⭐今日精選 TOP Picks
Dronabinol for nightmares in post-traumatic stress disorder: a randomized controlled trial.
Nature medicine · Dronabinol for nightmares in post-traumatic stress disorder: a randomized controlled trial.
Dronabinol顯著減少PTSD相關夢魘頻率與強度，提供新藥物治療選擇，但需關注長期安全性與不良反應。
P有PTSD且反覆做夢的成人（n=171）
IDronabinol（2.5-15mg）
C安慰劑
OCAPS-IV B2項目（夢魘頻率與強度）改善
Group-Based Interventions for Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis of the Role of Trauma Type.
Campbell systematic reviews · Group-Based Interventions for Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis of the Role of Trauma Type.
團體干預總體優於對照，但效果受創傷類型調節，人際創傷獲益最大，支持針對性團體治療設計。
PPTSD患者（橫跨11國40項研究）
I團體為基礎的治療（CBT、CPT等）
C個別治療或對照
OPTSD症狀減少
Childhood emotional maltreatment and trauma-related outcomes: a systematic review and multilevel meta-analysis.
European journal of psychotraumatology · Childhood emotional maltreatment and trauma-related outcomes: a systematic review and multilevel meta-analysis.
童年情感虐待與PTSD/CPTSD顯著正相關（r=.27），情感虐待影響略大於情感忽視，提醒早期篩檢與干預的重要性。
P323,776名參與者（橫跨57項研究）
I童年情感虐待（CEM）
C無CEM
OPTSD及複雜性PTSD症狀
The occurrence and potential role of mystical experiences in MDMA-assisted therapy for PTSD: A secondary analysis.
Journal of psychopharmacology (Oxford, England) · The occurrence and potential role of mystical experiences in MDMA-assisted therapy for PTSD: A secondary analysis.
MDMA輔助治療中，神秘體驗的「積極情緒」面向顯著 mediate PTSD症狀減少，而非整體神秘體驗強度，優化治療機制理解。
P慢性PTSD患者（n=53）
IMDMA輔助治療
C主動安慰劑
OPTSD症狀（CAPS-IV）減少經由MEQ30積極情緒子量表中介
Trauma-informed weight lifting as an adjunctive intervention for posttraumatic stress among youth in residential treatment.
Psychological trauma : theory, research, practice and policy · Trauma-informed weight lifting as an adjunctive intervention for posttraumatic stress among youth in residential treatment.
創傷知覺舉重可提升青少年的身體感知並短期降低PTSD症狀，但效果無法維持，提示需結合其他干預以鞏固獲益。
P住宿治療中的青少年與年輕成人（N=12）
I創傷知覺舉重（TIWL），8週
C常規治療
OPTSD症狀、抑鬱、壓力減少及身體感知提升
Freezing as a measure of fear: sex differences and implications for preclinical research.
Frontiers in neuroendocrinology · Freezing as a measure of fear: sex differences and implications for preclinical research.
啞動凍結行為可能無法充分捕捉恐懼處理的性別差異，僅在雄性啮齒動物中與電擊強度相關，質疑其作為PTSD預臨床模型的效度。
P野生型啮齒動物恐懼條件反射研究
I恐懼條件反射與消退
C雄性 vs 雌性啮齒動物
O啞動凍結水平及其與電擊強度的關聯
National identity as both cure and curse: The effects of three facets of national identification on post-traumatic stress (PTS) symptoms in wartime Ukraine.
The British journal of social psychology · National identity as both cure and curse: The effects of three facets of national identification on post-traumatic stress (PTS) symptoms in wartime Ukraine.
國家認同的「身份中心性」增加PTS症狀，而「羣體絆繫與情感」則具保護作用，揭示社會身份的雙刃劑效應。
P烏克蘭人（N1=1012）及波蘭烏克蘭難民（N2=381）
I國家認同的三個面向（羣體絆繫、羣體情感、身份中心性）
C低 vs 高國家認同面向
O創傷後壓力症狀（PTS）
Extinction-recruited prefrontal-hypothalamic pathway encodes positive affect to sustain fear extinction in post-traumatic stress mouse model.
