今日文獻聚焦於雙相情緒障礙症的精準醫療與數位監測,涵蓋長效針劑抗精神病藥物的維持治療實證、智慧手錶預測復發的可行性,以及基因多態性與生物標記在鑑別診斷上的潛力。
Therapeutic delivery · An evaluation of aripiprazole long-acting injectable monthly and bimonthly in the maintenance treatment of bipolar I disorder.
阿立哌唑長效針劑能有效降低雙相第一型躁狂與混合發作復發風險且耐受性良好,為提升藥物遵從性提供實證基礎。
Journal of affective disorders · Bipolar disorder relapse detection and prediction using smartwatches. A pilot study for machine learning models using anomaly detection methods.
結合智慧手錶生理數據與無監督式異常偵測演算法,能有效偵測雙相障礙症的憂鬱與輕躁狂復發,為數位精神醫學提供初步實證。
Journal of affective disorders · Differential analysis of CACNA1C polymorphisms among patients with depression and bipolar disorder and exploration of sleep as a mediator.
結合臨床風險因子與 CACNA1C 基因變異,可有效鑑別雙相障礙症與重鬱症,為初次發作憂鬱時的精準鑑別診斷提供新思路。
Journal of affective disorders · Evening chronotype is associated with affective temperaments, emotional dysregulation, and bipolar-spectrum features: An observational study in 1997 adults from a large community sample.
晚型晝夜節律與情緒失調、環性氣質及雙相光譜特徵顯著相關,顯示晝夜節律可作為篩檢雙相高危險群的重要標記。
BMC psychiatry · Association of anhedonia with brain-derived neurotrophic factor and oxidative stress in bipolar disorder.
雙相憂鬱發作患者的消費性快感缺失與 BDNF 濃度及過氧化氫酶(CAT)顯著負相關,揭示了無快感症背後的潛在神經生物學機制。
European neuropsychopharmacology
研究發現雙相障礙症與多內分泌代謝卵巢症候群具有共享基因位點(如 CACNA1C),且 Valproate 可能與這些共同基因路徑產生交互作用。
PCN reports : psychiatry and clinical neurosciences
個案報告提醒,圍絕經期婦女出現首發躁狂症狀時,需高度懷疑自體免疫或神經發炎疾病(如多發性硬化症),並應常規安排腦部 MRI。