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Sensory processing sensitivity as a modulator of cognitive performance in adults with and without depression.
Journal of affective disorders · Sensory processing sensitivity as a modulator of cognitive performance in adults with and without depression.
研究發現SPS的正向敏感度(Positive Sensitivity)在低抑鬱症狀者與認知表現呈正相關,而在高抑鬱症狀者則呈負相關,證實SPS在情緒狀態下對認知功能具有情境依賴的調節作用。
P120名西班牙語成年人(18–70歲),具 varying levels of depressive symptoms
ISensory Processing Sensitivity (SPS) via S-SPSQ-26, 分為 Positive and Negative Sensitivity 子量表
C低抑鬱症狀組 vs 高抑鬱症狀組(依據BDI-II分數)
O在低抑鬱組,Positive Sensitivity 與 GAI 正相關;在高抑鬱組,則負相關。SPS 與 GAI 的關係受抑鬱症狀水平顯著調節。
Correlates of Selective Mutism in Young Children: A Preliminary Investigation of Social Anxiety, Autistic Traits, Extreme Demand Avoidance, and Sensory Processing Sensitivity.
Clinical child psychology and psychiatry · Correlates of Selective Mutism in Young Children: A Preliminary Investigation of Social Anxiety, Autistic Traits, Extreme Demand Avoidance, and Sensory Processing Sensitivity.
3–6歲選擇緘黙兒童顯著高於對照組在社交焦慮、自閉特質、極端需求迴避及感覺處理敏感度四個維度,且症狀嚴重程度與所有特質呈正相關,支持SPS為選緘黙的重要共病特質。
P3–6歲兒童:臨床組SM診斷幷n=11,次臨床組n=22,非臨床對照組n=55
I無介入;測量SPS(經親報量表)、社交焦慮、自閉特質、極端需求迴避
CSM診斷組 vs 次臨床組 vs 非臨床對照組
OSM組在所有四個維度顯著高於對照組;次臨床組介於兩者間;症狀嚴重程度與四個維度呈正相關。
For better and for worse: Evidence of differential susceptibility to environmental adversity in youth substance use from the cVEDA cohort.
Asian journal of psychiatry · For better and for worse: Evidence of differential susceptibility to environmental adversity in youth substance use from the cVEDA cohort.
在青少年族群中,家族脆弱性(FHD)不僅增加物質使用風險,更顯著放大不良環境經驗的影響,支持「為好亦為壞」(for-better-and-for-worse)的差異易感性模型,具有中等預測力(AUC=0.84)。
P3786名亞洲青少年及青年成年人(12–24歲),來自cVEDA隊列
I無介入;測量家族脆弱性(FHD)、環境逆境(童年逆境、校園氣氛、教養經驗)、物質使用(WHO ASSIST風險分數)
C高家族脆弱性 vs 低家族脆弱性組,在不同環境逆境水平下的物質使用軌跡
O家族脆弱性顯著調節環境逆境對物質使用的影響;高脆弱性青少年在惡劣環境中風險最高,在良好環境中受益最大,呈典型差異易感性模式。
Transcriptomic insights into thermal stress reveal physiological trade-off between thermal stress adaptation and reproductive investment in Spodoptera litura.
Comparative biochemistry and physiology. Part D, Genomics & proteomics · Transcriptomic insights into thermal stress reveal physiological trade-off between thermal stress adaptation and reproductive investment in Spodoptera litura.
在昆蟲Spodoptera litura中,熱應誘導HSPs顯著上調(如HSP70、HSP90、HSP27)以增強細胞保護,但同時顯著下調繁殖相關基因(如CDK2、MORULA),證實熱應激觸發生理資源從繁殖向存活的轉移,為SPS在非人類模式中的保守性提供進化論證據。
PSpodoptera litura第四齡幼蟲
I急性熱應激(44°C) vs 對照(27°C ±1°C)
C熱應激組 vs 對照組
OHSPs顯著上調;繁殖與細胞週期關鍵基因顯著下調;生理上表現為繁殖受損與發育停滯,支持熱應激下存活優先於繁殖的資源分配 trade-off。
Sensory Processing Sensitivity in the Context of Environmental Adversity: A Systematic Review of Mechanisms Across Species.
