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Recent literature shows expanding research on hepatic fibrosis mechanisms, environmental toxicants, stress responses, and plant-derived antifibrotic compounds, with growing interest in molecular pathways and targeted therapies.
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容器蛋白ALR缺乏导致肝纤维化恶化，与MICU1/2异二聚化减少及HSC线粒体钙离子失调有关
Free radical biology & medicine · Deterioration of liver fibrosis by ALR deficiency is associated with reducing MICU1/2 heterodimerization and mitochondrial calcium dysbalance in hepatic stellate cells.
肝纤维化进展与ALR缺乏相关，影响MICU1/2异二聚化导致HSC线粒体钙离子失调，阐明新的治疗靶点。
P肝纤维化小鼠及患者肝组织
IALR基因敲除或敲低
C对照组（正常ALR表达）
O肝纤维化程度加重，HSC激活增加
三萜醇通过HSD11B1-ERK MAPK轴抑制肝星状细胞激活
Acta biochimica et biophysica Sinica · Taraxasterol alleviates liver fibrosis by suppressing hepatic stellate cell activation via the HSD11B1-ERK MAPK signaling axis.
三萜醇靶向HSD11B1抑制ERK MAPK通路，有效逆转肝纤维化小鼠模型中的肝星状细胞激活。
PCCl₄和DDC诱导的肝纤维化小鼠模型
I三萜醇药物治疗
C未接受治疗的纤维化对照组
O肝纤维化显著减轻，肝星状细胞激活下降
天然化合物绿原酸激活FXR抑制肝纤维化通路
Phytomedicine : international journal of phytotherapy and phytopharmacology · Continentalic acid ameliorates hepatic fibrosis by targeting FXR and Apobec1/A1CF.
Continentalic酸通过激活FXR抑制Apobec1/A1CF表达，从而阻断肝纤维化进程。
PTAA诱导肝纤维化小鼠模型
IContinentalic酸或FXR激动剂治疗
C对照组与FXR敲低组
O肝纤维化减轻，炎症与胶原沉积下降
热应激诱导小鼠骨骼肌自噬通量增加，但不降低自噬蛋白表达
American journal of physiology. Regulatory, integrative and comparative physiology · Prolonged heat stress induces autophagy in mouse skeletal muscle.
热应激提升骨骼肌自噬通量，特别在快速肌肉（胫骨肌、横膈膜）中表现显著，暗示应激下的代谢适应。
P热应激小鼠骨骼肌组织
I高温暴露（37.5℃, 24小时）
C常温对照组
O自噬通量上调，HSP表达不变
微塑料污染改变海洋微型生物群落的敏感度与功能连接性
Environmental science & technology · Microplastic Pollution Is Associated with Fragmentation and Environmental Sensitivity of Marine Planktonic Microbial Communities.
微塑料污染导致海洋微生物社群功能连接碎片化，增加对环境驱动的敏感度，削弱生态韧性。
P全球海洋微塑料污染环境
I不同微塑料浓度梯度
C低微塑料 vs. 高微塑料环境
O微生物敏感性增加，连接性降低
Senescence-associated secretory phenotype in microglia drives cognitive decline and neuroinflammation in aged mice
Nature Aging · Microglial senescence-associated secretory phenotype drives cognitive decline and neuroinflammation in aged mice.
老年小胶质细胞分泌表型促进认知衰退和神经炎症，为干预衰老相关神经疾病提供新靶点。
P老年小鼠脑组织与认知行为检测
I清除小胶质细胞或抑制SASP
C正常老化对照组
O认知功能减退，炎症标志物上调
ELF5调控肝星状细胞运化与肝纤维化进程
Hepatology · ELF5 regulates hepatic stellate cell transdifferentiation and liver fibrosis progression.
