⭐今日精選 TOP Picks
Extinction-restraint intervention eradicates fear memory encoded in BLA engram cells via D2 receptor-mediated dopaminergic modulation from locus coeruleus
Experimental & molecular medicine · Extinction-restraint intervention eradicates fear memory encoded in BLA engram cells via D2 receptor-mediated dopaminergic modulation from locus coeruleus
該研究發現極簡化的暴露-限制干預可透過多巴胺D2受體介導的藍斑核-側坐核迴路擦除恐懼記憶，為防止PTSD復發提供神經機制基礎的新穎療法。
PPTSD相關恐懼復發動物模型
IExtinction-restraint intervention (Ext-Res)
C標準暴露療法或無干預
OBLA engram細胞重新激活之恐懼記憶抑制及DP受體依賴性去激活
PTSD is associated with an increased risk of subsequent development of autoimmune disorders
Brain, behavior, and immunity · New-onset autoimmunity in people living with post-traumatic stress disorder.
大規模隊列研究證實PTSD顯著增加未來自身免疫疾病風險（HR=1.34），提示需將免疫監測納入PTSD長期照護。
P新診斷慢性PTSD且無基礎自身免疫病者（n=316,482）
I無（觀察性暴露於PTSD診斷）
C無PTSD對照組
O5年內32種新發自身免疫疾病之風險增加
National identity as both cure and curse: The effects of three facets of national identification on post-traumatic stress (PTS) symptoms in wartime Ukraine
The British journal of social psychology · National identity as both cure and curse: The effects of three facets of national identification on post-traumatic stress (PTS) symptoms in wartime Ukraine
研究發現國家認同的『身份中心性』惡化PTS症狀，而『內群體連結與情感』則具有保護作用，揭示社會身份在創傷復雜中的雙刃劍角色。
P烏克蘭境內居民（N=1012）及波蘭難民（N=381）
I無（觀察性國家認同維度）
C不同國家認同維度（內群體結束、情感、中心性）
O身份中心性與PTS症狀正相關；內群體結束與情感為保護因子
Screening for Posttraumatic Stress Disorder in Mothers of Premature Infants: An Evidence-Based Approach
The Journal of perinatal & neonatal nursing · Screening for Posttraumatic Stress Disorder in Mothers of Premature Infants: An Evidence-Based Approach.
在NICU中推行結構化篩選流程可發現25%早產兒母親具有高度PTSD可能性，證實系統化篩查的可行性與必要性。
P早產兒（<30週）母親（N=16）
I教育員工使用City Birth Trauma Scale、規範化評估及指定護士冠軍
C無系統篩查
O25%符合高度PTSD可能性，50%報告顯著生活機能受損
Prospective Development of a Whole-Brain Connectivity and Electric Field-Guided Transcranial Magnetic Stimulation Atlas for Posttraumatic Stress Disorder Symptoms
Biological psychiatry global open science · Prospective Development of a Whole-Brain Connectivity and Electric Field-Guided Transcranial Magnetic Stimulation Atlas for Posttraumatic Stress Disorder Symptoms.
透過整合功能連接與電場模型建立全腦TMS標靶圖譜，預測左前額葉連接增加與 bilateral 頂額葉減少皆可減輕PTSD症狀，為個人化神經調節療法鋪路。
P有及無PTSD的退伍軍人（N=350）
I模擬TMS於200個皮質部位之電場影響
C無導引之刺激
O左前額葉連接增加預測症狀減少；bilateral 頂額葉連接減少亦預測症狀減少
Effectiveness of psychological interventions for remote workplace trauma: an evidence review.
Occupational medicine (Oxford, England) · Effectiveness of psychological interventions for remote workplace trauma: an evidence review.
快速檢證顯示常見職場創傷干預（如正念、心理諮詢）效益有限，反而強烈建議避免強制性心理諮詢，支持督導與非正式支援為更有效替代方案。
P暴露於痛苦材料的高風險工作者
I心理健康篩檢、訓練、諮詢/德布里ーフィング、正念/韌性程式
C自然恢復或無干預
O篩檢、常規諮詢、正念無益；諮詢/德布里ーフィ效果混合；督導與非正式支援獲質化支持
Complex PTSD symptom trajectories in trauma-exposed adolescents: a five-year longitudinal study.
