⭐今日精選 TOP Picks
環境敏感度與青少年飲食失調症狀之關聯：感知社會支持的調節作用研究
Journal of affective disorders · Environmental sensitivity and perceived social support in relation to adolescent eating disorder symptoms.
環境敏感度正向預測青少年飲食失調症狀，且其對社會支持的敏感度在男性中呈現性別特異性調節效應，提示環境敏感度是飲食失調發展的關鍵個體差異因子。
P466名青少年（平均年齡14.8歲，51.61%女性）
I環境敏感度（Environmental Sensitivity, ES）
C低環境敏感度組 vs 高環境敏感度組
O飲食失調症狀（ED症狀）及其與家庭、教師、同伴支持的關聯
親親過度保護、環境敏感度與青少年抑鬱症狀之中介與網絡分析：聽力正常與受損青少年的比較研究
Research in developmental disabilities · Parental overprotection, environmental sensitivity, and depressive symptoms in hearing and hearing-impaired adolescents: A mediation and network analysis.
環境敏感度透過父母過度保護間接影響青少年抑鬱症狀，且此中介路徑在聽力受損青少年中更為顯著，提示環境敏感度是親子互動與情緒問題之關鍵機制。
P2008名青少年（1386名聽力正常，622名聽力受損；平均年齡15.25歲）
I環境敏感度 (ES)
C聽力正常 vs 聽力受損青少年
O抑鬱症狀、父母過度保護、以及它們之間的中介與網絡結構
不易感與更糟：cVEDA隊列證實青少年物質使用中的差異易感性模式
Asian journal of psychiatry · For better and for worse: Evidence of differential susceptibility to environmental adversity in youth substance use from the cVEDA cohort.
家庭脆弱性放大環境逆境對青少年物質使用的影響，支持『不好也不壞』的差異易感性模式，顯示高敏感個體在正向與負向環境中皆更具可塑性。
P3786名青少年與年輕成人（12–24歲）
I環境逆境（童年逆境、不安全校園氣氛、負面親職）
C高家庭脆弱性 vs 低家庭脆弱性青少年
O物質使用風險分數（WHO ASSIST）及其基因-環境交互效應
成長因子多基因評分調節童年逆境與憂鬱症狀及治療抵抗之關聯：雙隊列影像遺傳研究
Psychiatry and clinical neurosciences · Growth factor polygenic disposition shapes associations of childhood adversity with gray matter and clinical profiles in depression: A two-cohort imaging-genetics study.
SCF/KITLG 和 HGF/MET 的多基因評分調節童年逆境對憂鬱症狀與治療抵抗的影響，並經由海馬迴和後 cingulate 迴灰白質體積中介，揭示神經生物學易感機制。
P門診憂鬱患者 (n=88) 和 UK Biobank 社會樣本 (n=226)
I童年逆境 (ACE)
C高 vs 低成長因子多基因評分 (PGS)
O憂鬱症狀嚴重程度、治療抵抗性憂鬱 (TRD)、特定腦區灰白質體積
環境敏感度在壓力反應與情緒調節中的生理基礎：福爾摩斯腦電波初步探索
Frontiers in human neuroscience · Environmental sensitivity and neural correlates of stress reactivity: A preliminary EEG study.
高環境敏感度個體在壓力任務中表現出更大的前額葉theta波活動增強，提示其情緒調節神經機制的異常敏感性，為環境敏感度的生理標誌提供初步證據。
P30名健康成人（高環境敏感度組n=15，低組n=15）
I環境敏感度 (ES) 作為分組變項
C高ES vs 低ES 群組在壓力誘發任務下的腦電波
O前額葉theta波功率變化、主觀壓力評分、皮質醇反應
📚其他值得關注的文獻
Stopping, opening, and redirecting fluid flow in paper-based microfluidic devices using thermo-responsive gelatin valves.
RSC advances
開發熱敏感膠蛋白閥門以實現紙基微流控裝置中的精確流體控制，適合低成本診斷應用。
Novel ternary covalent complexes (OsrhLF-EGCG-Mal) based on plant-derived recombinant lactoferrin (OsrhLF) by polyphenol-carbohydrate dual-modification strategy.
