今日共收錄 30 篇前額葉皮質相關文獻，涵蓋多個研究領域。
Neuroscience bulletin · Cocaine Hijacks the Npas4-dependent Somatostatin Ensembles in the mPFC to Mediate Attention
研究發現單次可卡因注射會增加小鼠mPFC中Npas4轉錄依賴性神經元群體（N-RAM）及其與生長抑素互通神經元（N-RAM+ SST-IN）的共同激活，此機制促進來自中背丘的興奮性突觸輸入。抑制這些神經元群體會損害5選擇序列反應時間任務中的注意力表現，揭示其在可卡因導致注意缺陷中的關鍵角色。
eNeuro · GluN2A Enables Noradrenergic Control of Prefrontal Oscillations and Cognitive Flexibility
研究證明GluN2A含NMDA受體對於藍斑（LC）到mPFC的去甲腎上腺素輸入調節網絡振盪（尤其gamma頻段）及反轉學習是必要的。GluN2A缺失會導致振盪反應消失，並伴隨前調皮質中LC軸突密度增加與去甲腎上腺素轉運蛋白上調，提示發育性補償機制。此結果支持α2-腎上腺素受體路徑為改善前額葉網絡協調的治療標的。
Journal of computational neuroscience · Computational modeling of prefrontal-amygdala circuits links functional connectivity alterations to circuit-level mechanisms in major depression
利用改良的Jansen-Rit神經質量模型結合靜態fMRI功能連通性數據，研究模擬了前額葉-杏仁核電路在健康與抑鬱狀態下的動態。結果顯示，在健康狀態下杏仁核透過底向調節維持穩定並支持情緒調節；而在抑鬱狀態下，杏仁核過度激活會抑制腹內側前額葉並激活前扣帶皮質前部，導致認知調節與情緒失衡的異常電路狀態。此模型提供了一種機制性框架來理解功能連通性改變如何導致抑鬱症狀。
Journal of physical activity & health · Parent-Reported 24-Hour Movement Behaviors Movement Behaviors for Preschool Children: Evidence From Iraq
在伊拉克學前兒童（4-6歲）中，家長報告的中等至劇烈身體活動（MVPA）與睡眠時長與執行功能（經Head-Toes-Knees-Shoulders Revised任務測量）顯著正相關，而久坐行為與休閒螢幕時間則顯著負相關。組成數據分析進一步證實，相對於其他行為的MVPA比例以及相對於清醒時的睡眠比例，是預測更佳執行功能的獨立因子。此結果強調了在早期兒童發展中，平衡的24小時行為模式對執行功能的重要性。
Neuroreport · Frequency-dependent alterations of degree centrality in patients with poststroke depression: a resting-state functional MRI study
中風後抑鬱（PSD）患者在右側背外側前額葉皮質（DLPFC）於傳統、slow-4及slow-5頻帶均表現出持續降低的度中心性；而在slow-4頻帶中，左側DLPFC度中心性降低與自評抑鬱量表分數負相關，而左側蒼白球度中心性升高則與抑鬱嚴重程度正相關。此外，PSD組在slow-4帶中左側顳葉中迴、梭狀迴及胼胝體顯著增加度中心性。結果顯示slow-4帶為PSD中功能連通性異常最顯著的頻帶，提供了頻率特異性的神經生物標的。
Psychoradiology
BACKGROUND: Transcranial Magnetic Stimulation targeting the dorsolateral prefrontal cortex (DLPFC) is a therapeutic approach for treating depressive disorder. However, traditional anatomical methods o...
eNeuro
Transcranial direct current stimulation (tDCS) could reduce the neurophysiological effects in Alzheimer's disease (AD), but progress is hampered by variable outcomes across studies, likely related to ...
Biological psychiatry. Cognitive neuroscience and neuroimaging
BACKGROUND: Understanding how exposure-based trauma treatment modifies neural representations of trauma memory may lead to optimized and targeted interventions for posttraumatic stress disorder. Altho...
Biological psychiatry. Cognitive neuroscience and neuroimaging
BACKGROUND: Identifying reproducible neural markers of bipolar disorder(BD) risk is critical for early detection and differentiation from unipolar/major depression. We previously demonstrated that int...
