📚其他值得關注的文獻
Mast Cell Derived Histamine Negatively Regulates Hematopoiesis.
Experimental hematology
調節造血幹細胞活性的新機制：肥大細胞分泌組胺透過H1受體抑制造血，抗組胺藥物西替利嗪可促進造血再生。
Salvianic acid A alleviates hepatic fibrosis by inhibiting the AKT1/NF-κB axis.
European journal of pharmacology
丹參酸A透過抑制AKT1/NF-κB信號通路減少肝星狀細胞活化，抗纖維化作用明確。
Circular RNA Fgfr2 suppresses hepatic fibrosis through the miR-1941-5p/DDAH1 axis and modulates oxidative stress- and autophagy-related signaling.
International journal of biological macromolecules
環狀RNA circFgfr2作為競爭性內源RNA，透過miR-1941-5p/DDAH1軸減少氧化應力與自噬異常，抑制肝纖維化。
LASS2 alleviates liver fibrosis by interacting with THBS1, TFRC, and APOE to inhibit TGF-β1 signaling and ferroptosis, and by reshaping the hepatocyte lipid secretome to suppress paracrine HSC activation.
Cellular signalling
LASS2透過調節脂質代謝與鐵死亡，雙重抑制肝星狀細胞活化與纖維化，為新興治療標的。
Fibroblast activation protein-α in liver fibrosis and hepatocarcinogenesis: Stromal remodeling, molecular imaging, and theranostic targeting.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
FAPα為肝纖維化與肝癌的關鍵 Stromal 標的，具影像診斷與藥物導向潛力，適合癌前篩查與介入。
MitoDAN: A Mitochondria-Targeted Cationic Fluorophore for Sensing of Polarity and Molecular Crowding in Living Cells.
ACS sensors
MitoDAN為線粒體特異性螢光探針，可同時偵測局部極性與分子擁擠度，應用於氧化應激與感染誘導的細胞重塑研究。
Transcriptomics reveals the gene expression dynamics during embryonic development of largemouth bass (Micropterus nigricans) at the endogenous nutrition stage.
Comparative biochemistry and physiology. Part D, Genomics & proteomics
大口黑鱼胚胎發育關鍵轉錄組變描述：從細胞增殖到器官形成，視覺功能與代謝轉型為內源營養階段核心特徵。
Matrix stiffness shapes early transcriptional trajectories during hepatic stellate cell activation.
Hepatology international
基質剛度透過YAP介導的機械轉導，決定肝星狀細胞是走向再生還是纖維化，軟基質促進靜止狀態，硬基質驅動纖維化程序。
Salvianolic Acid C Protects Against Hepatic Ischemia-Reperfusion Injury via Heat Shock Protein 90α-Mediated Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathway.
Phytotherapy research : PTR
丹參酸C透過HSP90α激活PI3K/AKT通路，減少肝缺血再損傷中的氧化應力、發炎與凋亡，具臨床轉化潛力。
Fibroblast stress responses to 3D-spheroid culture and thermal challenge, and stem-cell secretome-mediated repair: an exploratory in vitro investigation.
Odontology
手動聚集法誘導的3D成纖維細胞球體顯示較高HSP70表達及熱應激反應，幹細胞分泌物顯著促進成纖維細胞增殖與傷口閉合。
Biomimetic hybrid nanoparticles from grape-derived exosome-like particles and liposomes potentiate JQ1-mediated anti-fibrotic effects in hepatic stellate cells.
Journal of pharmaceutical sciences
葡萄源外泌體類似顆粒與脂質體混合奈米平台強化JQ1輸送，有效抑制肝星狀細胞活化與纖維化，為植物源奈米藥物提供新策略。
Hematopoietic Stem Cell Metabolism during Stress and Aging.
Advances in geriatric medicine and research
造血幹細胞在壓力與老化過程中的代謝重塑是其功能衰退的核心機制，糖酵解、線粒體與溶酶體功能變化共同導致造血系統下降。
E3 Ubiquitin Ligases in MASH-Associated Liver Fibrosis: Mechanisms and Therapeutic Opportunities.
Liver international : official journal of the International Association for the Study of the Liver
E3泛素連接酶在MASH相關肝纖維化中同時具促進與抑制作用，依底物與細胞類型而異，為精準醫療提供新標的。
GAA engineered to improve cellular uptake enhances correction in a preclinical hematopoietic stem cell gene therapy model of Pompe disease.
