

I8 週 fluoxetine 或 Shugan Jieyu Capsule (SG)

C基線 vs 8 週末

O兩組皆顯著減少 HAMD-24 評分；SG 組在伏隔核前額連結性增加與臨床改善呈正相關

中草藥抑鬱症中西整合隨機對照試驗神經發炎HPA軸閱讀原文 →

#3 😴🔬 高實用性

Jiao-tai-wan suppresses ferroptosis induced by heart-kidney disharmony insomnia by regulating the PDE4D/BDNF signaling pathway.

Phytomedicine : international journal of phytotherapy and phytopharmacology · Jiao-tai-wan suppresses ferroptosis induced by heart-kidney disharmony insomnia by regulating the PDE4D/BDNF signaling pathway.

Jiao-tai-wan 透過抑制鐵死亡並上調 PDE4D/BDNF 訊號，改善心腎不交型失眠小鼠的行為表現與海馬神經元損傷，揭示其安眠新機制。

PPCPA + MMPM 誘導之失眠小鼠模型

IJiao-tai-wan (JTW) 提取物或藥血清

C模型組 + 給藥組

O減少海馬神經元鐵死亡標誌，上調 BDNF 與減少 PDE4D，改善進食延遲潛伏期與總睡眠時間

中草藥失眠腸腦軸BDNF網絡藥理學隨機對照試驗閱讀原文 →

#4 👵📋 中實用性

Association between Traditional Chinese Medicine constitution and geriatric functional impairment evaluated by the integrated care for older people approach in the elderly.

Journal of traditional and complementary medicine · Association between Traditional Chinese Medicine constitution and geriatric functional impairment evaluated by the integrated care for older people approach in the elderly.

在老年人中，陰虛質與痰濕質體質與多項ICOPE功能障礙（特別是認知、行動與憂鬱）呈正相關，提示TCM體質辨證可作為老年功能預警工具。

P392 位平均年齡 71.94 歲之門診及長照老者

ITCM 體質分類 (CCMQ-EE)

C平和質 vs 其他體質類型

O陰虛質與痰濕質顯著增加認知障礙 (OR=2.1)、行動障礙 (OR=1.8) 與憂鬱 (OR=2.3) 風險

證候辨證老年精神醫學認知障礙抑鬱症社區精神醫學中西整合閱讀原文 →

#5 🤕🌿 中實用性

Migraine relief: Solutions from natural bioactive products of Traditional Chinese medicine.

Journal of ethnopharmacology · Migraine relief: Solutions from natural bioactive products of Traditional Chinese medicine.

系統評指出，多種TCM源生物活性產物（如川芎嗪、薄荷腦、黃酮類）經調節神經發炎、三叉神經通路與膠質細胞活化，示緩解偏頭痛之潛力，儘管多為前臨床證據。

P偏頭痛動物模型或細胞系統

ITCM 天然生物活性產物 (單一或複方)

C對照或標準藥物 (如宣敏醋酸鹽)

O減少偏頭痛行為表現，下調 CGRP、IL-1β、TNF-α 及神經活化標誌

中草藥神經發炎腸腦軸網絡藥理學中西整合系統性回顧閱讀原文 →

📚其他值得關注的文獻

🎗️🧘 中

Evidence-Based Perspectives on Complementary and Alternative Medicine in Cancer Treatment: Current Advances and Clinical Relevance.

Journal of multidisciplinary healthcare

雖未聚焦精神健康，但廣泛評論指出中醫（如針灸、太極）在癌症患者中可緩解疼痛、疲乏與焦慮，提升生活品質，具支持性證據。

中西整合針灸氣功/太極焦慮症安全性系統性回顧 PubMed →

❤️‍🩹💔 中

The common mechanism underlying Shuangxinfang's amelioration of post-myocardial infarction depression: Targeting S100A9/NLRP3 to improve mitochondrial energetics.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Shuangxinfang 透過抑制 S100A9/NLRP3 炎症小體，改善線粒體功能，從同時緩解心肌梗死後抑鬱與心臟恢復不良，揭示身心共病之共通機制。

中草藥抑鬱症神經發炎腸腦軸網絡藥理學身心醫學 PubMed →