⭐今日精選 TOP Picks
Establishing diagnostic thresholds for adult ADHD screening in taxi drivers: validation of the CAARS-S via Item Response Theory and Machine Learning.
Journal of injury & violence research · Establishing diagnostic thresholds for adult ADHD screening in taxi drivers: validation of the CAARS-S via Item Response Theory and Machine Learning.
在德全球首次為特定高風險職業（計程車司機）建立經驗驗證的CAARS-S割離點，機器學習與IRT結合提升職場篩檢準確度，敏感度達88%、特異度86.7%，具高度實用價值。
P298名伊朗男性計程車司機（平均年齡36.8歲）
I波斯語版CAARS-S:SV自評量表
C無（診斷效度研究，以臨床診斷為參照標準）
OROC與Random Forest模型識別總分裁剪點，敏感度88%，特異度86.7%；IRT模型因多維度假設違反而在總分上表現不佳
💡 提供首個經驗驗證的職業場域ADHD篩檢裁剪點，對降低專業司機事故風險具直接預防意義。
Emotion regulation difficulties in adults with ADHD and associations with insomnia symptoms.
Journal of affective disorders · Emotion regulation difficulties in adults with ADHD and associations with insomnia symptoms.
情緒調節困難（特別是策略受限）與失眠症狀顯著正相關，且此關聯在30歲以下 emerging adults 中較強，提醒臨床需同步評估情緒與睡眠。
P1414名自報成人ADHD患者（81%女性，平均年齡40歲）
I情緒調節量表與失眠症狀自評
C內部比較（情緒調節能力高低組）
O情緒調節困難預測較多失眠症狀（β顯著），效應量在<30歲組為中等，≥30歲組為小效應
💡 揭示ADHD中情緒與睡眠的雙向關聯，支持將情緒調節訓練納入非藥物療法，尤其對年輕成人。
Effects of a novel individualized digital cognitive training on ADHD characteristics, quality of life, and cognitive functioning in adults with ADHD: A randomized controlled trial.
Journal of psychiatric research · Effects of a novel individualized digital cognitive training on ADHD characteristics, quality of life, and cognitive functioning in adults with ADHD: A randomized controlled trial.
NeuroNation MED數位認知訓練顯著提升心理生活品質與主觀認知感受（如注意、記憶），但未改善客觀神經心理表現，凸顯主觀與客觀 outcome 的脫節。
P77名成人ADHD患者（德國）
I12週個人化數位認知訓練（NeuroNation MED）
C治療常規（TAU）交叉設計對照組
O心理生活品質顯著改善；主觀認知提升（d=0.47–0.94），但客觀執行功能與ADHD核心症狀無顯著變化
💡 雖未改善客觀認知，但提升主觀幸福感與自我效能，適合作為藥物療法的輔助工具，尤適於對自我感受敏感的患者。
Establishing diagnostic thresholds for adult ADHD screening in taxi drivers: validation of the CAARS-S via Item Response Theory and Machine Learning.
Journal of injury & violence research · Establishing diagnostic thresholds for adult ADHD screening in taxi drivers: validation of the CAARS-S via Item Response Theory and Machine Learning.
重複條目，見rank 1。
P298名伊朗男性計程車司機（平均年齡36.8歲）
I波斯語版CAARS-S:SV自評量表
C無（診斷效度研究，以臨床診斷為參照標準）
OROC與Random Forest模型識別總分裁剪點，敏感度88%，特異度86.7%；IRT模型因多維度假設違反而在總分上表現不佳
💡 提供首個經驗驗證的職業場域ADHD篩檢裁剪點，對降低專業司機事故風險具直接預防意義。
Behavioral and Self-Report Measures of Spontaneous Mind Wandering Predict Different Aspects of ADHD in Adults.
Journal of attention disorders · Behavioral and Self-Report Measures of Spontaneous Mind Wandering Predict Different Aspects of ADHD in Adults.
自發性心游離（S-MW）的自我報告與行為表現（Stroop任務中經驗取樣）獨立預報ADHD症狀，提示S-MW涉及注意力與衝動兩種不同機制的干擾。
P未明確樣本數，但為完成ASRS及心游離量表的成人
I自發性心游離（S-MW）量表與行為測量（連續計數Stroop任務+經驗取樣）
C內部預測分析（S-MW分數 vs. ASRS分數）
OS-MW自評分數與在S-MW狀態下的Stroop準確度，獨立預報較高ASRS分數
💡 提供認知過程層面的機制證據，有助開發更精準的評估工具或針對性注意訓練。
📚其他值得關注的文獻
The Impact of Citicoline/Phosphatidylserine Supplementation on Cognitive Performance and Executive Functions in Mental Disorders: A Systematic Review of Controlled Trials.
Human psychopharmacology
膠固醇與磷脂酰塞린在ADHD兒童中對注意與衝動的效益不一致（3/5研究正向），目前證據不足以支持其作為精神疾病的認知增強劑。
Anna vs. Judith: A randomized comparison of AI-delivered psychodynamic and cognitive behavioral therapies for social anxiety disorder.
Internet interventions
AI-PDT與AI-CBT對社交焦慮皆有中等改善效果，但未顯著優於等候名單；合併ADHD預測較差療效，提醒神經多樣性需求。
Mental health disorders and suicide risk among autistic children, adolescents and adults: a population-based study using linked administrative data.
