今日文獻聚焦於 BPD 的多面向研究,涵蓋神經生物學機制(如白質病變與應激反應)、臨床表現(如脆弱型自戀共病)、功能復原(日常生活功能)、診斷障礙與治療介入,反映臨床從症狀導向轉向功能復原與早期識別的趨勢。
Personality and mental health · When Guidelines Are Not Enough: Clinician Hesitation to Diagnose Borderline Personality Disorder in Adolescents as a Barrier to Timely Evidence-Based Care.
臨床醫師對診斷青少年BPD的猶豫導致延遲治療,儘管指南建議早期介入,此現象反污名化與臨床不確定性是主要阻礙,需透過教育與制度支援突破。
Australian occupational therapy journal · A qualitative description of the daily living functioning of people diagnosed with borderline personality disorder from consumer, carer and clinician perspectives.
BPD患者在建立結構化日常routine、管理情緒與人際所需能量、脫離價值觀的行為模式及依賴他人完成任務方面顯著受損,職能治療師在功能復原中具關鍵角色。
Personality and mental health · Vulnerable Narcissism in Borderline Personality Disorder: Impact on Emotion Dysregulation, Identity Disturbance, and Rejection Sensitivity in Psychiatric Inpatients.
合併脆弱型自戀(VN)的BPD住院患者顯著較純BPD組或其他組有更嚴重的情緒失調、身份 disturbed、拒絕敏感度、自殺企圖與創傷暴露,提醒臨床師需積極篩選此高風險亞型。
Journal of affective disorders · Mineralocorticoid receptor stimulation effects on stress-induced cortisol and alpha-amylase in female patients with borderline personality disorder and healthy controls: A randomized placebo-controlled experimental study.
BPD女性在社會壓力下皮質醇反應遲鈍,但外源性腎上腺皮質素受體激動劑(fludrocortisone)未能正常化此反應,提示HPA軸遲鈍非主要由過度MR-mediated反饋引起。
Psychiatry research. Neuroimaging · Symptom correlates of white matter pathology in borderline personality disorder: A narrative review of a structured pubmed search.
BPD患者在胼胝體、 cingulate 皮質及 superior longitudinal fasciculus 等區域反覆出現白質病變,其中胼胝體完整性與焦慮相關,三網路白質連結與自殺/攻擊行為有特別關聯。
Brain, behavior, & immunity - health
懷孕期間的精神疾病(含BPD)與高血壓、早產、胎兒生長異常、手術分娩及新生兒併發症風險增加相關,但證異質性高,呼籲超越以憂鬱為中心的產前精神醫學框架。
World psychiatry : official journal of the World Psychiatric Association (WPA)
利用全國基因資料與網絡分析發現,BPD遺傳風險與自殺未遂、雙極極性障礙、內化與外化障礙、飲食障礙等具有廣泛關聯,凸�其複雜的共病遺傳架構。
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
右側DLPFC刺激主要改善沖動,左側DLPFC改善情緒調節與冷認知功能,右側VLFC可能緩解拒絕相關情緒反應;NIBS與心理治療結合可行但加成效應尚不明確。