Food chemistry: X
透過多酚-碳水化合物雙修飾策略構建植物來源重組乳鐵蛋白複合物，增強其抗氧化與消化穩定性，具食品工業應用潛力。
Loss of transcriptional factor Zbtb33 fails to induce clonal hematopoiesis in mice but plays a role in tumor growth.
Disease models & mechanisms
Zbtb33 基因敲除小鼠造血系統正常，但會加速實體腫瘤生長，暗示其在造血介腫瘤調節中的角色。
Five-in-One NIR-II phototheranostic nanomedicine for glioblastoma multiforme: Unlocking bio-barriers and photothermal-ferroptotic amplification.
Biomaterials
開發整合五種功能的近紅外II光熱療法納米藥物，針對膠質母細胞瘤的血腦屏障穿透與協同 ferroptotic 治療。
Targeting activated hepatic stellate cells through ferroptosis: phenethyl isothiocyanate attenuates CCl-induced liver fibrosis by regulating iron metabolism, redox homeostasis, and autophagy.
Food & function
從十字花科蔬菜中提取的PEITC藉由誘導活化肝星狀細胞的鐵死亡來減輕肝纖維化，具備營養補充品發展潛力。
Role of sirtuin 7 (SIRT7) in hepatic physiology and pathophysiology: mechanism, prospective and therapeutic potential.
Biochemical pharmacology
總述SIRT7在肝臟穩態與疾病中的角色，證明其可透過調節ER壓力、脂質代謝與線粒體功能來抑制肝脂肪與纖維化，但臨床驗證仍缺。
Immunometabolic Reprogramming in the Bone Marrow Niche: Mechanisms, Plasticity, and Precision Therapeutic Targeting.
Cell biology international
闡明骨髓微環境如何透過代謝與免疫重塑來支持惡性血液細胞生存，並指出代謝重塑為介入癌症的治療標的。
Elevated asymmetric dimethylarginine drives hematopoietic stem cell metabolic reprogramming and dysfunction in chronic kidney disease.
Experimental cell research
腎臟慢性病患者血液中ADMA上升，透過激活mTOR通路損傷造血幹細胞功能，提供潛在治療標的。
Growth factor polygenic disposition shapes associations of childhood adversity with gray matter and clinical profiles in depression: A two-cohort imaging-genetics study.
Psychiatry and clinical neurosciences
SCF/KITLG 和 HGF/MET 的多基因評分調節童年逆境對憂鬱症狀與治療抵抗的影響，並經由海馬迴和後 cingulate 迴灰白質體積中介，揭示神經生物學易感機制。
Systemic delivery of phagocytosis-shielded retroviral vectors enables in vivo HSC gene therapy for sickle cell disease.
Cell stem cell
開發具吞噬保護功能的逆病毒載體，實現體內造血幹細胞基因治療於鎖鐮紅血球病，免除體外操作與住院需求。
Immunity-metabolism-senescence axis in liver fibrosis: mechanistic insights, therapeutic targets, and translational opportunities.
Clinical science (London, England : 1979)
闡述免疫、代謝與細胞 senescence 如何共同驅動肝纖維化，並指出多靶點整合療法的翻譯潛力。
Regulatory Mechanisms Within Multicellular Signaling Networks in Liver Ischemia-Reperfusion Injury: A Systematic Review Focusing on Cell-Type-Specific Interactions.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
系統性檢討肝臟缺血再灸傷期間各細胞類型間的訊號調節網路，為治療策略提供理論基礎。
Interferon-λ receptor positive monocytes/macrophages orchestrate a pro-fibrotic immune environment in hepatitis B virus-related liver fibrosis.
Clinical science (London, England : 1979)
證實IFNLR1+單核球/巨噬細胞經由調節脂質代謝促進HBV相關肝纖維化，揭示新型抗纖維化治療標的。
Enhancing the Functionality of Human Bone Marrow-Derived Mesenchymal Stromal Cells Using Signaling Modulators.
Methods in molecular biology (Clifton, N.J.)
介紹兩種功能檢定法以評估訊號調節劑對骨髓間質幹細胞造血支持能力的影響，為細胞療藥製造提供品質控制工具。
HIF-1α-ASS1 axis drives reprogramming of arginine metabolism controls hepatic stellate cell activation in hepatic fibrosis.
