⭐今日精選 TOP Picks
ICER-Controlled inhibitory plasticity of amygdala engram neurons regulates fear memory precision.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · ICER-Controlled inhibitory plasticity of amygdala engram neurons regulates fear memory precision.
發現ICER通過下調Gabra1表達抑制前庭杏仁核抑制性可塑性，導致恐懼過度概化，為PTSD中恐懼記憶精準化提供新治療標靶。
P小鼠恐懼條件反射模型
I操縱PARVALBUMIN陽性介內細胞活性或Gabra1表達
C對照組（未操縱）
O恐懼辨識精度與過度一般化行為
Racial Discrimination and PTSD Symptoms Among Black Women: The Mediating Roles of Anxiety and Depression.
Journal of racial and ethnic health disparities · Racial Discrimination and PTSD Symptoms Among Black Women: The Mediating Roles of Anxiety and Depression.
種族歧視透過焦慮與憂鬱間接影響黑人女性PTSD症狀，支持將種族創傷納入PTSD概念模型及導向情緒調節干預。
P377名芝加哥黑人女性
I種族歧視暴露程度
C低暴露組
OPTSD症狀（透過焦慮與憂鬱的中介效應）
Postintensive Care Syndrome in Surgical Patients: A Scoping Review.
Journal of trauma nursing : the official journal of the Society of Trauma Nurses · Postintensive Care Syndrome in Surgical Patients: A Scoping Review.
手術ICU患者在出院後一年內普遍出現PICS症狀，其中心理健康問題（含PTSD）短長期皆常見，提醒需長期追蹤。
P3310名手術ICU患者
I無（範圍性回顧）
C無
OPICS症狀（認知、身體、心理、社會）
Brain structural covariance networks in co-occurring PTSD and alcohol use disorder: An ENIGMA PTSD and ENIGMA addiction working group collaboration.
Progress in neuro-psychopharmacology & biological psychiatry · Brain structural covariance networks in co-occurring PTSD and alcohol use disorder: An ENIGMA PTSD and ENIGMA addiction working group collaboration.
共病PTSD與酒精使用障礙者在額葉與顳葉結構網絡顯示共異改變，且併發組見額葉外加枕葉區域異常，提示共病具有獨特神經生物學特徵。
P1565名來自14個研究站點的受試者（含PTSD、AUD、共病、創傷暴露對照、非創傷暴露對照）
I無（觀察性結構連結網絡分析）
C創傷未暴露對照組
O結構連結網絡（SC）改變模式
Prediction models for postpartum post-traumatic stress disorder: a systematic review and meta-analysis.
Archives of women's mental health · Prediction models for postpartum post-traumatic stress disorder: a systematic review and meta-analysis.
產後PTSD預測模型顯示moderate預測力（AUC 0.84），但異質性高及缺乏外部驗證限制其臨床應用，需標準化報告與多中心驗證。
P17,236名產後女性
I多變項預測模型（產後12個月內）
C無模型（自然病史）
OAUC、敏感度、特異度
Online stepped care for the treatment of posttraumatic stress disorder: A randomized controlled noninferiority trial.
Behaviour research and therapy · Online stepped care for the treatment of posttraumatic stress disorder: A randomized controlled noninferiority trial.
線上階梯式療法（TWU → CPT）在減 clinician 費用且非劣於標準CPT治療PTSD（ clinician 評分），但保留率較低，顯示其可行性與改進空間。
P84名成人PTSD及臨界PTSD患者
I線上階梯式療法（TWU作步驟1，若需則升級至CPT）
C透遠距醫療提供的標準CPT
OPTSD症狀（CAPS-5、PCL-5）、抑鬱、生活品質
Oxytocin preserves excitatory responsiveness of VTA dopaminergic neurons in PTSD model rats.
IBRO neuroscience reports · Oxytocin preserves excitatory responsiveness of VTA dopaminergic neurons in PTSD model rats.
