TCM Psychiatry · 中醫精神醫學文獻日報

#1 🧠 中實用性

Modified Xiaoyao San Ameliorates Depression-Like Behaviors and Neuronal Necroptosis in a Mouse Model of Chronic Unpredictable Mild Stress.

Journal of visualized experiments : JoVE · Modified Xiaoyao San Ameliorates Depression-Like Behaviors and Neuronal Necroptosis in a Mouse Model of Chronic Unpredictable Mild Stress.

經改良的逍遙散可透過抑制神經 necroptosis 途徑改善慢性應激小鼠的抑鬱樣行為，揭示其中草藥抗抑鬱的潛在神經保護機轉。

P慢性不可預測輕度應激（CUMS）誘導抑鬱樣行為的小鼠模型

I改良逍遙散（MXYS）給予

C對照組（模型組或車輛處理組）

O抑鬱樣行為改善（如蔗糖偏好降低、 immobilisation 增加）及神經 necroptosis 相關蛋白表達下調（如 RIPK1、RIPK3、MLKL）

中草藥抑鬱症神經發炎網絡藥理學隨機對照試驗閱讀原文 →

#2 💊 中實用性

Revealing the enhancing mechanism and material basis of bile-processed Coptidis Rhizoma in anti-anxiety from perspective of cross organ regulation.

Journal of ethnopharmacology · Revealing the enhancing mechanism and material basis of bile-processed Coptidis Rhizoma in anti-anxiety from perspective of cross organ regulation.

膽汁製法顯著增強黃連素的抗焦慮效果，其機制涉及腸肝腦軸的跨器官調節，包括腸道微生物叢重塑與代謝物通路的調節。

P熱證型焦慮大鼠模型（由與壓力相關的刺激誘導）

I膽汁處理黃連 Rhizoma（BCR）給予

C未處理黃連 Rhizoma（CR）或車輛控制組

O焦慮行為顯著減少（如開場儀表盤中心區域活動增加、懸垂尾懸減少），伴隨肝代謝改善、腸道菌群結構優勢菌增加及關鍵代謝物（如膽酸、神經遞質前體）改變

中草藥焦慮症腸腦軸網絡藥理學證候辨證閱讀原文 →

#3 👆 高實用性

The Effect of Acupressure Application Before Gastrointestinal Endoscopy on Pain, Anxiety, and Nausea Symptoms: A Randomized Sham-Controlled Study.

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses · The Effect of Acupressure Application Before Gastrointestinal Endoscopy on Pain, Anxiety, and Nausea Symptoms: A Randomized Sham-Controlled Study.

內視鏡前 15 分鐘穴位壓痛（HT7、LI4、PC6）顯著降低患者疼痛、焦慮與惡心症狀，為無創、低成本的围手術期心理支持提供實證。

P準備接受胃腸內視鏡檢查的成人患者

I穴位壓壓於神門（HT7）、合谷（LI4）、內關（PC6）各 15 分鐘

C假穴位壓壓（同穴位但輕 touch 無壓力，時長 10 分鐘）

O壓痛組在程序前後的 VAS 評分中，疼痛、焦慮與惡心顯著低於假組（p < 0.05）

針灸焦慮症身心醫學隨機對照試驗社區精神醫學閱讀原文 →

TCM Psychiatry · 中醫精神醫學文獻日報

📋 今日文獻趨勢

Modified Xiaoyao San Ameliorates Depression-Like Behaviors and Neuronal Necroptosis in a Mouse Model of Chronic Unpredictable Mild Stress.

Revealing the enhancing mechanism and material basis of bile-processed Coptidis Rhizoma in anti-anxiety from perspective of cross organ regulation.

The Effect of Acupressure Application Before Gastrointestinal Endoscopy on Pain, Anxiety, and Nausea Symptoms: A Randomized Sham-Controlled Study.

Feasibility and exploratory cognitive outcomes of three exercise modalities in oldest-old adults in assisted living facilities: A 24-week pilot randomized controlled trial.