The Journal of clinical investigation · Extinction-recruited prefrontal-hypothalamic pathway encodes positive affect to sustain fear extinction in post-traumatic stress mouse model.
前預frontal假下通路編碼消退期間的積極情緒，以維持恐懼消退長期效應，提供神經機制解釋為何積極體驗利於治療。
PPTSD小鼠模型
I恐懼消退程序
C消退誘導的mPFC投射至SuMGlu vs ZISST神經元
O恐懼消退長期持續性及對自發性恢復的抵抗力
📚其他值得關注的文獻
Prelimbic cortex-associated stress sensitisation and region-specific mitochondrial adaptations across preclinical approaches relevant to PTSD and depression.
Neurobiology of stress
前預frontal亞區（prelimbic）在PTSD樣表型中表現出特殊的線粒體適應，提示其為應激敏感化的關鍵神經節點。
Attachment anxiety, attachment avoidance, gestational stage and post-loss period as predictors of PTSD symptom severity following miscarriage.
Psychology and psychotherapy
依戀焦慮與迴避、喪失後期間及懷孕週數獨立預測流產後PTSD症狀嚴重度，支持依戀知晤的早期干預。
Gender differences in trauma type but not PTSD symptoms among Latine Americans.
Journal of behavioral medicine
拉美裔男女在創傷類型上有顯著差異（女性較多性侵害，男性較多健康與喪失創傷），但PTSD症狀無性別差異，提示創傷類型為症狀的主要驅動因素。
Estimating the Causal Effect of Alcohol Consumption on Military-Relevant Mental Health Conditions: A Mendelian Randomization Study Using the All of Us Research Program.
Military medicine
雖觀察顯示酒精與PTSD強關聯，但孟德爾隨機化未發現酒精對PTSD的因果效應，提醒需謹慎解讀關聯性。
From predictive algorithms to generative intelligence: a decadal bibliometric mapping of global research frontiers in AI-driven mental health (2016-2025).
Australian journal of psychology
AI在心理健康領域從探索性算法發展轉向以患者為中心的臨床應用，但需關注偏見、隱私與倫理問題。
Parental perspectives on delirium in paediatric cardiac patients: a North American survey.
Cardiology in the young
目睹兒童心臟病患者 delirium 的父母中有比例符合PTSD標準，提醒需關注照護者創傷與提供支援。
Indiscriminate trauma preventions may discriminate: A randomised controlled trial of group psychological first aid.
Behaviour research and therapy
團體心理急救（PFA）在高初始困擾個體中可能干擾自然復原並增加後續創傷症狀，挑戰其普遍適用性。
Program evaluation of a peer-led posttraumatic stress disorder psychoeducation group for veterans considering treatment services in a Veterans Affairs specialty clinic.
Psychological services
同伴領導的PTSD psycheducation組促進半數以上退伍軍人啟動治療，並改善症狀與復原策略，顯示同伴支持的實用價值。
Childhood betrayal trauma, psychopathic traits, and PTSD symptomology: The role of ambiguity tolerance, distress tolerance, and impulse control difficulties.
Psychological trauma : theory, research, practice and policy
童年背叛創傷透過容忍困擾與衝動控制困難間接影響PTSD與反社會人格特質，揭示跨診斷機制。
Burnout, compassion fatigue, secondary traumatic stress, and affecting factors among midwives in Türkiye.
Psychological trauma : theory, research, practice and policy
土耳其助產士中超時工作、創傷性分娩與職業不滿顯著預期倦怠與二次創傷壓力，提示系統性介入的必要性。
Caregiver burden, anxiety, and quality-of-life among informal caregivers of patient with head and neck cancer: a systematic review.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
頭頸癌照護者常見焦慮、憂鬱與PTSD，照顧負擔與生活品質呈負相關，強調需針對高風險群體提供技能與社會支援。
Parental Resolution of Infant Congenital Heart Disease and Bonding in the Pediatric Cardiac Intensive Care.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
父母對先天性心臟病的解度與健康依附正相關，而憂鬱與PTSD症狀預測較差解度與依附，強調需整合心理支援於ICU照護。
Turkish UCLA PTSD-RI-5: Validation and the Role of Symptom Severity in Functional Impairment.