European journal of psychotraumatology · Complex PTSD symptom trajectories in trauma-exposed adolescents: a five-year longitudinal study.
五年縱貫研究顯示，雖然C-PTSD診斷穩定性低，但符合末波C-PTSD者其症狀隨時間惡化，凸顧早期識別與持續追蹤的重要性。
P創傷暴露青少年（N=156，五年三波）
I無（觀察性症狀軌跡）
C無創傷 disorder 組
O末波C-PTSD組所有症狀群隨時間上升；情感調節失調與關係受擾症狀具有穩定性
Associations Among Mental Health Symptom Severity, Loneliness, and Suicidal Thoughts and Behaviors in the Army National Guard.
Military medicine · Associations Among Mental Health Symptom Severity, Loneliness, and Suicidal Thoughts and Behaviors in the Army National Guard.
在陸軍國民警衛隊中，抑鬱症狀與孤獨感是自殺行為的最強預測因子（非PTSD），其交互作用進一步放大風險，揭示需超越聚焦PTSD的綜合心理健康策略。
P陸軍國民警衛隊成員（N=1,991）
I無（觀察性關聯）
C無
O抑鬱（β=.358）> 孤獨（β=.224）> 酒精濫用（β=.075）預測STB；孤獨與抑鬱/PTSD/酒精交互顯著
📚其他值得關注的文獻
Audiologic Characteristics of Military Service Members and Veterans With and Without Tinnitus and Comorbid Posttraumatic Stress Disorder.
American journal of audiology
PTSD與耳鳴共病時，功能性受損、惱怒感增加及接受度降低，顯示PTSD加重耳鳴主觀痛苦而非純粹聽損。
Practice Elements in Targeted and Universal Child Mass Trauma Interventions.
Trauma, violence & abuse
兒童大規模創傷介入中，心理教育、情緒調節與放鬆為最常見元素；目標群更常接受敘事與照護者心理教育，普遍群則偏重社會技能與正念。
Childhood maltreatment and disrupted parenting in mothers exposed to intimate partner violence: Mediation via mothers' posttraumatic stress symptoms?
Infant mental health journal
競爭暴露母親的童年虐待與創傷後應激症狀呈正相關，但未發現該症狀在 disrupted parenting 中的顯著中介效應。
When Chronic Risk Meets Acute Strain: Sudden Cardiac Death and Cardiovascular Vulnerability in Firefighters.
Clinical Medicine Insights. Cardiology
消防員之心血管猝死源於基礎動脈粥樣硬化與緊急作業時的交感神經激增互作，非獨特職業病，強調風險因子管理與職業壓力調適的重要性。
Corrigendum to "Pathophysiological pathways of post-traumatic stress disorder in relation to traumatic brain injury: An observational cross-sectional study".
SAGE open medicine
僅為先前論文的勘誤，無新科學內容。
Compassion-Fatigue Latent Profile Analysis A Cross-Sectional Study of Psychiatric Nurses' Typologies and Their Predictors.
Journal of psychiatric and mental health nursing
精神護理師之慈悲疲憂可分為三型：輕度創傷應激型（18.5%）、中度低倦怠型（64.0%）、重度疲憂型（17.5%），其中年齡與工作年資為重要預測因子。
U.S. Policy as a Pathogen: A Systematic Review of Somatic and Psychological Distress Among Immigrants.
Journal of immigrant and minority health
美國移民與執法政策功能如結構性病原，透過拘禁、家庭分離與重置壓力提升PTSD、憂鬱等風險，強調政策層面干預的必要性。
Acceptance of a general practitioner-led narrative exposure intervention on post-traumatic stress symptoms after intensive care: a qualitative interview study with providers.
BMJ open
全科醫師導敘事暴露療法於ICU後PTSD患者中的接受度取決於訓練、督導與諮詢時間排配，但被視為可行之選擇。
National trends in mental health outcomes among U.S. combat veterans by war era.
Journal of psychiatric research
伊拉克/阿富汗戰爭老兵具有最高終身PTSD盛行率（21.9%），且近年各時代老兵廣泛焦慮與自殺念頭顯著上升，提示時代別需求與服務缺口。
"Slow" Trauma to Families with the Demise of Family-Centered Care and Trauma-Informed Care.
