今日文獻聚焦迷幻藥物的神經機制、臨床應用及治療輔助角色,特別是憂鬱症治療及臨床試驗設計方面的突破性研究。
Journal of affective disorders · Psilocybin-assisted therapy for major depressive disorder: Perspective from meta-analysis.
標準劑量裸蓋菇素(25mg)顯著優於對照組治療重度憂鬱症,有效改善症狀、提高反應與緩解率,且效果可持續6-12週。
Neuroscience and biobehavioral reviews · Electrophysiological mechanisms of psychedelic drugs: A systematic review.
迷幻藥物對神經元興奮性、突觸傳遞和局部振盪具有複雜異質性效應,挑戰了皮層興奮性統一增加的簡化觀點。
Psychiatry research · Trip sitting or just sitting? Session facilitators substantially influence psychedelic experiences in clinical trials but not in healthy ones.
引導者對臨床參與者的迷幻體驗影響顯著(13.6%),遠高於健康志願者(0.8%),類似於傳統心理治療中治療師的效果。
The British journal of psychiatry · The Music for Subanesthetic Infusions of Ketamine randomised clinical trial: ketamine as a psychedelic treatment for highly refractory depression.
氯胺酮-心理治療方案對高度難治性憂鬱症顯著且持久的抗憂鬱效果,迷幻體驗是作用機制關鍵。
Molecules and cells · Serotonergic modulation of excitatory synapse development and plasticity.
血清素通過多種受體影響樹突棘從生成到穩定、增強和抑制的各個階段,對興奮性突觸可塑性至關重要。
Anesthesiology
探討阿片類藥物與大麻組合使用的臨床意義與風險。