ELF5表达上调促进HSC运化为纤维化细胞，敲除ELF5可抑制肝纤维化进展。
P人类与小鼠肝纤维化组织
IELF5敲除或过表达
CWT肝组织
OHSC运化程度与纤维化程度正相关
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Morroniside ameliorates hepatic fibrosis in mice by targeting ACYP1 to promote NCOA4-mediated ferritinophagy and ferroptosis.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Morroniside通过抑制ACYP1介导的铁死亡抑制肝纤维化，揭示新的分子机制。
From dormancy to germination: Transcriptome analysis reveals the potential involvement of heat shock proteins in gibberellin-induced seed dormancy release in Solanum torvum.
Genomics
热湿处理诱导Solanum torvum种子萌发，HSP基因表达动态变化可能与休眠解除有关。
Functional restoration of immune defects in STAT1 gain-of-function disease following stem cell gene editing.
Blood
基因编辑修复STAT1 GOF突变，恢复免疫功能，为免疫缺陷疾病提供基因疗法新策略。
Functional restoration of immune defects in STAT1 gain-of-function disease following stem cell gene editing.
Blood
基因编辑修复STAT1 GOF突变，恢复免疫功能，为免疫缺陷疾病提供基因疗法新策略。
Adaptive response to long-term high temperatures during the reproductive development in Arabidopsis thaliana.
Planta
长期高温下调调控开花与生殖的基因，热休眠相关蛋白关键性凸显。
Valorization of Ficus carica Pruning Residues as Selective Botanical Insecticides: Optimized Furanocoumarin Extraction, Efficacy Against Neotropical Stink Bugs, and Mechanistic Insights via Molecular Docking.
Archives of insect biochemistry and physiology
从无花果修剪残渣提取多酚类驱虫成分，展示对特定害虫的选择性作用与机制。
SPG4 Hereditary Spastic Paraplegia: From Etiology to Therapy.
Movement disorders : official journal of the Movement Disorder Society
SPG4型遗传性脊髓性肌萎缩症的致病基因与潜在疗法综述。
Resolving hematopoietic stem versus progenitor cell potential in the mouse dorsal aorta by differential Runx1 +110 enhancer activity.
Cell reports
RUNX1增强子活性区分HSC与HPC潜能，为造血干细胞研究提供精准标记工具。
Examining relationships between sensory processing sensitivity (SPS), physical activity context preferences, and physical activity self-efficacy in undergraduate students.
Journal of American college health : J of ACH
高感知性（SPS）与学生的运动环境偏好及自信心呈负相关，提供干预建议。
The functional relevance of human leukocyte antigens in the development of cord blood derived advanced cellular therapies: A new direction of public cord blood banks.
Human immunology
系统分析公共脐带血库的HLA分型特征，为ATMP研发提供参考。
Natural small molecule evodiamine alleviates liver fibrosis by targeting the ANXA2-p110α axis in hepatic stellate cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Evodiamine抑制ANXA2-p110α通路，减轻肝纤维化，展示植物药物的多靶点作用。
Altered theta-band sensory gating in individuals with high sensory processing sensitivity (SPS).
Brain research
高SPS个体在θ波段感官门控表现出更强抑制，提供神经生理依据。
Pien-Tze-Huang inhibits colorectal cancer liver metastasis in mice by modulating immunosuppressive and fibrotic microenvironments.
Translational research : the journal of laboratory and clinical medicine
千金片抑制肿瘤肝转移，调节巨噬细胞与肝星状细胞的互作，前景可期。
G22037, a novel oxadiazole-pyrazole derivative, attenuates liver fibrosis by targeting annexin A5 and inhibition of ER stress-dependent hepatic stellate cell activation.
Biochemical pharmacology
G22037通过抑制ANXA5和ER应激阻止HSC激活，展示新型小分子抗纤维化潜力。
MicroRNA-200c regulates hepatic stellate cell activation via TGF-β/Smad signaling.
Journal of Hepatology
miR-200c抑制HSC的活化，减缓肝纤维化进程，提供RNA治疗新靶点。