The Journal of clinical ethics
區分「快速創傷」與「慢速創傷」後者源於照護決策中的持續道德傷害，隨家庭中心照護式樣衰落而增加，提示倫理諮詢需關注累積性壓力與臨床斷點。
Sleep Disturbance in Adults with Type 2 Diabetes: Psychosocial Factors Across Anxiety Symptom Groups.
Diabetes, metabolic syndrome and obesity : targets and therapy
2型糖尿病伴焦慮者失眠盛行率達82.2%，顯著高於無焦慮組（42.3%），提示需分層評估睡眠與創傷後壓力等社會心理因子。
Collective trauma in the wake of historical environmental contamination.
Journal of health psychology
歷史性環境污染經由健康憂慮、環境正義觀點與世界假設破裂介介導致集體創傷，支持社區參與式研究與介入。
Does time matter? The temporal relationship between peritraumatic reactions and post-traumatic stress disorder: parallel-process latent growth curve model.
BJPsych open
地震後初始創傷性解離與痛苦預測較嚴重的早期PTSD，但不影響長期症狀軌跡，支持超越早期評估的多階段篩檢模式。
Descriptive analysis of PTSD, posttraumatic growth, and psychological resilience in adolescents 1 year after an earthquake: Identifying influencing factors.
Journal of health psychology
土耳其青少年在地震後一年顯示PTSD與創後成長呈正相關（r=.21），女生及喪失親友者症狀更重，凸顯創傷後適應的複雜動態。
Long-term Cardiovascular and Psychological Outcomes of Multisystem Inflammatory Syndrome in Children: A Prospective Observational Study (COPE MIS-C study).
The Pediatric infectious disease journal
MIS-C兒童長期隨訪顯示心臟功能完全恢復、無焦慮或PTSD症狀，提示其預後良好僅少數持續輕微冠狀動脈異常。
Attachment anxiety, attachment avoidance, gestational stage and post-loss period as predictors of PTSD symptom severity following miscarriage.
Psychology and psychotherapy
流產後PTSD症狀 severity 由依附焦慮、迴避、最近期內發生及較晚孕週獨立預測，支持早期篩檢與依附導向介入。
Childhood emotional maltreatment and trauma-related outcomes: a systematic review and multilevel meta-analysis.
European journal of psychotraumatology
童年情感虐待與忽視均顯著增加PTSD/CPTSD風險（r=.27），情虐影響略大，提示需納入創傷知照評估核心組成。
Gender differences in trauma type but not PTSD symptoms among Latine Americans.
Journal of behavioral medicine
拉美裔男女在PTSD症狀上無顯著差異，但創傷類型性別分化明顯：女性更多性暴力，男性更多健康與喪失相關創傷，後者經由創傷類型影響症狀嚴重度。
Estimating the Causal Effect of Alcohol Consumption on Military-Relevant Mental Health Conditions: A Mendelian Randomization Study Using the All of Us Research Program.
Military medicine
孟德爾隨機化分析未發現酒精攝取對PTSD、憂鬱或焦慮的致因效應，雖觀察顯著相關，但酒精使用 Disorder 的致因性得以確認。
Parental perspectives on delirium in paediatric cardiac patients: a North American survey.
Cardiology in the young
目睹兒童心臟病 delirium 的父母常感極度困擾，39% 檢測出可能PTSD，顯示需加強親友支持與創傷知照。
Indiscriminate trauma preventions may discriminate: A randomised controlled trial of group psychological first aid.
Behaviour research and therapy
團體心理急救（PFA）在高初始痛苦者可能惡化後續創傷症狀，挑戰其預防性定位，支持個人化、步驟式介入而非單一普遍應用。
Turkish UCLA PTSD-RI-5: Validation and the Role of Symptom Severity in Functional Impairment.
International journal of methods in psychiatric research
土耳其版UCLA PTSD-RI-5展現良好效度與信度，總分及特定症狀群（C、D、E）可預測發育、家庭、同儕與學校功能受損。
Suicidal thoughts and behaviours in Cape Town: A cross-sectional study of prevalence and social, contextual, and clinical correlates.
SSM. Mental health
開普敦貧困社區自殺 ideation 盛行率達14.0%，受精神疾病（尤其PTSD OR=1.32）、社區暴力與 perceived stress 強烈驅動，凸顯社會結構在風險中的核心角色。
Research to real-world impact: evidence-based knowledge mobilization to improve support for UK women veterans who have experienced military sexual trauma.