Molecular therapy. Advances
經胰島素樣生長因子2結合域標籤工程的GAA酶，經造血幹細胞基因療法遞送後，顯著改善龐佩病模型中的糖原積存與神經肌肉表型。
CD7 CAR-T cells eliminate chronic myeloid leukemia stem cells specifically and effectively.
Hematology (Amsterdam, Netherlands)
CD7 CAR-T細胞能特異性消除慢性髓性白血病幹細胞，克服TKI耐藥性，為無法根治的CML提供新策略。
Intrahepatic Platelets Orchestrate Microenvironmental Remodelling and Cellular Crosstalk in Liver Fibrosis.
Liver international : official journal of the International Association for the Study of the Liver
肝內血小板透過TGF-β1、PDGF-BB與CXCL4等介質，在肝星狀細胞、 Kupffer細胞與肝竇內皮細胞間建構促纖維化的自我強化網路，循環血小板計數無法反映局部fibrotic activity。
Decoding fibroblast activation: Transcriptional networks in hepatic stellate cells and across fibrotic organs (Review).
International journal of molecular medicine
肝星狀細胞轉變為纖維細胞的轉錄網路受炎症、代謝與機械訊號整合調節，跨器官共享機制揭示抗纖維化新標的。
Genome-wide characterization of heat shock protein genes reveals thermal stress-responsive candidates in Litopenaeus vannamei.
Comparative biochemistry and physiology. Part D, Genomics & proteomics
對白蝦進行全基因組HSP基因篩選，發現HSPA4、HSP90AA1等基因在熱應誘導下顯著上調，為熱適應育種提供分子標靶。
Hepatic stellate cell subpopulations in human MASLD-related hepatocellular carcinoma upregulate YAP via geranylgeranyl pyrophosphate.
Hepatology communications
在MASLD相關肝癌中，特定肝星狀細胞亞族透過mevalonate途徑降低GGPP，導致YAP細胞質滯留與抗癌效應，他汀類藥物或可經此路徑抑制腫瘤。
6-Shogaol attenuates liver fibrosis by driving hepatic stellate cell senescence through the cGAS-STING-NF-κB axis.
Phytomedicine : international journal of phytotherapy and phytopharmacology
薑中的6-Shogaol透過誘發肝星狀細胞老化並激活cGAS-STING-NF-κB軸，達成抗纖維化效應，提供天然化合物新策略。
Tgfbr3 is required for the long-term maintenance of self-renewal potential in murine hematopoietic stem cells.
Blood science (Baltimore, Md.)
造血幹細胞長期自我更新依賴TGF-β受體複合物Tgfbr2/Tgfbr3/Eng，而非經典的Tgfbr1/Tgfbr2，揭示幹細胞特異的訊號傳遞機制。
Intracellular imaging and therapeutic application of liver fibrosis via a microRNA-on self-stacking amplification circuit.
Analytica chimica acta
設計miR-on Self-Assembly Cascade (SAC)系統，對miR221-3p進行高靈敏度成像並藉由破壞SOCS1/STAT3軸抑制肝星狀細胞活化，達到診斷與治療雙重功能。
Contribution of p38 MAPK in liver fibrosis: An overview of mechanisms, signaling pathways, and therapeutic targets (Review).
International journal of molecular medicine
p38 MAPK是肝纖維化的核心調節器，參與HSC活化、ECM重塑、氧化應激與凋亡，其異構體特異性抑制劑為未來藥物開發關鍵。
CCL28 ameliorates chronic liver damage associated with the recruitment of immunosuppressive IgA antibody-secreting cells in mice.
Life sciences
趨化因子CCL28促進免疫抑制性IgA分泌細胞招募至肝組織，藉由IL-10與FasL介導保護作用，減輕CCl4-induced慢性肝損傷與纖維化。
Uncovering molecular and functional dynamics of human hematopoietic stem cells during in vitro culture for cell therapy manufacturing.
Cytotherapy
ITGA3與CD49f雙標記策略優於傳統CD38，能更真實反映體外培養期間造血幹細胞的幹細胞特性，為基因療法產品品質控制提供關鍵工具。
Morroniside ameliorates hepatic fibrosis in mice by targeting ACYP1 to promote NCOA4-mediated ferritinophagy and ferroptosis.
Phytomedicine : international journal of phytotherapy and phytopharmacology
茱萸苷透過抑制ACYP1促進NCOA4介導的鐵蛋白雙食與鐵死亡，精準抑制肝星狀細胞纖維化活化，為天然藥物提供新機制。
Bupleuri radix total saikosaponins alleviate liver fibrosis by inhibiting hepatic stellate cell activation via SIRT3-SMAD3/HIF-1α-mediated glycolysis.
