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Real-life durability and virological outcomes of doravirine in people with multidrug-resistant HIV.
AIDS (London, England)
評估多重耐藥HIV患者使用多西他滨含 regimens 的長期穩定性與病毒抑制效果,發現於非病毒血症啟用者中維持率達82.6%。
Bulk ferroelectric heterostructures.
Science advances
透過奈米級元素分割在鐵電材料中創造體積鐵電異結構,顯著提升居里溫度與壓電響應,為高溫壓電應用提供新平台。
Financial Effects of an Out-of-Pocket Cap in Traditional Medicare.
JAMA health forum
模型顯示引入每年3000美元自付上限將顯著降低受益人自付費用並增加醫療保險支出,且促使受益人從醫療保險優勢計畫轉回傳統醫療保險。
Interfacial gating of nano-ampere resistive switching in Si/SiOx/ZnO heterostructures for energy-efficient electronics.
Materials horizons
示範Si/SiOx/ZnO異結構可透過橫向電場閘控實現低功率、可程式化的電阻切換,適適用於類神經運算。
Culture-Agnostic and Culture-Specific Analyses of Semantic Fluency in Korean and English Speakers With Alzheimer's Disease.
American journal of speech-language pathology
發現韓語阿茲海默症患者的語義流暢受東西方文化圖式(如生肖)影響,僅具文化特異性分析才能揭露其與全球認知之關聯。
Genes Do Not Read DSM: Tuberous Sclerosis Complex May Dominate with Multi-Neuropsychiatric Symptoms.
Harvard review of psychiatry
一例結節性硬化症患者表現為治療難治性驚恐發作伴去真實感,最終經腦電圖與神經影像確認為左前顳葉癲癇,提醒精神症狀需警鑑器質性原因。
A multifunctional Janus metamaterial with a tunable anisotropic layer for universal Laplacian field control.
Materials horizons
提出可動態重組的雙面超材料,藥由各向異導電層實現對熱與電場的濃度、旋轉與透明度切換,提供通用拉普拉斯場調控框架。
Multiple electronic states in a chiral nanographene through NH manipulation.
Chemical communications (Cambridge, England)
透過氮氫基團調控手性納米石墨烯的電子狀態,成功產生 radical cation、中性 radical 與 anion 三種態,並實現可逆手性光學切換。
Investigation of the Effects of Switching from Bosentan to Macitentan in Pediatric Pulmonary Hypertension Patients.
Sisli Etfal Hastanesi tip bulteni
小兒肺動脈高壓患者由波森坦轉用馬西坦後,6個月內WHO功能級改善、血清指標下降及6分鐘步行距離增加,未見顯著不良反應。
Water-Mediated Reversible Crystalline Phase Transformation Enables Color Switching and Circularly Polarized Luminescence Handedness Inversion.
Angewandte Chemie (International ed. in English)
離子晶透過水合/脫水循環實現晶間相變,伴隨發光顏色由黃轉紅及圓偏振發光左右手完全反轉,顯示可逆光學響應具有多週穩定性。
Conformationally Switchable Copper(I) Complexes Amplify BODIPY Triplet Photosensitization.
Angewandte Chemie (International ed. in English)
結合構象可切換銅(I)複合物與BODIPY色素,可提升三重態光敏劑效率,使上轉換量子產率從6.6%提升至12.1%。
BRIP1, a G-quadruplex DNA helicase, protects against AID-induced genomic instability by limiting R-loop accumulation.
Molecular medicine (Cambridge, Mass.)
BRIP1 參與解決非B型DNA結構(如R-loop與G4),其缺失會增加AID誘導的基因體不穩定性,包括斷裂與易位,揭示其在預防B細胞淋巴瘤中的潛在機制。
Evidence for Site-Specific Tunneling in H Atom Uptake at the Surface of Polyoxovanadate-Alkoxides.
JACS Au
在特定橋氧位點,氫原子的吸收遵循量子穿隧機制(KIE與溫度無關),而在端 vanadyl 位則呈現半經典PCET,顯示位點基本性對穿隧具有關鍵影響。
Ultrafast proton delivery with pin ridge filters (pRFs): repurposing single-energy delivery for motion management in proton therapy.
Physics in medicine and biology
使用嵴狀過濾器(pRF)消除能量層切換,大幅縮短質子治療束開時間(平均縮短83.4%),並改善劑型 conformality 與降低正常組織劑量。
Antibacterial sterilization performance of fluorosiloxane acrylate enhanced by magnetic field-assisted plasma.
Colloids and surfaces. B, Biointerfaces
橫向磁場增強等離子體處理氟硅氧烷丙烯酸酯,可將表面改質為親水且具奈米拓樸,使大腸桿菌與金黃色葡萄球菌在15W/18分鐘內滅活至檢測限以下。
A G4-nanotweezer/DNA tetrahedron-confined dual-mode ECL/SERS biosensor for ultrasensitive rabies viral RNA detection via CRISPR-Cas12a-regulated hemin switching.