雖PTSD模型鼠VTA多巴胺神經元基礎活性降低，但其對促織素的興奮性反應被保留，提示促織素系統在PTSD中仍具可塑性，為治療提供生理基礎。
P單一長期壓力（SPS） induced PTSD模型鼠
I腦室內給予促織素（OXT）
C正常對照鼠
OVTA多巴胺神經元的自發放電與突發活性
Mental Health Changes Among LGBTQIA+ Persons After the 2024 US Presidential Election.
American journal of public health · Mental Health Changes Among LGBTQIA+ Persons After the 2024 US Presidential Election.
2024年美國大選後，先前無顯著症狀的LGBTQIA+個體心理健康惡化，特別是跨性別與性別多樣化人士的焦慮與PTSD症狀，提醒醫護需主動關注此群體。
P2150名美國LGBTQIA+個體（縱向觀察隊列）
I2024年11月美國總統選舉
C選舉前（2023年6月－2024年5月）
O憂鬱、焦慮、PTSD症狀變化
📚其他值得關注的文獻
Healing our intergenerational wounds: a praxis of community healing envisioned by refugee young adults engaging in participatory avatar-based community circles.
International journal for equity in health
透過參與性虛擬社群圈，識別出難年輕人社群癒合的七個關鍵元素，強調文化安全、代際連結及去污名化為創傷復原核心。
Depressive symptom severity and treatment outcome in posttraumatic stress disorder following childhood trauma: A secondary analysis of a randomized clinical trial.
Journal of traumatic stress
基線憂鬱症狀嚴重度不影響創傷聚焦治療（EMDR或ImRs）對PTSD的療效，支持無論併發憂鬱程度皆應提供創傷聚焦介入。
Associations between psychological distress symptoms and cognitive function among trauma-exposed women: Moderating role of the developmental period of trauma exposure.
Journal of traumatic stress
創傷時點調節內化症狀與情緒認知功能的關聯：成年時首次創傷者焦慮與反應時間相關，青少年時首次創傷者憂鬱與情緒抑制相關。
Real-time fMRI neurofeedback of left dorsolateral prefrontal cortex to enhance emotional cognitive control: A randomized controlled trial.
NeuroImage
即時fMRI回饋訓練左側dlPFC活性可在短期內增加神經活性，但未顯著改善情緒認知控制行為表現，顯示神經靶標參與但缺乏持續傳遞至功能改善。
Cumulative burden of mild TBI in Veterans: Accelerated age-related regional white matter deterioration along major white matter pathways.
Neurobiology of aging
退伍軍人累積輕微創腦傷burden與年齡相關白質微結構惡化在特定通路（如 ventral cingulate bundle）顯著互動，提示mTBI加速大腦老化。
Combat Injury, Limb Loss, Traumatic Brain Injury, and Psychosocial Outcomes Among Military Personnel.
JAMA network open
英軍人員受戰鬥傷害者（尤其伴隨肢體斷裂或TBI）在超過十年後仍顯著增加報告PTSD、憂鬱、焦慮及多重精神疾病風險。
The Unseen Burden in Midwifery: Associations Between Workplace Violence, PTSD Symptoms, and Professional Quality of Life.
Journal of evaluation in clinical practice
土耳其護理師職場語言暴力顯著關聯較高PTSD症狀，而身體暴力則與職業滿足感相關，提醒需改善職場安全以保護身心健康。
Post-traumatic stress disorder: outline and updated insights focusing on occupational factors.
Journal of occupational medicine and toxicology (London, England)
職業性創傷暴露（如軍人、急救人員、醫護）是PTSD重要危險因子，且流行率與工作能力、工傷賠償密切相關，強調預防與早期介入的職場策略。
Associations between PTSD symptom clusters and multi-region pain in young adults with chronic pain.
Journal of behavioral medicine
在年輕慢性疼痛者中，PTSD過覺醒症狀獨立預測多區域疼痛，提示該症狀可能是介入多部位疼痛的關鍵靶標。
Immunometabolic alterations in post-traumatic stress disorder.