Phytomedicine : international journal of phytotherapy and phytopharmacology
柴胡總皂苷透過SIRT3脫乙酰酶抑制HIF-1α誘導的糖酵解，間接減少肝星狀細胞活化與纖維化，驗證代謝重塑在抗纖維化中的關鍵角色。
Computational modeling of substrate-dependent lung mitochondrial respiration and bioenergetics in rats with different susceptibility to hyperoxia-induced ARDS.
American journal of physiology. Cell physiology
建構熱力學約束的肺粒線體生物能量模型，揭示高氧敏感大鼠線粒體在ANT、CIV、CI等複合體活性降低，導致ARDS中能量崩解，耐受組則經由複合體I與II維持穩定。
Epigenetic regulation in liver fibrosis: Focus on the chromatin accessibility landscape.
European journal of pharmacology
染色質可及性作為肝纖維化的表觀遺傳核心調節層，透過組蛋白修飾、ATP依賴型重塑與DNA甲基化動態控制HSC活化與ECM沉積，為精準藥物開發提供理論基礎。
Ginsenosides alleviate the progression of hepatic fibrosis by targeting the liver circadian clock gene.
Molecular medicine reports
人參皂苷透過調節肝臟核心時鐘基因CLOCK，逆轉昼夜節律亂進，抑制肝纖維化進展，顯示節律醫學在纖維病中的潛力。
The m6A reader IGF2BP2 promotes hepatic fibrosis by stabilizing AEBP1 mRNA and regulating GRB2-mediated hepatic stellate cell activation.
Biochimica et biophysica acta. Molecular basis of disease
m6A閱讀蛋白IGF2BP2穩定AEBP1 mRNA，進而活化GRB2促進肝星狀細胞活化與纖維化，揭示RNA甲基化在肝病中的新角色。
Persistent contamination, limited accumulation: In-situ isotope tracing reveals fast thallium turnover in natural waters.
Aquatic toxicology (Amsterdam, Netherlands)
雖環境中銥離子濃度超標，但淡水雙殼類 Corbicula fluminea 內部銥負荷僅略高於背景值，原因為體內排泄速率遠高於攝取，顯示場境毒動力學與實驗室差異甚大。
Transcriptomic insights into thermal stress reveal physiological trade-off between thermal stress adaptation and reproductive investment in Spodoptera litura.
Comparative biochemistry and physiology. Part D, Genomics & proteomics
斑夜蛾幼蟲在熱應激下優先啟動HSP等保護機制，同時抑制生殖與細胞週期相關基因，證明「求生優先於繁殖」的生理trade-off。
Modern approaches to gut microbiome investigation: Sequencing, culturomics, metabolomics, and beyond.
Journal of microbiological methods
腸道微生物群研究現已融合測序、培養學、代謝組與多組織技術，並擴展至單細胞基因組、空間轉錄組與晶片上微生物等創新平台，為個人化醫療奠基。
Transcriptomic analysis identifies key genes and mechanisms involved in dibutyl phthalate-induced alteration in hepatic stellate cells.
Toxicology in vitro : an international journal published in association with BIBRA
鄰苯二甲酸二丁酯（DBP）經由內質網應力、自噬、凋亡與鈣訊號通路的協同激活，嚴重破壞肝星狀細胞轉錄穩定性，為鄰苯類致肝毒性提供分子機制。
Targeting PNPLA3 I148M variant in MASLD: Cell-type specific mechanisms and precision therapy opportunities.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
PNPLA3 I148M變異是代謝功能異常相關脂肪性肝病的主要遺傳風險，其在肝細胞與肝星狀細胞中促進脂毒性、線粒體功能障礙與鐵死亡，為精準介入提供明確分子基礎。
Gene editing of hematopoietic stem cells: applications and advances.
International journal of hematology
CRISPR/Cas9等基因編輯技術克服傳統方法特異性不足的問題，使造血幹細胞體外修飾後自體回輸成為遺傳性血液疾病的臨床可行策略。
Comparison of the effects of atypical antipsychotics on decreased libido in zebrafish and their mechanisms.
Behavioural brain research
利培酮與氮氮平明顯減少斑馬魚求偶行為，機制涉及Kiss2下調、 prolactin 上升與單胺受體異常，而阿立哌唑與喘硝酮則透過神經激素合成維持生殖驅動。
Thermal stress-induced cell death pathways in Drosophila: molecular insights into apoptosis, necrosis, and autophagy.