Talanta
利用DNA四面體限域的G4奈米鎗結合CRISPR-Cas12a調控的血紅素切換,實現瘟病毒RNA的雙模式(ECL/SERS)超靈敏檢測,偵測極限達0.0675 aM。
Non-coding RNAs as mediators of tyrosine kinase inhibitor resistance in chronic myeloid leukemia: a scoping review.
Cancer treatment and research communications
非編碼RNA(特別是miRNA、lncRNA、circRNA)在慢性粒白血病中介導TKI抗性,主要經由PI3K/AKT、RAS/MAPK及autophagy通路調控,具有成為生物標記或治療標的之潛力。
E-cigarette puffs per day and changes in cigarettes per day among combustible cigarette smokers with opioid use disorder: A secondary analysis of the Electronic Cigarettes to Address Combustible Cigarette Smoking for People With opioid use disorder (ERASER) study.
Experimental and clinical psychopharmacology
在阿片使用障礙菸民中,成功將菸害減少50%以上者(減少組)在早期階段增加電子菸吸食次數並維持,而未達標組則後期減少,顯示吸食頻率模式可預測戒菸成效。
Large-Area Polyaniline/Carbon Nanotube Composite Film for the Zn-Ion Electrochromic Window toward Energy-Sustainable Buildings.
ACS applied materials & interfaces
透過奈米管介層與雙陰極設計,製備大面積PANI/CNT複合膜用於鋅離子電致變窗,達成82.3%光學調制、快速切換(5.8s/4.6s)及可儲存能量,模擬日照下可降溫6.6℃。
Steep-Slope MoS2 and WSe2 Field-Effect Transistors Enabled by Ag/SiO2 Atomic Threshold Switches for Static-Power-Suppressed Complementary Inverters.
ACS applied materials & interfaces
整合原子閾值開關(ATS)與MoS2/WSe2製作陡斜率CMOS逆變器,實現極低靜態功耗(SS <5 mV/dec)並在準邏輯區維持逆變器操作,動態與靜態功耗存在權衡。
Ligand-Directed Molecular Beacons as Turn-On Fluorescent Probes for Sensing Cell-Surface Receptor-Ligand Interactions.
Angewandte Chemie (International ed. in English)
設計可配體導向的分子探針(MB)平台,藉由空間鄰近與構象切換實現低背景細胞表面受體成像,並可經簡易更換螢光團與配體調節發射波長、親和力與價數。
Resolution of restless legs syndrome after postdilution online hemodiafiltration using a vitamin E-bonded polysulfone membrane: a report of two cases.
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs
兩例長期難治性腳底不安症患者,在經標準線上血液透析濾過無效後,改用後稀釋模式含維他命E結合聚砜膜之血液透析濾過,顯著改善症狀,提示稀釋方式與膜材質對療效具有關鍵影響。
Drug Brand Switching: A Regulatory Perspective.
Drug safety
探討原廠藥與仿制藥切換時如何因規範框架(如生物等效標準)導致患者不適或療效下降,並指出藥物基因學可能有助於減輕此類問題。
NFAM1 organizes a lipid raft-restricted DAPP1-PLCG2 module to drive M2-like GAM polarization via Ca²⁺-NFAT1 signaling in glioma.
Neuro-oncology
NFAM1在膜筏中組織DAPP1-PLCG2-Ca²⁺-NFAT1訊號模組,促進類樣巨噬細胞M2極化與惡性膠質瘤進展,其調控具治療標的潛力。
IADVL consensus recommendations on Trichophyton indotineae infections: Using modified Delphi method.
Journal of the European Academy of Dermatology and Venereology : JEADV
針對新興致癥真菌Trichophyton indotineae建議使用伊曲康唑為首選全身治療, terbinafine 高劑量為二線,治療不足時考慮更換藥物並維持至癒,並提供特別人群用藥指引。
Investigation of Wnt2's Role in Macrophage Polarization and Its Effects on Sepsis.
Immunological investigations
Wnt2透過經典Wnt/β-catenin通路調節巨噬細胞極化,影響NF-κB與代謝重程,在敗血症中維持M1/M2平衡,保護肺腸心臟肝臟器官,提供免疫治療理論基礎。
Mixed-valence molecules as platforms for ultrafast cooling via sudden electric-field switching.
The Journal of chemical physics
提出利用雙核混合價分子在電場驟降下吸熱(冷凍)機制:驟降破壞熱平衡,介電弛豐時 phonon 浴向量子系統傳熱,實現環境降溫,適合於強耦合或弱電轉系統。
Real-World Postdischarge P2Y12 Inhibitor Use After Ischemic Stroke and Transient Ischemic Attack, 2020 to 2024.
The Annals of pharmacotherapy
僅約18.9%的缺血性中風/TIA患者在出院後30天內領得P2Y12抑制劑,克洛吡格爾為主要用藥(94.9%),持續使用率低,藥物切換現象少見。