European journal of psychotraumatology
英國女性退伍軍人軍事性創傷知識轉化計畫成功提升認知處理療法（CPT）執行自我效能（r=0.915），顯示標準化培訓在縮小服務落差中的關鍵角色。
Differential effects of stress by sex and stress model: the source matters.
Stress (Amsterdam, Netherlands)
壓力效應依賴於壓力來源類型與性別，無法簡單概覽，提示需針對具體應激源與性別差異設計行為與神經內分泌研究。
Prospective Development of a Whole-Brain Connectivity and Electric Field-Guided Transcranial Magnetic Stimulation Atlas for Posttraumatic Stress Disorder Symptoms.
Biological psychiatry global open science
透過功能連接與電場模擬建構全腦TMS標靶圖譜，預測左前額葉連接增加及bilateral頂枕葉連接減少皆可降低PTSD症狀，為個人化神經調節提供依據。
Group-Based Interventions for Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis of the Role of Trauma Type.
Campbell systematic reviews
40項研究顯示團體創傷焦點療法整體優於對照，且創傷類型（如戰鬥）與群體契合度（如性別共享）為關鍵調節變項，支持設計文化敏感且類型特定之團體介入。
The critical role of microglia in the stress response.
Neuroscience and biobehavioral reviews
微膠細胞在應激反應中扮演核心免疫調節角色，其異常激活與多種應激相關疾病（包括PTSD、憂鬱、老年癡呆） pathogenesis 相關，提醒神經免疫為治療標的之潛力。
Effect of the polytrauma clinical triad on suicide risk among U.S. veterans and active-duty soldiers.
Psychiatry research
PTSD+TBI+慢性疼痛三聯症顯著增加美軍退伍軍人與現役兵自殺風險（OR up to 4.4），尤其由PTSD驅動，提醒複合創傷臨床需優先自殺風險評估。
Evaluating the association between potentially morally injurious events (PMIEs) and types of psychological distress. A systematic review.
European journal of psychotraumatology
背叛類型道德傷害事件與PTSD、憂鬱、焦慮最一致相關；委託型則與自殺行為較關聯；支持未來研究應區分PMIE子類型以精準了解其心理影響。
Exploring the impact of event-related and personal vulnerability characteristics on mental health after pandemic-related trauma exposure.
European journal of psychotraumatology
疫情創傷後，個人脆弱因子（如缺乏社交支持）比事件本身更預測持續心理症狀，支持危機中維持社會連結與情感支援的政策。
Breakthrough Pain During Cesarean Delivery.
Anesthesiology clinics
剖腹產過程中之突破性疼痛與產後創傷後應激障礙相關，提示麻醉師需關注產程心理安全而非僅聚焦鎮痛。
The Anesthesiologist's Role in Trauma-Informed Care: An Update.
Anesthesiology clinics
麻醉師應擴展角色以實踐創傷知照原則：從認識創傷普遍性到抗再創傷，尤其在產科中預防可避免之創傷與減輕心理傷害具有關鍵影響。
Mechanisms of change in mobile app-delivered acceptance and commitment therapy for posttraumatic stress disorder in China: a secondary analysis of a randomized controlled trial.
European journal of psychotraumatology
手機APP導引ACT療法透過接受、自我為context、認知融脫與承諾行為完全中介PTSD改善，顯示心理彈性核心機制之臨床可行性。
Client and therapist experiences with the Processing of Positive Memories Technique (PPMT) in a randomized controlled trial: insights for protocol refinement.
European journal of psychotraumatology
積極記憶處理技術（PPMT）在PTSD患者中可行性與接受度良好，客戶報告情緒與認知益處，療師視其為創傷焦點療法之有價值輔助，惟需強化記憶檢索支援與彈性會期設計。
Reductions in cigarette use in a pilot intervention for opioid use disorder and PTSD.
European journal of psychotraumatology
結合療治阿片使用障礙與PTSD的初步介入伴隨每日香菸使用顯著減少（-0.93支），雖樣本小，提示統合治療可能同時改善共病物質使用。
Post-traumatic stress disorder and related disorders in elite athletes: a narrative review.
British journal of sports medicine
精運動員因暴露於個人與集體層面的創傷與壓力，較一般人群更易創傷後應激障礙等疾病，但因複雜症狀與應對策略常被掩飾，提倡創傷知照文化與團隊式介入以提升早期偵測。