Phytomedicine : international journal of phytotherapy and phytopharmacology
透過HIF-1α抑制上調ASS1來恢復精氨酸代謝 homeostasis，可抑制肝星狀細胞活化與纖維化，揭示新調節軸。
FeN@C nanomaterials: Synergistic PTT/CDT/NO for the dynamic therapy of diabetic foot ulcer.
Biomaterials advances
設計鐵氮碳納米材料整合光熱、化學動態療法與一氧化氮釋放，協同治療糖尿病足潰瘍，具備抗菌與促癒合雙重功能。
PXDN knockdown alleviates hepatic stellate cell activation by regulating GPX1.
Biochimica et biophysica acta. Molecular basis of disease
Pxdn基因沉默透過上調GPX1來抑制TGF-β誘導的肝星狀細胞活化，證實PxDN-GPX1軸在肝纖維化中的調節角色。
Salvianic acid A alleviates hepatic fibrosis by inhibiting the AKT1/NF-κB axis.
European journal of pharmacology
丹參酸A透過抑制AKT1/NF-κB信號通路來減少肝纖維化與炎症，具備發展為肝病藥物的潛力。
Fibroblast activation protein-α in liver fibrosis and hepatocarcinogenesis: Stromal remodeling, molecular imaging, and theranostic targeting.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
系統性評估FAPα作為肝纖維化與肝癌連続體中之基質標的，涵蓋其生物功能、影像特徵與多樣化療法結合潛力。
E3 Ubiquitin Ligases in MASH-Associated Liver Fibrosis: Mechanisms and Therapeutic Opportunities.
Liver international : official journal of the International Association for the Study of the Liver
闡述E3泛素連接酶在代謝性脂肪性肝炎相關肝纖維化中的雙向調節角色，並討論PROTACs等新興標的策略。
Ginkgolide A alleviated liver fibrosis by modulating PI3K/AKT/NF-κB signaling to inhibit M1 macrophage polarization and macrophage-HSC crosstalk.
International immunopharmacology
銀杏內酯A透過抑制PI3K/AKT/NF-κB通路來減少巨噬細胞M1極化及其與肝星狀細胞的病態互動，從而抑制肝纖維化。
Decoding neuronal vulnerability: Multidimensional analysis of D1R- and D2R- medium-sized spiny neurons in Huntington's disease.
Brain pathology (Zurich, Switzerland)
多維度分析顯示HD中D1R-MSNs具早期代償性轉錄反應，而D2R-MSNs則更早聚積致突變蛋白，解釋其選擇性脆弱性。
CD7 CAR-T cells eliminate chronic myeloid leukemia stem cells specifically and effectively.
Hematology (Amsterdam, Netherlands)
CD7標靶的CAR-T細胞體外有效清除慢性粒細胞白血病幹細胞，並與TKI耐藥性相關，為靶向LSC提供新策略。
Decoding fibroblast activation: Transcriptional networks in hepatic stellate cells and across fibrotic organs (Review).
International journal of molecular medicine
細述肝星狀細胞轉變為 miofibroblast 的轉錄調節網路，並指出其在多器官纖維化中的共通機制，為抗纖維化療法提供轉錄層面標的。
Genome-wide characterization of heat shock protein genes reveals thermal stress-responsive candidates in Litopenaeus vannamei.
Comparative biochemistry and physiology. Part D, Genomics & proteomics
全基因組篩選白蝦HSP基因家族，識別多個熱應答候選基因（如HSPA4、HSP90AA1等），為熱適應育種提供遺傳基礎。
Notch-regulated hematopoiesis in Drosophila: Parallels and contrasts with vertebrate blood development.
Developmental biology
轉述果蠅Notch訊號如何調節造血過程，並與脊椎動物造血的保守與分異機制進行比較，強調其在血液惡性腫瘤中的調節角色。
Photophysical tuning of fluorinated benzimidazole fluorophores: Donor-acceptor systems and BSA interactions.
Bioorganic chemistry
氟化苯咪唑螢光探針（如F3Ph）透過受體-給體設計表現高環境敏感性，與牛血清白蛋白結合穩定特異，可用為微環境探針。
6-Shogaol attenuates liver fibrosis by driving hepatic stellate cell senescence through the cGAS-STING-NF-κB axis.