International journal of methods in psychiatric research
土耳其版UCLA PTSD-RI-5顯示良好效度與信度，得分預測功能受損（如學校、家庭），支持其作為青少年PTSD評估工具。
Suicidal thoughts and behaviours in Cape Town: A cross-sectional study of prevalence and social, contextual, and clinical correlates.
SSM. Mental health
開普敦貧困社區自殺思想與行為高發，並強烈關聯PTSD、暴露暴力與感知壓力，凸顯社會結構在自殺風險中的作用。
Multipathway modulation of neuroinflammation and oxidative stress by hesperidin in a rat single prolonged stress model of post-traumatic stress disorder.
Animal models and experimental medicine
橙皮素在SPS模型中同時抑制神經發炎與氧化應力，並上調BDNF，顯示多靶點神經保護潛力。
Trauma therapy: risks, side effects, and the forensic implications of treatment history.
Memory (Hove, England)
創傷治療可能因既有錯誤記憶或信念而導致偽記憶植入，尤其在司法情境中需警惕，建議治療前進行詳細病史詢問。
Mental Health Treatment Utilization Among Patients Receiving Collaborative Care for Co-occurring Disorders.
Psychiatric services (Washington, D.C.)
在合作照護模式下，阿片類共用、教育程度較低與男性較少接受諮商，而較嚴重憂鬱/PTSD則增加諮商可能性，顯示治療獲取的不平等。
Latent Profiles of Big Five Personality Traits in First Responders: Associations with PTSD, Psychological Distress, Social Support, Attachment, and Emotion Regulation Strategies.
Journal of trauma & dissociation : the official journal of the International Society for the Study of Dissociation (ISSD)
第一線人員中高神經質與低盡責性等人格特質檔案與較高PTSD相關，支持人格知晤的預防與個人化干預。
Ten Years of Outcomes in a National Mental Health Network for Veterans, Service Members, and Military Families.
The journal of behavioral health services & research
CVN網路十年來持續改善退伍軍人等群體的心理症狀（如PTSD降緩16.5-18.4分），證明社會特許模式可大規模提供有效心理照護。
Differential effects of stress by sex and stress model: the source matters.
Stress (Amsterdam, Netherlands)
壓力類型與性別共同影響行為與神經內分泌反應，提醒無法簡單概括壓力效應，需考慮壓力來源與個體差異。
Integrated mental health treatment and employment services for refugees with PTSD: randomised controlled trial.
BJPsych open
對失業難民PTSD的整合照護（心理+就業服務）未顯著改善主要結論，但降低提前退出並提升治療滿意度，顯示可行性與潛在價值。
[Sense of coherence - revised as a metacognitive ability: Evidence from a Swiss study of older trauma survivors].
Psychotherapie, Psychosomatik, medizinische Psychologie
修訂版認譶感（SOC-R）在老年創傷倖存者中顯示中度穩定性，並由成就動機預測應對與反思能力，提示其具備 metacognitive 能力特質。
Extinction-recruited prefrontal-hypothalamic pathway encodes positive affect to sustain fear extinction in post-traumatic stress mouse model.
The Journal of clinical investigation
前預frontal假下通路編碼消退期間的積極情緒，以維持恐懼消退長期效應，提供神經機制解釋為何積極體驗利於治療。
Childhood maltreatment impacts the activity of the neural empathy but not theory of mind network: findings from a transdiagnostic sample.
European archives of psychiatry and clinical neuroscience
童年虐待與共情神經活動（尤其是 dorsomedial PFC）負相關，但不影響心智理論網路，提示共情受損為跨診斷機制。
Change in Mental Health and Resilience in Childhood Cancer Survivors After Attending a Person-Centred State-of-the-Art Late Effects Clinic-on Behalf of the PanCareFollowUp Consortium.
Pediatric blood & cancer
兒童癌症倖存者參加以個人為中心的隨診後，憂鬱、焦慮與PTSD症狀顯著改善，尤其對失業、單身或身體狀況不佳者效果較佳。
Interdependent post-traumatic stress symptoms and health-related quality of life in ICU survivor-caregiver dyads: A prospective exploratory pilot study.
