⭐今日精選 TOP Picks
Social isolation recruits amygdala-medial prefrontal cortex projections to escalate alcohol drinking in male mice.
Nature neuroscience · Social isolation recruits amygdala-medial prefrontal cortex projections to escalate alcohol drinking in male mice
揭示社交隔離透過BLA-mPFC神經通路調控男性小鼠酒精飲酒行為，找到潛在干預靶點。
P男性小鼠
I社交隔離模型與BLA-mPFC路徑操控
C自由社交的對照組
O飲酒量顯著增加，且BLA-mPFC活性與飲酒正相關
The effect of resilience on alcohol use and alcohol-related outcomes: A systematic review and meta-analysis.
Clinical psychology review · The effect of resilience on alcohol use and alcohol-related outcomes: A systematic review and meta-analysis.
高彈性與更低的酒精相關不良結果顯著相關，提示韌性可作為預防與治療的保護因素。
P全球研究樣本（24項研究）
I韌性測量與比較
C對照組/低韌性組
O韌性每提升1單位，酒精相關問題風險下降約9%。
Clinical effectiveness and safety of metadoxine in the management of acute alcohol intoxication: A single-center retrospective cohort study.
Pakistan journal of pharmaceutical sciences · Clinical effectiveness and safety of metadoxine in the management of acute alcohol intoxication: A single-center retrospective cohort study.
Metadoxine顯著縮短意識恢復時間、提升治療成功率，且未增加不良事件，適合急性酒精中毒標準療法。
P急性酒精中毒患者
IMetadoxine加常規治療
C常規治療單獨
O意識恢復時間縮短2.6小時，治療有效率提升15%左右
Phenobarbital Versus Benzodiazepine-Based Pathways for Alcohol Withdrawal Syndrome in Critically Ill Adults: A Systematic Review and Meta-Analysis.
Pharmacotherapy · Phenobarbital Versus Benzodiazepine-Based Pathways for Alcohol Withdrawal Syndrome in Critically Ill Adults: A Systematic Review and Meta-Analysis.
Phenobarbital方案在某些情境下縮短ICU停留時間，但整體安全性與效果尚需更多高品質研究驗證。
P重症酒精戒斷患者
IPhenobarbital驅動的路徑
CBenzodiazepine驅動的路徑
OICU住院日減少約0.6天，但端點差異不顯著
Relation between serum oxytocin levels and impulsivity in patients under treatment for alcohol use disorder.
International journal of psychiatry in clinical practice · Relation between serum oxytocin levels and impulsivity in patients under treatment for alcohol use disorder.
血清緣二醇水平與衝動性呈負相關，提示 oxytocin 可能調節 AUD 的衝動機制。
P接受AUD治療的患者
I測量血清oxytocin與BIS-11量表
C健康對照組
Ooxytocin水平較低，衝動性較高，且負相關顯著
Canine-Associated Capnocytophaga canimorsus Bacteremia in an Older Adult Without Classical Immunosuppressive Risk Factors.
The American journal of case reports · Canine-Associated Capnocytophaga canimorsus Bacteremia in an Older Adult Without Classical Immunosuppressive Risk Factors.
細菌性血症在無傳統免疫抑制風險因子的老年人中仍可發生，提醒醫師注意酒精使用者的感染風險。
P年長成人（無免疫抑制）
ICapnocytophaga canimorsus感染治療
C一般感染案例
O需早期抗生素介入，預防重症化。
Targeting PAI-1 with TM5441 Mitigates Chronic Social Stress-Induced Anxiety-Like Behavior and Stress-Induced Increases in Ethanol Intake and Preference.
Neurochemical research · Targeting PAI-1 with TM5441 Mitigates Chronic Social Stress-Induced Anxiety-Like Behavior and Stress-Induced Increases in Ethanol Intake and Preference.
PAI-1抑制劑可逆轉壓力誘發的焦慮行為與酒精偏好，提供新治療方向。
P實驗性小鼠
ITM5441藥物阻斷
C未處理壓力組
O焦慮行為與酒精飲用量恢復至對照水平。
📚其他值得關注的文獻
Editorial: Predictors of Engagement and Impact on Alcohol-Related Hospital Utilization with Primary Care-Based Alcohol Use Disorder Treatment Clinic.
Journal of general internal medicine
聚焦於預測因素與介入對策，協助医院提升酒精使用障礙患者的介入成功率。
Phenobarbital Versus Benzodiazepine-Based Pathways for Alcohol Withdrawal Syndrome in Critically Ill Adults: A Systematic Review and Meta-Analysis.
Pharmacotherapy
Phenobarbital方案在某些情境下縮短ICU停留時間，但整體安全性與效果尚需更多高品質研究驗證。
The effect of resilience on alcohol use and alcohol-related outcomes: A systematic review and meta-analysis.
Clinical psychology review
高彈性與更低的酒精相關不良結果顯著相關，提示韌性可作為預防與治療的保護因素。
Clinical effectiveness and safety of metadoxine in the management of acute alcohol intoxication: A single-center retrospective cohort study.
Pakistan journal of pharmaceutical sciences
Metadoxine顯著縮短意識恢復時間、提升治療成功率，且未增加不良事件，適合急性酒精中毒標準療法。
Relation between serum oxytocin levels and impulsivity in patients under treatment for alcohol use disorder.
International journal of psychiatry in clinical practice
血清緣二醇水平與衝動性呈負相關，提示 oxytocin 可能調節 AUD 的衝動機制。
Canine-Associated Capnocytophaga canimorsus Bacteremia in an Older Adult Without Classical Immunosuppressive Risk Factors.
The American journal of case reports
細菌性血症在無傳統免疫抑制風險因子的老年人中仍可發生，提醒醫師注意酒精使用者的感染風險。
Phenobarbital Versus Benzodiazepine-Based Pathways for Alcohol Withdrawal Syndrome in Critically Ill Adults: A Systematic Review and Meta-Analysis.
Pharmacotherapy
Phenobarbital方案在某些情境下縮短ICU停留時間，但整體安全性與效果尚需更多高品質研究驗證。