Insect biochemistry and molecular biology
果蠅幼蟲在熱應激下主要經由Hsp過度表達啟動自噬，而在冷應激下則活化凋亡基因；嚴重熱傷導致壞死與黑斑形成，揭示壞死為熱性死亡的主要被忽視驅動因子。
Potentially regulating the ApoB RNA editosome via FXR activation: The natural compound continentalic acid alleviates hepatic fibrogenesis.
Phytomedicine : international journal of phytotherapy and phytopharmacology
大陸綬藥鹼透過活化FXR抑制Apobec1/A1CF編輯體，減少肝星狀細胞活化與ECM沉積，驗證FXR在肝纖維化中的調節角色。
Developmental Control of DNA Damage Responses in α- and β-Cells Shapes the Selective β-Cell Susceptibility in Diabetes.
Diabetes
胰島β細胞對DNA損傷的較高敏感性來源於發育時期的表觀基因組程式，而非成年後的代謝壓力，α細胞則經較快更新規避 senescence。
Disruption of methionine metabolism drives erythroid cell fate reprogramming by remodeling the H3K4me3 landscape.
The Journal of clinical investigation
同型半胱氨酸水解酶（AHCY）缺損導致紅細胞生成程式重設，促進造血幹細胞與免疫細胞分化，揭示代謝-表觀遺傳軸在細胞命運決策中的核心角色。
Antioxidant efficiency is associated with differential susceptibility to oxidative damage and senescence progression in dermal and lung fibroblasts exposed to occupationally relevant glyphosate concentrations.
Environmental toxicology and pharmacology
草甘膦暴露降低非蛋白抗氧化能力並升氧化應標誌，加速真皮與肺成纖維細胞 senescence，提示抗氧化能力個體差異可能為其敏感性關鍵。
Liver fibrosis: Pathogenesis and innovative nanoparticle-based therapeutic strategies.
International journal of pharmaceutics: X
納米藥物傳遞系統（如脂質體、微晶）經由精準靶向肝星狀細胞，提升抗纖織療效同時降低離目標效應，為肝病治療帶來轉變機會。
Oleic acid modulates perilipin expression and lipid droplet contents in TGF-β1 activated HSCs.
Biochemical and biophysical research communications
油酸部分恢復肝星狀細胞脂質滴pletin2表達，但無法顯著逆轉纖維化標誌，提示脂質滴pletin重塑是代謝適應而非致病驅動。
Pterostilbene alleviates liver fibrosis by triggering ferroptosis in activated hepatic stellate cells through regulation of PI3K/Akt signaling pathway.
International immunopharmacology
藍莓與葡萄中的鐵閃土壘素透過抑制PI3K/Akt誘導肝星狀細胞鐵死亡，達成抗纖維化效應，證明代謝重塑是其核心機制。
Discovery of cis-Gnetin H from peony seed coat as a potent antifibrotic agent modulating hepatic fibro-inflammatory pathways and gut microbiota homeostasis.
Phytomedicine : international journal of phytotherapy and phytopharmacology
牡丹種衣分離出的cis-Gnetin H顯著抑制肝星狀細胞活化，透過Nrf2/HO-1抗氧化途徑與腸-肝軸微生物重塑（增加SCFA、減少致病菌）達成抗纖維化，為天然藥物提供雙重作用機制。
Whey protein-gallic acid-pectin covalent conjugates improved emulsion stability and bioaccessibility of β-carotene.
Food chemistry
乳청蛋餰-没食子酸-果膠共价偶联物显著提高β-胡萝卜素乳液的稳定性与生物可及性，其中三元共价偶联物封装效率最高（96.25%），为脂溶性活性物质输送提供新策略。
Interplay between growth factor signaling and epigenetic landscapes in stem cell stemness.
Cytokine
生長因子與細胞因子訊號透過染色質重塑、DNA甲基化與組蛋白修飾等表觀遺傳途徑調控幹細胞自我更新與分化，為再生醫療提供分子基礎。
Patterns and correlates of unlicensed cannabis cultivation in California (USA) following adult-use legalization.
The International journal on drug policy
大麻合法化後，加州未許可種植呈現空間聚集，受地形、建築密度與執法強度影響，而合法農場的存在是減少非法種植的最強預測因子，顯示參與性監管可同時穩定市場與減少生態影響。