Medicina intensiva
ICU出院後，患者與照護者PTSD症狀高度一致（82%同意），並與生活品質惡化相關，提示需以雙人為單位進行創傷評估與支援。
Internal and external protective factors associated with the secondary traumatic stress component of compassion fatigue, in feral cat caregivers.
PloS one
照顧流浪貓者中，照顧大量貓群與失業增加二次創傷壓力，而年長、家庭支持與寧懿感則具保護作用，提醒意義感可能反而增加易感性。
Perinatal Mood and Anxiety in Women Undergoing Open Maternal Fetal Surgery for Myelomeningocele Closure.
Fetal diagnosis and therapy
接受開放式母胎外科手術的孕婦產前憂鬱與焦慮率高，產後顯著下降，強調需常規篩檢與社會支持。
Nicotine in Neurodegenerative and Neuropsychiatric Disorders: Mechanisms and Clinical Evidence.
Neurochemical research
尼古丁經調節乙�鹼受體影響多種神經遞質系統，在PTSD等神經精神疾病中具調節潛力，但成癮性與受體脫敏是主要限制。
Optimal screening selection rates for post-traumatic stress disorder and the impact of social stigma.
Health care management science
PTSD篩檢閾值需平衡成本與社會污名，以避免因污名抑制早期發現而惡化長期結果，提倡動態調整策略。
Trauma-informed weight lifting as an adjunctive intervention for posttraumatic stress among youth in residential treatment.
Psychological trauma : theory, research, practice and policy
創傷知覺舉重可提升青少年的身體感知並短期降低PTSD症狀，但效果無法維持，提示需結合其他干預以鞏固獲益。
Provider well-being in the intensive virtual evidence-based psychotherapy team: A program description with preliminary evaluation data in the Veterans Health Administration.
Psychological services
虛擬強化心理治療團隊初步顯示提升員工 perceived support 與減少 burnout、二次創傷壓力與道德困擾，支持結構化設計以促進提供者福祉。
Where is the sweet spot for psychedelic-enhanced fear extinction? An integrative quantitative synthesis of dose-effect patterns in rodent models.
Journal of psychopharmacology (Oxford, England)
經典致幻劑（如psilocybin、ketamine）對恐懼消退的劑量效應呈線性關係，低劑量常較有效，但給藥時機可能影響持續性。
A Scoping Review of Person-Centered Mental Health Care for Migrants and Refugees in Humanitarian Settings.
The International journal of social psychiatry
難民與移民心理健康需求高但服務利用低，主要障礙為語言、政策與文化能力，提倡將人-centred 原則納入國家政策與初級照護。
Latent Profiles of Traumatic Psychological Responses and Their Association With Postpartum Depression Among High-Risk Pregnant Women: A Latent Profile Analysis.
Western journal of nursing research
高風險孕婦中，創傷痛苦類型與產後憂鬱最高相關，而成長導向類型則為保護因子，支持以類型為基礎的早期幹預。
Prospective Development of a Whole-Brain Connectivity and Electric Field-Guided Transcranial Magnetic Stimulation Atlas for Posttraumatic Stress Disorder Symptoms.
Biological psychiatry global open science
基於連結功能與電場模型構建的全腦TMS靶標圖譜，預測左前prefrontal刺激降低症狀，而額葉後部刺激亦可減少症狀，為個別化TMS提供依據。
Group-Based Interventions for Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis of the Role of Trauma Type.
Campbell systematic reviews
團體干預總體優於對照，但效果受創傷類型調節，人際創傷獲益最大，支持針對性團體治療設計。
Evaluating the association between potentially morally injurious events (PMIEs) and types of psychological distress. A systematic review.
European journal of psychotraumatology
背叛類型潛在道德傷害事件與PTSD、憂鬱與焦慮最一致相關，支持將PMIE細分型別納入評估與研究。
Exploring the impact of event-related and personal vulnerability characteristics on mental health after pandemic-related trauma exposure.
European journal of psychotraumatology
個人脆弱因素（如缺乏社會支持）比事件本身更能預測疫情創傷後的心理健康軌跡，提醒後疫情時代需加強社會連結。