生物嵌入與壓力生理 2 篇
Impact of Asymptomatic Enteroaggregative Escherichia coli Infection and Co-Pathogen Burden on Intestinal Barrier Function, Linear Growth, and Cognitive Development in Early Childhood: Insights from a Birth Cohort Study.
無症狀腸聚集性大腸桿菌感染及共同病原體負擔對幼兒腸道屏障功能、線性生長及認知發展的影響：來自出生隊列研究的見解
Lima AAM, Urtiga VLSC, Ribeiro SA, Filho JQS et al.
此出生隊列研究探討無症狀腸聚集性大腸桿菌感染對腸道屏障、線性生長及認知發展的影響。研究發現，感染與腸道通透性增加相關，進而阻礙幼兒生長並損害早期認知發展。這表明即使在無症狀情況下，環境病原體負擔也會對貧窮環境中的兒童發展產生深遠的生物嵌入效應。
Population
Birth cohort in early childhood
Intervention / Exposure
Asymptomatic Enteroaggregative E. coli infection
Comparison
No infection/Lower pathogen burden
Outcome
Intestinal barrier function, linear growth, cognitive development
- Asymptomatic E. coli infection increases intestinal permeability
- Infection is associated with impaired linear growth
- Infection negatively impacts cognitive development
Enteric infectionGrowth falteringCognitive developmentIntestinal barrier
Genetic evidence for causal effects of lifestyle factors, psychiatric factors, and socioeconomic status on various spinal disorders.
生活型態、精神因素及社會經濟地位對各種脊椎疾病因果影響的基因證據
Shao J, Xu S, Zhang H, Meng H et al.
本研究利用基因證據（孟德爾隨機化）探討社會經濟地位與生活型態對脊椎疾病的因果影響。結果顯示，低社經地位與特定脊椎疾病存在因果關聯，證實了貧困對身體健康的生物嵌入效應。這為從社會經濟層面預防肌肉骨骼疾病提供了強有力的遺傳學支持，強調改善社經狀況對生理健康的長期效益。
Population
Genetic datasets (Mendelian randomization)
Intervention / Exposure
Socioeconomic status, lifestyle, psychiatric factors
Comparison
Genetic instruments as control
Outcome
Various spinal disorders
- Socioeconomic status has a causal effect on spinal disorders
- Lifestyle factors contribute to spinal pathology
- Genetic evidence supports biological embedding of social deprivation
Socioeconomic statusSpinal disordersMendelian randomizationCausal inference
心理健康與精神病理 2 篇
Patterns of contextually sensitive adverse childhood experiences and associations with adult mental health outcomes in a longitudinal South African community sample: a latent class analysis.
南非社區樣本中情境敏感的童年不良經歷模式與成人心理健康結果的關聯：一項潛在類別分析
Thurston C, Murray AL, Franchino-Olsen H, Asghar K et al.
本研究在南非社區中運用潛在類別分析，識別出童年不良經歷的不同模式，並發現這些模式與成年後的心理健康問題顯著相關。結果顯示，特定類型的童年逆境（如家庭暴力與忽視共存）對成年心理健康具有特定的預測力，強調在心理病理評估中需考慮社會文化情境與多維度的逆境暴露。
Population
Longitudinal South African community sample
Intervention / Exposure
Patterns of adverse childhood experiences (ACEs)
Comparison
Different ACE patterns
Outcome
Adult mental health outcomes
- Distinct patterns of ACEs exist in the population
- Specific ACEs patterns predict specific mental health issues
- Contextual sensitivity is crucial in assessing ACEs
Adverse childhood experiences (ACEs)Mental healthLatent class analysisSouth Africa
Between the scales and the scars: The interpersonal moderators of the association between Body Mass Index and parent-reported depression/anxiety diagnoses in U.S. children: Evidence from the 2021-22 National Survey of Children's Health (NSCH).
體重計與傷痕之間：美國兒童BMI與父母報告的憂鬱/焦慮診斷關聯中的人際調節因素：來自2021-22年全國兒童健康調查的證據
Kajal F, Suh B, Zhao C, Ingram M et al.
