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Integrating calf circumference with nutritional and inflammatory parameters improves short-term survival prediction in outpatients with advanced cancer.
Clinical nutrition ESPEN · Integrating calf circumference with nutritional and inflammatory parameters improves short-term survival prediction in outpatients with advanced cancer.
小腿圍結合體重減輕、低白球蛋白或高C反應蛋白,可顯著提升進階癌症門診患者90日死亡率的預測力,提供簡易臨床篩檢工具。
P進階癌症門診患者 (n=370)
I小腿圍(CC)單獨或結合營養(體重減輕、食物攝入等)與發炎參數(白球蛋白、CRP、NLR)
CCC 單獨使用
O90日全因死亡率;CC+體重減輕 HR=2.83,CC+低白球蛋白 HR=3.10,CC+高CRP HR=3.20;AUC 從0.541提升至0.631
Effect of sucrose-free brazzein-sweetened ice cream on continuously monitored glycemic response in patients with metabolic dysfunction-associated steatotic liver disease: A randomized controlled double-blind crossover trial.
Clinical nutrition ESPEN · Effect of sucrose-free brazzein-sweetened ice cream on continuously monitored glycemic response in patients with metabolic dysfunction-associated steatotic liver disease: A randomized controlled double-blind crossover trial.
在代謝功能異常相關脂肪性肝病患者中,巴西zein甜ener冰淇淋相比蔗糖版本可降低餐後血糖iAUC約50%,顯示其為安全有效的糖替代選項。
P代謝功能異常相關脂肪性肝病 (MASLD) 成人 (n=101,平均年齡54.6歲,76%女性,44%併發2型糖尿病)
I巴西zein甜ener (0.014%) 或 巴西zein+菊粉 (0.014%+4g) 冰淇淋
C蔗糖甜ened冰淇淋 (14g)
O150分鐘內血糖增量曲線下面積 (iAUC):巴西zein組 31.7 vs 蔗糖組 66.3 mmol/L·min,降低52%
Geographically clustered dietary patterns associated with body mass index among nationally represented adults in Malaysia: a substitution analysis.
European journal of clinical nutrition · Geographically clustered dietary patterns associated with body mass index among nationally represented adults in Malaysia: a substitution analysis.
在馬來西亞多民族成人中,傳統飲食型態與較高BMI正相關,而將其替換為較健康飲食型態則顯著降低BMI,凸顯在地化營養干預的必要性。
P馬來西亞全國代表性成人 (n=2574,來源:MANS 2014)
I飲食型態(西型、健康型、傳統型)及其替換分析
C不同飲食型態間的等熱量替換
O傳統飲食型態與BMI正相關 (β=0.40 kg/m²),將傳統飲食替換為健康飲食則BMI下降 (β=-0.80 kg/m²)
Dietary Protein Intake, Normalized Handgrip Strength, and Gastrointestinal Symptoms in Stable Lung Transplant Recipients: A Cross-Sectional Study.
Clinical nutrition ESPEN · Dietary Protein Intake, Normalized Handgrip Strength, and Gastrointestinal Symptoms in Stable Lung Transplant Recipients: A Cross-Sectional Study.
穩定期肺移植受者若蛋白質攝入不足 (<1.0 g/kg IBW/日),則正規化握力顯著降低且胃腸症狀增加,提醒此群體需常規評估蛋白質狀態。
P移植後 ≥6個月穩定期肺移植受者 (n=78)
I蛋白質攝入量:低蛋白組 (<1.0 g/kg IBW/日) vs 足夠蛋白組 (≥1.0 g/kg IBW/日)
C兩組在正規化握力、能量攝入、胃腸症狀等的差異
O低蛋白組正規化握力較低 (15.7 vs 19.5 kg/m^0.85,p=0.019),胃腸症狀更常見 (39.5% vs 12.5%,p=0.009)
Dietary supplement practices in children with inherited metabolic disorders receiving protein-restricted diets.
Clinical nutrition ESPEN · Dietary supplement practices in children with inherited metabolic disorders receiving protein-restricted diets.
約三分之一接受天然蛋白質限制飲食的先天性代謝異常兒童使用膳食補充劑,且多由代謝專科醫師根據個體臨床需求建議,支持個體化營療而非常規補充。
P接受天然蛋白質限制飲食的先天性代謝異常 (IMDs) 兒童 (n=50)
I目前膳食補充劑使用狀況
C補充劑使用者 vs 非使用者
O目前使用補充劑 prevalence 36.0% (95% CI: 22.9–50.8);維生素-礦物質製劑最常用;高飲食依從性苯酮尿症兒童使用率更高 (50.0% vs 13.3%)
Mediterranean diet and metabolic outcomes in nafld/masld: A systematic review and meta-analysis of randomized controlled trials.