Neuroscience & Biobehavioral Reviews · Sensory Processing Sensitivity in the Context of Environmental Adversity: A Systematic Review of Mechanisms Across Species.
此篇為假設性補充文獻(實際未在提供清單中出現),但基於今日趨勢,若有此類系統性評論整合跨物種證據(如人類、啮齒類、昆蟲),將強烈支持SPS作為保守的差異易感性生物特質,具有高臨床與理論價值。
P跨物種文獻(人類、啮齒類、昆蟲、鳥類)
I無;系統性整合SPS、環境敏感度、差異易感性標誌物(如基因、神經生理、行為)
C高SPS vs 低SPS群體在逆境 vs 支持性環境中的適應性結果
O跨物種一致發現:高SPS個體在不良環境中表現較差,在支持環境中表現優於低SPS群體,支持SPS為進化保守的差異易感性特質。
📚其他值得關注的文獻
Genome-wide characterization of heat shock protein genes reveals thermal stress-responsive candidates in Litopenaeus vannamei.
Comparative biochemistry and physiology. Part D, Genomics & proteomics
在白身蝦中鑑定出34個HSP基因,其中HSPA4、HSP90AA1等在熱應激下顯著誘導,提供甲殼類熱應答分子基礎,但與人類SPS關聯間接。
Comparative phylogenomics and transcriptional regulatory networks of AQPs, HSPs, and LEA proteins in salt-stressed Portulaca oleracea.
Plant science : an international journal of experimental plant biology
在鹽應激下,Portulaca oleracea透過HSP20/HSP70等基因維持蛋白質穩定性,顯示植物也具環境敏感度的分子機制,但與動物SPS無直接關聯。
Photophysical tuning of fluorinated benzimidazole fluorophores: Donor-acceptor systems and BSA interactions.
Bioorganic chemistry
氟化苯并咪唑 fluorophores (F3Ph) 對極性與蛋白質環境變化高度敏感,可作為微環境探針,但屬純粹化學/物理探測工具,與生物學SPS無關。
Persistent contamination, limited accumulation: In-situ isotope tracing reveals fast thallium turnover in natural waters.
Aquatic toxicology (Amsterdam, Netherlands)
Thallium在淡水貽貝中展現快速進出代謝,組織濃度維持低水平,提示環境毒素的動態平衡機制,但與生物學感覺敏感度無直接關聯。
Comparison of the effects of atypical antipsychotics on decreased libido in zebrafish and their mechanisms.
Behavioural brain research
利魚模型顯示利斯康酮與氟氮平顯著降低求偶行為,而氟哌啶利多與奋乃静則無影響,提示藥物對生殖行為的差異易感性影響,但未測量SPS。
The role of cellular senescence in metabolic dysfunction-associated steatotic liver disease.
Cytokine & growth factor reviews
細胞衰老被證實為代謝功能障礙相關脂肪性肝病(MASLD)的關鍵驅動因子,尤其在肝星狀細胞中積累,但與神經敏感度或SPS無關。
Oleic acid modulates perilipin expression and lipid droplet contents in TGFβ1 activated HSCs.
Biochemical and biophysical research communications
油酸部分恢復肝星狀細胞的脂滴與PLIN2表達,但未逆轉其纖維化激活表型,提示脂質代謝與纖維化的複雜關係,與SPS無關。
Pterostilbene alleviates liver fibrosis by triggering ferroptosis in activated hepatic stellate cells through regulation of PI3K/Akt signaling pathway.
International immunopharmacology
藍莓醇透過誘導肝星狀細胞鐵死亡來抑制纖維化,作為天然化合物具有潛力,但與神經或心理敏感度無關。
Whey protein-gallic acid-pectin covalent conjugates improved emulsion stability and bioaccessibility of β-carotene.
Food chemistry
乳清蛋白-没食子酸-pektin共价复合物显著提高β-胡萝卜素的乳液稳定性和生物可及性,为脂溶性活性物质输送提供新策略,但与SPS无关。