本研究利用美國全國兒童健康調查數據，分析兒童BMI與父母報告的憂鬱焦慮診斷之關聯，並探討人際因素的調節作用。結果顯示，BMI對心理健康的影響受到家庭環境的顯著調節。這提示臨床在評估兒童肥胖或心理問題時，需採取生心理社會全人觀點，同時關注生理與家庭互動的影響。
Population
U.S. children (NSCH data)
Intervention / Exposure
Body Mass Index (BMI)
Comparison
Varying BMI levels
Outcome
Parent-reported depression and anxiety diagnoses
- BMI is associated with depression/anxiety diagnoses
- Interpersonal factors moderate this association
- Family environment plays a key role in the link
BMIChildhood depressionAnxietyFamily dynamics
社區與社會決定因素 4 篇
Housing Instability as a Barrier to HIV Viral Suppression: Evidence from a U.S. Systematic Review and Meta-analysis.
住房不穩定作為HIV病毒抑制的障礙：來自美國系統性回顧與元分析的證據
O'Grady T, Eisenberg M, Weinberg S, Kussainova A et al.
這項美國系統性回顧與元分析深入探討了住房不穩定對HIV病毒抑制的影響。結果顯示，住房不穩定是患者達到病毒抑制的重大障礙，顯著降低治療成功率。研究強調，在貧困或邊緣化群體中，將住房支持作為HIV護理的一部分，對改善臨床預後和控制疫情傳播至關重要。
Population
HIV positive individuals
Intervention / Exposure
Housing instability
Outcome
HIV viral suppression
- Housing instability is a major barrier to viral suppression
- Unstable housing is associated with lower treatment success
- Housing support should be integrated into HIV care
Housing instabilityHIVViral suppressionSocial determinants
Lived experiences of food insecurity in the UK: users and volunteers in community-based food aid.
英國糧食不安全的生活經驗：社區食物援助的使用者與志工
Miller S, Townsend N
本研究通過質性訪問探討英國糧食不安全者的生活經驗。結果顯示，除了食物短缺，受助者更承受著巨大的羞恥感、污名化與社交孤獨。志工同樣面臨高壓。研究指出，單靠社區慈善救濟無法根除問題，必須透過政策改革解決結構性貧困，才能消除這些貧窮帶來的心理社會傷痕。
Population
Food aid users and volunteers in the UK
Intervention / Exposure
Experience of food insecurity
Comparison
N/A (Qualitative)
Outcome
Lived experiences, stigma, psychosocial impact
- Users experience significant shame and stigma
- Volunteers are under high stress
- Charitable aid is insufficient to solve structural poverty
Food insecurityLived experienceFood aidStigma
The relationship between employment status and mental health among adults of different groups in Taiwan: a study with artistic leisure as a moderator.
台灣不同群體成年人的就業狀態與心理健康之關係：以藝術休閒為調節變量的研究
Chen CJ, Hsieh CM, Chen S, Chen A
本研究探討台灣不同族群成年人的就業狀態與心理健康關係，並分析藝術休閒的調節作用。結果發現，失業顯著損害心理健康，但參與藝術休閒活動能有效緩解此負面影響。研究建議在勞工政策與心理健康促進中，應納入藝術介入作為應對社會經濟壓力的緩衝機制，以提升民眾的心理韌性。
Population
Adults in Taiwan
Intervention / Exposure
Employment status, Artistic leisure
Comparison
Different employment statuses
Outcome
Mental health outcomes
- Unemployment negatively affects mental health
- Artistic leisure buffers the negative impact of unemployment
- Moderation effect varies across different groups
Employment statusMental healthArtistic leisureModeration
Fatal Overdose, Acute Viral Hepatitis, and HIV Attributed to Injection Drug Use, Appalachian Region of the United States, 2000-2023.
美國阿帕拉契亞地區2000-2023年歸因於注射藥物使用的致命過量、急性病毒性肝炎和HIV
Bixler D, Bennett CC, Yin S, Thomson A et al.
本研究分析美國阿帕契亞地區因注射藥物使用導致的過量致死、急性肝炎和HIV的長期趨勢。結果顯示該地區面臨嚴重的物質使用流行病，感染率上升，與社會經濟衰退密切相關。研究強調需要針對該貧困地區加強公共衛生監測與減害策略，以遏制這一由貧困驅動的健康危機。
Population
Appalachian region population
Intervention / Exposure
Injection drug use context (2000-2023)
Comparison
N/A (Trend analysis)
Outcome
Fatal overdose, Acute viral hepatitis, HIV rates
- Rising rates of overdose deaths in the region
- Increase in HIV and Hepatitis infections
- Link between socioeconomic decline and substance use crisis
Injection drug useHIVOverdoseAppalachiaPublic health