今日共收錄 5 篇前額葉皮質相關文獻,涵蓋多個研究領域。
Journal of affective disorders · Relationship between cognitive function and brain activation in late-life depression patients with and without frailty: a functional near-infrared spectroscopy study.
研究發現併發虛弱的晚年抑鬱患者(F-LLD)在認知功能與左側背外側前額葉皮質(DLPFC_L)激活顯著低於無虛弱組及健康對照組,且虛弱程度與 DLPFC_L 激活負相關,支持其為虛弱相關認知功能障礙的神經相關因子。
Phytomedicine : international journal of phytotherapy and phytopharmacology · Antidepressant mechanism of sns in repairing synaptic damage via the GPR120/NLRP3 pathway-mediated inhibition of microglial M1 polarization.
傳統中醫方劑 Sinisan (SNS) 透過其活性成分 stigmasterol 誘導 GPR120 內質化,抑制 NLRP3 小體激活與小膠質 M1 極化,從而減輕前額葉突觸損傷及抑鬱様行為,揭示其抗抑鬱作用的分子機制。
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · Effects of prefrontal transcranial direct current stimulation on open-label placebo responses.
前額葉 tDCS 雖能緩解對照組的情緒困擾,但未增強開放式安慰劑(OLP)群的安慰劑反應,顯示 OLP 效應可能不完全依賴前額葉-mediated 的預期機制,提示其神經基礎與傳統欺騙性安慰劑有別。
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · Associations among mediodorsal thalamic-ventrolateral prefrontal cortical white matter fiber dispersion and OCD-related incompleteness.
研究發現中腦背側核(MD)與腹外側前額葉皮質(VLPFC)之間的纖維取向分散度(ODI)增加與強迫症患者的「不完整感」症狀顯著正相關,提示此通路在認知-情感控制中的關鍵作用,且兩個 MD 細胞亞型(MDPC、MDMC)共同參與此程序。
Pharmacology, biochemistry, and behavior · Cannabigerol improves MK-801-induced long-term recognition memory deficit in male rats through cortical TrkB-R signaling independently of changes in BDNF.
CBG 給予能逆轉 MK-801 誘導之長期識別記憶障礙,且此過程與海馬及前額葉 BDNF 水平無關,但顯著上調前額葉 TrkB-R mRNA,提示 CBG 可能經由 BDNF 獨立的 TrkB-R 活化來維持突觸可塑性與認知功能。