Clinical nutrition ESPEN · Mediterranean diet and metabolic outcomes in nafld/masld: A systematic review and meta-analysis of randomized controlled trials.
在地中海飲食對代謝功能異常相關脂肪性肝病的meta分析中,僅顯示BMI和甘油三酯的 modest 改善,未顯著影響胰島素抵抗或肝酵素,提醒需更嚴謹試驗澄清其療效。
P代謝功能異常相關脂肪性肝病 (NAFLD/MASLD) 患者
I地中海飲食介入
C對照飲食
OBMI SMD -0.43 (95% CI: -0.84 to -0.02, p=0.04);甘油三酯 SMD -0.50 (95% CI: -0.88 to -0.12, p=0.01);其他代謝指標無顯著差異
Impact of diabetes on muscle strength and metabolic profile in cirrhotic patients awaiting liver transplantation.
Clinical nutrition ESPEN · Impact of diabetes on muscle strength and metabolic profile in cirrhotic patients awaiting liver transplantation.
肝硬化伴糖尿病的肝移植候選者,肌肉力量顯著降低(OR 2.72),即使總能量攝入相似,提示需關注此雙重負荷群體的蛋白質品質與肌肉代謝干預。
P等待肝移植的肝硬化患者 (n=119)
I併發 hepatogenous 糖尿病 (DM)
C無糖尿病肝硬化患者
ODM組肌肉力量下降 prevalence 49.3% vs 30.4%;DM為減少手握力的獨立預測因子 (OR 2.72, 95% CI: 1.15–6.43, p=0.022)
Potassium additives in ultra-processed foods identified from food label-analysis: More than meets the eye.
Clinical nutrition ESPEN · Potassium additives in ultra-processed foods identified from food label-analysis: More than meets the eye.
在丹麥三大超市的超加工食品中,超過四分之一含鉀添加劑(如E202、E950),尤其隱藏在飲料、醬汁與海產品中,提醒慢性腎臟病患者需留意『隱形鉀』來源。
P超加工食品 (UPF,依NOVA分類)
I食品標籤分析鉀添加劑種類與分布
C不同食品類別及添加劑類型
O27.8% UPF含至少一種鉀添加劑;最常見為E202 (山梨酸鉀, 60.6%),非酒精飲料(70.9%)、醬汁(57.0%)及魚類(44.5%)為高風險類別
📚其他值得關注的文獻
Calcium, Vitamin D, and Phosphorus Levels and Bone Health in Adults with Lactose Intolerance: A Systematic Review.
Nutrition reviews
乳糖不耐受成人普遍鈣攝入不足,但血清鈣、磷與維生素D水準證據不一致,骨健康結論不明確,提醒需補充鈣而非單靠避免乳製品。
Impact of prognostic nutritional index defined malnutrition on perioperative morbidity and long-term outcomes after lung transplantation: A retrospective cohort study.
Clinical nutrition ESPEN
肺移植前營養不良(PNI<45)與較長機械通氣和住院時間相關,但未顯著影響長期生存或移植物功能,支持其作為短期風險而非長期預後指標的使用。
A LASSO-based nomogram for the risk assessment of cancer anorexia in postoperative gastric cancer patients.
Clinical nutrition ESPEN
基於LASSO的預測模型識別出11個風險變異(含教育程度、化療狀態等),並建立 nomogram 以估算術後胃癌患者癌症厭食風險(C-index 需外部驗證),提供個體化篩檢工具。
Protein intake is associated with adiposity and quality of life in adults with Becker muscular dystrophy.
Clinical nutrition ESPEN
貝克爾肌營養不良成人蛋白質攝入偏低,脂肪指數較高且生活品質降低,但無瘦質肌肉顯著差異,提示蛋白質不足可能經由代謝途徑影響身體組成與功能。
The host matters: Integrating resting energy expenditure into personalized medicine beyond tumor-centered approaches.
Clinical nutrition ESPEN
靜息能量消耗 (REE) 透過間接卡洛里測量識別高代謝為癌症惡病質的獨立預後因子,強調需將營療擴展至調節 tumour-host 代謝互動,而非仅聚焦腫瘤本身。