今日文獻聚焦於青少年雙相情緒障礙的藥物治療證據(尤其是混合型特征)、大麻使用對再住院的影響,以及遺傳風險與社會功能之間的關聯,顯示出精準醫療與早期干預的研究趨勢。
Journal of affective disorders · Pharmacological interventions for acute major depression and bipolar depression with mixed features: A systematic review and dose-related network meta-analysis across different age groups.
在青少年和成人中,拉西多酮60mg/日及80mg/日對降低雙相混合型抑鬱症狀具有顯著效果,優於安慰劑,提供具體劑量指引用於臨床決策。
The Journal of clinical psychiatry · Impact of Cannabis Use on Time to Psychiatric Rehospitalization in Young Adults With Bipolar and Psychotic Disorders: A Survival Analysis.
雙相或精神病青年住院時若有大麻使用,則在出院後1個月內再住院風險增加2.8倍,提示早期戒斷介入的關鍵時窗。
Molecular psychiatry · Investigating the associations between neurodevelopmental and psychiatric genetic liability and adverse social and functional outcomes across childhood, adolescence and young-adulthood.
ADHD 多基因分數與同儕問題、較低教育成就/就業及兒童自殺行為顯著相關,顯示基因風險可透過社會功能表現早於臨床診斷被偵測。
The American journal of psychiatry · Individualized Connectivity-Guided Versus Conventional Targeting of Accelerated Theta-Burst Stimulation in Depression: A Randomized, Double-Blind, Parallel-Design Trial.
結構連結引導式(iTBS)在減少HAM-D分數方面優於常規5公分規則,效果在第2週顯著且持續至第6週,支持個體化神經刺激目標定位的潛力。
American journal of ophthalmology · Noninfectious Uveitis is Associated With Increased Psychiatric Comorbidities: An All of Us Research Program Analysis.
非傳染性葡萄膜炎患者中雙相障礙發病率為7.8%,是對照組的2.16倍,提示需關注此類免疫相關疾病中的精神共病篩檢。