Lancet regional health. Americas
自閉症者ADHD風險是非自閉症者的5.24倍，併發症負擔極重，尤其女性自殺未遂風險顯著升高。
Clinical and genetic association of comorbid provisional PMDD and ADHD in female patients with bipolar disorder.
Journal of affective disorders
雙極性障礙女性中，臨床暫診PMDD與ADHD症狀在臨床與基因層面（ADHD多基因風險評分）存在關聯，提示共同遺傳易感性。
Tool for Converting ADHD Rating Scales Scores Based on Individual Participant Data from 53 Randomized Controlled Trials of ADHD Medications.
Journal of child and adolescent psychopharmacology
開發出基於個人參與者資料的評分尺度轉換工具（如ADHD-RS與CPRS-R:S），使用樣條模型改善跨研究比較，可用於藥物療法研究的數據 harmonization。
Roles of the nuclear receptor corepressor 1 (NCoR1) and the silencing mediator of retinoid and thyroid hormone receptors (SMRT) in the developing brain.
Life sciences
小鼠研究顯示NCoR1與SMRT在腦中具有獨�調控網路，NCoR1缺失導致學習增強但社交缺陷，功能非冗餘，僅間接關聯ADHD相關認知。
Does opioid replacement therapy for infants with prenatal opioid exposure modify the risk of ADHD in childhood? A matched cohort analysis.
Drug and alcohol dependence
出生後阿片類替代療法（ORT）未顯著修飾產前阿片暴露對兒童ADHD風險的影響（風險差異不 significant），提供使用安慰。
Cannabis for tic control: a systematic review and meta-analysis of its efficacy in Tourette syndrome management.
Neuroscience
大麻藥物顯著減輕Tourette症狀粗動與前兒衝動（YGTSS↓13.29，PUTS↓4.09），但證據仍需更大規模安慰劑對照試驗支持。
Prevalence and outcomes of co-occurring psychiatric and endocrine, metabolic, and nutritional disorders: An atlas based on umbrella review of 254,154,533 records.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
ADHD與糖尿病併發時會升高HbA1c（類型1：SMD=0.7；類型2女性：SMD=0.6），提醒代謝監測的重要性。
UPLC-MS/MS method for quantifying non-stimulant ADHD medications in human breast milk and plasma: Application in a lactating patient receiving atomoxetine.
Journal of pharmaceutical and biomedical analysis
建立測定atomshoxetine在母乳與血漿的穩定方法，母乳/血漿比例低（ATX 0.089），相對嬰兒劑量僅0.086%，支持哺乳期安全使用。
Elevated ADHD symptoms linked to depression and anxiety in women with epilepsy.
Epilepsy & behavior : E&B
癲癇女性中43% ASRS-5陽性，ADHD症狀與憂鬱（R²=0.34）和焦慮（R²=0.32）顯著相關，提醒需鑑別症狀來源。
Treatment patterns and comparative clinical outcomes of ADHD medications in adolescents and young adults with comorbid major depressive disorder.
Journal of affective disorders
併發憂鬱時非興奮劑（特別是bupropion）使用增加，但興奮劑在降低自殺與住院風險方面仍優於非興奮劑，bupropion為可替代選項。
Atomoxetine hydrochloride impairs human sperm quality and function via disruption of calcium homeostasis and PKC signaling: A combined network pharmacology and in vitro study.
Reproductive toxicology (Elmsford, N.Y.)
atomshoxetine在體外劑量依賴性降低精子活動力，50μM時透過干擾PKC依賴的鈣通道影響運動能力，但未顯著增加細胞死亡，提醒生殖風險需評估。
Altered pre-stimulus alpha dynamics index sustained attention difficulties in ADHD.
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
ADHD成人在持續注意任務中，前刺激alpha波動態異常：未能維持前瞻性注意準備，且神經狀態與行為反應脫節，提示注意調節網路功能失調。
Is the Structure of ADHD stable across adulthood? Insights from the CAARS 2.
Psychiatry research
CAARS 2的五因子結構（注意/執行功能、多動、衝動、情緒失調、負自我概念）在成人不同年齡階段顯示強度量表不變性，支持其作為穩定結構的使用。
Perceived stress and addiction severity in adults with ADHD: A multi-domain analysis.
Psychiatry research
在ADHD成人中， perceived stress 是各類成癮嚴重程度的主要預測因，而非ADHD症狀本身；網路遊戲嚴重程度可能增加賭博問題風險。
Theory of Mind Assessment in Adults With ADHD: Four Methodological Concerns.
Acta psychiatrica Scandinavica
文章摘要缺失，僅提及理論心智評估在ADHD成人中的四種方法論限制，無法評估實用值。
Cord blood C-reactive protein and ADHD symptoms at age 5: Evidence from two French birth cohorts.
Brain, behavior, and immunity
臍帶血CRP升高（≥75百分位）與5歲兒童邊緣或異常多動-注意症狀顯著相關（aOR≈1.45），提示 perinatal炎症可能是ADHD風險因子。
Shared and disorder-specific prenatal and perinatal risk factors for neurodevelopmental disorders: a nationwide cohort study.
Molecular psychiatry
全國層面研究證實男性、早産、SGA等為ADHD共享風險因子，併發症調整後顯示某些風險（如極早產）對ASD的影響被高估。
Childhood cognitive control as a predictor of long-term clinical and functional outcomes in Tourette syndrome.
Journal of child psychology and psychiatry, and allied disciplines
兒童期抑制、轉換與處理速度較好預測成年後輕度抽搐症與生活品質升高，但受併發ADHD影響需謹慎解讀。