Brain stimulation
BACKGROUND: Schizophrenia spectrum disorders (SSDs) often feature debilitating social cognitive impairments, with limited treatment options. This study used a target engagement approach to examine the...
NeuroImage
OBJECTIVE: Menopausal symptoms had a continuous impact on women's well-being, with mood disturbances representing a core manifestation. To further support treatment decisions, objective neurophysiolog...
Biological psychiatry
BACKGROUND: Somatic symptom disorder (SSD) exhibits substantial clinical heterogeneity that limits treatment efficacy, with over 40% of patients failing to respond to standard interventions. Here, we ...
Neuroscience letters
Parkinson's disease (PD) is characterized by progressive dopaminergic neuron loss and motor and non-motor impairments. Mitochondrial dysfunction and altered post-translational modifications, including...
Science advances
How does the human brain detect and respond to disruptions in breathing? While animal studies have advanced our understanding of respiratory control, breathing distress in humans remains difficult to ...
Cell reports
Monoaminergic nuclei such as the serotonergic dorsal raphe nucleus (DRN) receive functionally distinct streams of synaptic inputs, yet whether and how these are transformed into distinct population co...
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
OBJECTIVES: Suicide is a complex phenotype influenced by genetic, environmental, and psychosocial determinants. Epigenetic mechanisms, particularly DNA methylation, play a critical role in mediating t...
Cognitive, affective & behavioral neuroscience
This article proposes that Pavlovian learning contributes to the formation and stabilization of social beliefs and collective commitments. We argue that associative processes linking reward and threat...
Journal of affective disorders
INTRODUCTION: Treatment-resistant depression (TRD) is a heterogeneous condition in which symptoms such as anhedonia, rumination, and anxiety contribute to persistent disability. Esketamine nasal spray...
Journal of affective disorders
BACKGROUND: Expressive suppression is associated with rumination, but the cortical functional connectivity (FC) patterns characterizing this relationship remain unclear in adolescents with major depre...
Neuropharmacology
BACKGROUND: Rheumatoid arthritis (RA) is often associated with neuropsychiatric comorbidities; yet, little is known about the central neurobehavioral fingerprints of disease-modifying antirheumatic me...
Ergonomics
Whether neuroimaging findings from university student samples generalise to occupational populations has rarely been tested. Using portable functional near-infrared spectroscopy (fNIRS), we compared p...
Psychopharmacology
RATIONALE: Psilocybin (PSI) microdosing, defined as a repeated administration of sub-perceptual doses, has gained increasing attention as a potential therapeutic strategy for affective and anxiety dis...
Applied neuropsychology. Child
This exploratory study investigates the effectiveness of EEG-guided Transcranial Magnetic Stimulation (TMS) in treating children with Autism Spectrum Disorder (ASD). ASD is a neurodevelopmental disord...
Neuroscience
Major depressive disorder (MDD) frequently coexists with chronic pain in women. Olfactory bulbectomy (OBX) is a validated animal model of depression. In male rodents, OBX induces allodynia and glial a...
GeroScience
Aging is accompanied by progressive epigenetic alterations, including changes in DNA methylation affecting both gene-associated regions and repetitive elements such as LINE-1 retrotransposons. Reduced...
Neuroscience letters
According to Braak's staging hypothesis, Parkinson's disease (PD) pathology may originate in extranigral regions, including the locus coeruleus (LC). In parallel, PD has been associated with lysosomal...
Neuroscience letters
Major depressive disorder (MDD) involves cognitive impairment, altered affective states and dysregulation of neurotransmitter homeostasis. The Wistar Kyoto (WKY) rat is characterized by inherent depre...
Behavioural brain research
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social behavior and cognition. Increasing evidence suggests that alterations in dopaminergic neurotransmis...
Neurobiology of disease
Posttraumatic stress disorder (PTSD) affects more than 9% of the population, and currently FDA-approved treatments show limited efficacy. There is therefore an urgent need to better understand the und...
Neuroscience bulletin
Acute stress rapidly reshapes brain function to promote adaptive behavioral responses. Although dysfunction of the medial prefrontal cortex (mPFC)-amygdala circuit is well established in chronic stres...