今日文獻聚焦於酒精使用疾患的併發症、性別差異、社會決定因素與新興治療方法,尤其顯著探討酒精性肝病、神經機制與心理社會因素之互動,顯示跨領域整合趨勢明顯。
The American journal of the medical sciences · Clinical and In-Hospital Outcomes of Alcohol-Related Pancreatitis in the Setting of Concomitant Alcohol-Related Hepatitis: A Retrospective Cohort Study.
併發酒精性肝炎的酒精性胰腺炎患者住院死亡率顯著上升,並與敗血症、急性腎損傷、呼吸衰竭等多重器官併發症顯著相關,提示需早期篩檢與多科整合照護。
Journal of hospital medicine · Causes of death among veterans with alcohol use disorder-related conditions: A 5-year follow-up study of Veterans Health Administration hospitalizations.
有酒精使用疾患相關診斷的退伍軍人死亡年齡較較早(62.0 vs 72.7歲),且胃腸道疾病與外部原因(如意外、自殺)是主要死因,凸�顯需強化出院後連結與篩檢。
Hepatology research : the official journal of the Japan Society of Hepatology · Long-Term Effects of Nalmefene on Alcohol Consumption, Liver Function, and Gut Microbiota in Patients With Alcohol-Related Liver Disease.
納美芬在酒精性肝病患者中於第4個月起顯著減少重複飲酒日與總酒精攝入,伴隨ALT/AST改善及腸道Proteobacteria與Klebsiella減少,提示其雙重治療潛力。
Alcohol (Fayetteville, N.Y.) · Alcohol Expectancies, Emotional States, and Alcohol-Related Consequences among Junior College Students in China: A Full Mediation Model of Alcohol Consumption.
正負情緒與正向酒精期待值經由酒精消費完全中介對酒後主觀感受與危害的影響,強調飲酒為心理調節的關鍵機制,而非直接帶來益處。
Biological psychiatry global open science · Prazosin-Related Reductions in Daily Craving Mediate Treatment-Related Daily Alcohol Use Outcomes in Alcohol Use Disorder.
普拉佐辛顯著降低每日酒精慾望,且此慾望減少中介了其對隔日飲酒的影響(66.7% 效應經由此路徑),安慰劑組則無此 mediate 效應,支持其抗慾望機制。
Drug and alcohol review
被他人飲酒傷害的嚴重程度與該飲酒者的每週酒精量及Heavy Episodic Drinking頻率呈正向劑量反應關係,提示減少高頻重複飲酒可獲額外公共衛生效益。
Journal of addictive diseases
透過k-means聚類識別出三種AUD表型:Late-Onset(高戒斷率)、High-Functioning(高社經)、Severe(早發、高共病、高慾望,戒斷率最低),並發現復發風險主要由慾望與共病驅動而非嚴重程度評分。
Annals of medicine
醫用乙醇被視為資源 efficient 與整體性的戒斷策略,但醫護人員對其獨立開處仍缺乏信心,凸顯需教育與制度支援以擴大應用。
Brain, behavior, & immunity - health
儘管AUD患者基礎IL-6與CRP顯著升高,但其對急性壓力的IL-6反應幅度與健康對照組無顯著差異,提示慢性炎症與急性應激通路可能獨立調節。
Phytomedicine : international journal of phytotherapy and phytopharmacology
貝殼苷A透過結合FXR並增強其對FOXA2的轉錄激活,減少酒精誘導的肝脂肪变性、脂質積聚與氧化應激,提供中藥潛在療法的機制依據。