Phytomedicine : international journal of phytotherapy and phytopharmacology
姜黃酮透過激活cGAS-STING-NF-κB軸來誘導肝星狀細胞老化，從而抑制其活化與肝纖維化，揭示新抗纖機制。
Encapsulation of thyme essential oil: a review of mechanistic insights and emerging applications.
Food chemistry
總述百里香精油的包覆技術如何克服其揮發性與低溶解度問題，提升其作為天然防腐劑與傷口敷料的實用性。
Mechanisms of Hematopoietic Stem Cell Aging and Emerging Rejuvenation Strategies.
Stem cell reviews and reports
綜述造血幹細胞老化的分子機制（表遺傳、線粒體 dysfunction 等），並檢視針對偏myeloid細胞或表觀遺傳介入之年輕化策略潛力。
Intracellular imaging and therapeutic application of liver fibrosis via a microRNA-on self-stacking amplification circuit.
Analytica chimica acta
設計miR-on Self-Assembly Circuit (SAC) 來放大miR221-3p訊號，實現肝纖維化的活細胞成像與功能介入，經由干擾miR221-3p/SOCS1-STAT3軸達成抗纖效果。
Contribution of p38 MAPK in liver fibrosis: An overview of mechanisms, signaling pathways, and therapeutic targets (Review).
International journal of molecular medicine
系統性闡述p38 MAPK如何透過調節HSC活化、炎症與氧化應等途徑驅動肝纖維化，並指出其作為治療標的的前臨床證據與未來發展方向。
CCL28 ameliorates chronic liver damage associated with the recruitment of immunosuppressive IgA antibody-secreting cells in mice.
Life sciences
chemokine CCL28 能夠招募具免疫抑制功能的IgA+細胞進入受損肝臟，藉此減輕慢性肝損傷與纖維化，揭示新型免疫調節機制。
Uncovering molecular and functional dynamics of human hematopoietic stem cells during in vitro culture for cell therapy manufacturing.
Cytotherapy
透過單細胞分析識別ITGA3+細胞較能保持幹細胞特徵，驗證其在體外培養後仍具優秀移植潛能，為細胞療藥製造提供功能性標誌。
Morroniside ameliorates hepatic fibrosis in mice by targeting ACYP1 to promote NCOA4-mediated ferritinophagy and ferroptosis.
Phytomedicine : international journal of phytotherapy and phytopharmacology
山藥苷透過抑制ACYP1來阻斷HERC2介導的NCOA4泛素化，進而促進鐵死亡與肝星狀細胞的去活化，具備天然藥物開發潛力。
Bupleuri radix total saikosaponins alleviate liver fibrosis by inhibiting hepatic stellate cell activation via SIRT3-SMAD3/HIF-1α -mediated glycolysis.
Phytomedicine : international journal of phytotherapy and phytopharmacology
柴胡總皂苷透過抑制HIF-1α介導的糖酵解來減少肝星狀細胞活化與纖維化，證實代謝重塑為其抗纖機制之核心。
Ginsenosides alleviate the progression of hepatic fibrosis by targeting the liver circadian clock gene.
Molecular medicine reports
人參皂苷透過調節肝臟核心 circadian 基因 CLOCK 來恢復節律與減輕肝纖維化，揭示 circadian 系統在肝病中的調節角色。
Comparative phylogenomics and transcriptional regulatory networks of AQPs, HSPs, and LEA proteins in salt-stressed Portulaca oleracea.
Plant science : an international journal of experimental plant biology
整合基因組與轉錄組分析，揭露馬齒莧在鹽壓力下如何經由AQPs、HSPs與LEA蛋白的網絡調整達成鹽耐性，並提供跨物種遺傳藍圖。
Cohesin haploinsufficiency and inv(16) cooperate to reinforce Fli1 gene transcriptional programs during acute myeloid leukemia initiation and maintenance.
Leukemia
在inv(16)型急性粒細胞白血病中，cohesin亞基因半數不足與inv(16)共同強化Fli1轉錄網路，增強白血病 invasiveness 並識別Fli1為新療標的。