Brain, behavior, and immunity
PTSD患者外周血單核細胞顯示糖酵解及磷酸戊糖 shunt 路徑活性上升，並伴隨細胞特異性代謝改變（如GLUT1、CPT1a、ACAC），提供免疫代謝失調的初步證據。
Enhancing astrocytic GAT-3 in zona incerta diminishes fear memory generalization through remodeling neural network.
Neurobiology of disease
強化ZI星細胞GAT-3功能可減少條件反射神經元過度放電並正規化神經振動，減少恐懼記憶過度概化，顯示星細胞在PTSD pathogenesis中的調節角色。
PDE2A is involved in negative emotional behaviors via the cAMP-PKA signaling pathway in the SPS&S model.
Journal of affective disorders
在SPS&S PTSD模型中，縮樟素2A經cAMP-PKA通路調節負面情緒行為，其抑制可改善類焦慮與類憂鬱行為，提供新的神經分子靶標。
Eye Movement Desensitisation and Reprocessing (EMDR) for ICU-related psychological distress among adult intensive care survivors: a scoping review.
European journal of psychotraumatology
EMDR在ICU幸存者中顯示減少創傷相關痛苦的初步證據，但對焦慮與憂鬱改善不一致，證據仍屬 preliminarily。
Systematic review and meta-analysis: the effectiveness of cognitive behavioral therapy and eye movement desensitization and reprocessing in children and adolescents.
European journal of psychotraumatology
在兒青年中，CBT與EMDR對PTSD症狀無顯著差異，但CBT組憂鬱症狀較高，提示兩種療法在情緒症狀上可能有不同影響。
Oxytocin preserves excitatory responsiveness of VTA dopaminergic neurons in PTSD model rats.
IBRO neuroscience reports
雖PTSD模型鼠VTA多巴胺神經元基礎活性降低，但其對促織素的興奮性反應被保留，提示促織素系統在PTSD中仍具可塑性，為治療提供生理基礎。
The Case for Peer-Support in Addressing the Mental Health Needs of Ukrainian Refugees in Europe.
Journal of immigrant and minority health
同儕支持對烏克蘭難民在歐洲的心理健康具潛力，尤其對婦女與單親母親，可彌補正規服務不足並增強韌性。
PTSD, optimism, and life satisfaction during early SUD treatment among native Hawaiian and Pacific islander patients.
Journal of substance use and addiction treatment
在夏威夷原住民及太平洋島民SUD早期治療中，較低PTSD症狀與較高樂觀與生活滿意度正相關，支持將強度為基礎的因素納入文化適應性療法。
Qualitative insights on war-related abuses and health consequences: perspectives from Ukrainian veterans and former prisoners of war.
BMJ military health
烏克蘭退伍軍人及前戰俘報告系統性 torture、性暴力等戰爭罪行，並連帶憂鬱、焦慮、PTSD與道德傷害等心理後果，顯示需緊急人道主義回應。
Voices from the field: A mixed methods exploration of posttraumatic stress disorder, complex posttraumatic stress disorder, and moral injury among mass graves workers in Libya.
The American journal of orthopsychiatry
利比亞大墓工作者中超過三分之一符合PTSD標準，近三分之一報告道德傷害（以罪責、背叛為主），顯示其工作所承受之深層心理負擔。
Posttraumatic stress disorder (PTSD) symptoms as a potential explanatory factor in the relation between everyday racial discrimination and binge drinking among ethnoracially minoritized emerging adults.
The American journal of orthopsychiatry
日常種族歧視經過覺醒PTSD症狀部分介入對少數族群新興成年人濫飲酒的影響，提示需針對過覺醒進行早期干預以減少酒害。
Distinguishing moral injury from burnout, secondary traumatic stress, and depression in animal care workers: A condition differentiation analysis.
Psychological trauma : theory, research, practice and policy
動物照護工作者的道德傷害在統計上可與倦怠、二次創傷壓力及憂鬱區分，且現有工具未能捕捉近半數道德困窘個體，提升評估工具需求。